1.4.3.21: primary-amine oxidase
This is an abbreviated version!
For detailed information about primary-amine oxidase, go to the full flat file.
Word Map on EC 1.4.3.21
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1.4.3.21
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endothelial
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diamine
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1.4.3.6
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ssaos
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deamination
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polyamines
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leukocyte
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putrescine
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lymphocyte
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spermine
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methylamine
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lysyl
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vessel
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arthrobacter
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extravasation
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phenylhydrazine
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2,4,5-trihydroxyphenylalanine
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globiformis
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elastin
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cadaverine
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klinman
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biogenic
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aminoguanidine
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half-reaction
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histaminase
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semiquinone
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pargyline
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acrolein
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pyrroloquinoline
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transmigration
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allylamine
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clorgyline
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beta-aminopropionitrile
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aminoacetone
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copper-binding
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self-processing
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quinoproteins
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2-phenylethylamine
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addressins
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deprenyl
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phenelzine
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medicine
- 1.4.3.21
- endothelial
- diamine
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1.4.3.6
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ssaos
-
deamination
- polyamines
- leukocyte
- putrescine
- lymphocyte
- spermine
- methylamine
-
lysyl
- vessel
- arthrobacter
-
extravasation
- phenylhydrazine
-
2,4,5-trihydroxyphenylalanine
- globiformis
- elastin
- cadaverine
-
klinman
-
biogenic
- aminoguanidine
-
half-reaction
- histaminase
- semiquinone
- pargyline
- acrolein
-
pyrroloquinoline
-
transmigration
- allylamine
- clorgyline
- beta-aminopropionitrile
- aminoacetone
-
copper-binding
-
self-processing
-
quinoproteins
- 2-phenylethylamine
-
addressins
- deprenyl
- phenelzine
- medicine
Reaction
Synonyms
AGAO, AMAO2, AMAO3, amine oxidase 1, amine oxidase, copper containing, AO1, AO2, AOC2, AOC3, BAO, benzylamine oxidase, bovine plasma amine oxidase, bovine serum amine oxidase, BPAO, BSAO, CAO, Copper amine oxidase, copper amine oxidase 1, copper amine oxidase 8, copper-containing amine oxidase, copper-containing AO, copper-containing monoamine oxidase, copper-dependent amine oxidase, copper/quinone containing amine oxidase, Cu/TPQ amine oxidase, CuAO, CuAO1, CuAO2, CuAO3, CuAO8, EC 1.4.3.6, ECAO, ELAO, GPAO, grass pea amine oxidase, Hansenula polymorpha amine oxidase, HPAO, hPAO-1, HPAO-2, lentil seedling amine oxidase, LSAO, MAO-N, More, OVAO, PAO, pea seedling amine oxidase, plasma amine oxidase, PrAO, primary amine oxidase, primary-amine:oxygen oxidoreductase, PSAO, quinone- and copper-containing amine oxidase, quinone-containing copper amine oxidase, quinone-dependent amine oxidase, quinoprotein copper-containing amine oxidase, RAO, sainfoin amine oxidase, semicarbazide-sensitive amine oxidase, semicarbazide-sensitive amine oxidase/vascular adhesion protein-1, SSAO, SSAO/VAP-1, TPQ-containing CuAO, tynA, tyramine oxidase, copper-requiring, VAP-1, vascular adhesion protein 1, vascular adhesion protein-1
ECTree
1.4.3.21 primary-amine oxidaseAdvanced search results
results (
results (KM Value
KM Value on EC 1.4.3.21 - primary-amine oxidase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.13
4-fluorobenzylamine
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
2.05
ethanolamine
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.03
octopamine
-
isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.02
vanillylamine
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.0012
2-Phenylethylamine
wild type enzyme, in 100 mM sodium phosphate buffer (pH 7.0), at 25°C
0.0019
2-Phenylethylamine
pH 6.8, 30°C, Co2+-substituted enzyme
0.0025
2-Phenylethylamine
pH 6.8, 30°C, native copper protein
0.0038
2-Phenylethylamine
pH 6.8, 30°C, Ni2+-substituted enzyme
0.0055
2-Phenylethylamine
isoform AMAO3, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C
0.012
2-Phenylethylamine
isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C
0.077
2-Phenylethylamine
recombinant enzyme expressed in CHO cells
0.11
amylamine
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.16
amylamine
-
isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.0051
benzylamine
-
enzyme from cultured aortic smooth muscle cells, Km decreases with increasing pH
0.013
benzylamine
mutant enzyme L469G, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.018
benzylamine
mutant enzyme M211V/Y394N/L469G, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.025
benzylamine
mutant enzyme M211V, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.04
benzylamine
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.084
benzylamine
mutant enzyme T212A, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.184
benzylamine
wild type enzyme, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.215
benzylamine
mutant enzyme Y394N, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.32
Butylamine
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.32
Butylamine
-
isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
12.7
cadaverine
isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C
0.1
dopamine
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isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.86
ethylamine
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isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.28
histamine
-
isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.41
histamine
isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C
0.88
histamine
isoform AMAO3, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C
0.18
methylamine
-
isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.236
methylamine
mutant enzyme L469G, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.28
methylamine
mutant enzyme M211V, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.331
methylamine
wild type enzyme, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.502
methylamine
mutant enzyme T212A, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
1.26
methylamine
mutant enzyme Y394N, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
2.043
methylamine
mutant enzyme M211V/Y394N/L469G, in Krebs Ringer phosphate glucose buffer, pH 7.4, at 37°C
0.021
O2
-
copper-reconstituted wild type enzyme, with putrescine as cosubstrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
0.026
O2
-
wild type enzyme, with putrescine as cosubstrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
1
O2
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cobalt-substituted wild type enzyme, with putrescine as cosubstrate, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
0.02
Phenylethylamine
-
isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.49
Propylamine
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isoform AO1, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
0.29
putrescine
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copper-reconstituted wild type enzyme, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
0.57
putrescine
-
wild type enzyme, in 100 mM potassium phosphate buffer, pH 7.2, 37°C
7.04
spermidine
isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C
0.02
tyramine
isoform AMAO3, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C
0.03
tyramine
isoform AMAO2, in 100 mM potassium phosphate buffer (pH 7.0), at 37°C
0.05
tyramine
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isoform AO2, in 200 mM potassium phosphate buffer pH 7.6, at 30°C
additional information
additional information
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the Km-value for O2 of the cobalt-substituted enzyme form is approximately 70fold higher than that of the copper-containing wild-type enzyme
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additional information
additional information
comparison of steady-state kinetics of enzyme expressed in CHO and HEK-293 EBNA cells, overview
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additional information
additional information
comparison of steady-state kinetics of enzyme expressed in CHO and HEK-293 EBNA cells, overview
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additional information
additional information
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kinetic analysis at different ionic strength and pH, overview
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