1.4.3.22: diamine oxidase
This is an abbreviated version!
For detailed information about diamine oxidase, go to the full flat file.
Word Map on EC 1.4.3.22
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1.4.3.22
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polyamine
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oxidases
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monoamine
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mucosal
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copper
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spermidine
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deamination
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1.4.3.6
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aminoguanidine
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benzylamine
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endotoxin
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ornithine
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semicarbazide-sensitive
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occludin
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d-lactate
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copper-containing
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cadaverine
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bowel
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biogenic
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semicarbazide
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villus
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ileum
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d-lactic
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jejunal
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lysyl
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tyramine
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zonula
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piglets
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pao
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claudin-1
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methylamine
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n-methyltransferase
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pargyline
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agmatine
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tryptamine
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renalase
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hansenula
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occludens-1
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postheparin
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phenylhydrazine
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lentil
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deprenyl
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beta-aminopropionitrile
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oxidase-like
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clorgyline
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beta-phenylethylamine
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phenylethylamine
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quinoproteins
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samdc
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globiformis
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diagnostics
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analysis
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biotechnology
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medicine
- 1.4.3.22
- polyamine
- oxidases
-
monoamine
- mucosal
- copper
- spermidine
-
deamination
-
1.4.3.6
- aminoguanidine
- benzylamine
- endotoxin
- ornithine
-
semicarbazide-sensitive
- occludin
- d-lactate
-
copper-containing
- cadaverine
- bowel
-
biogenic
- semicarbazide
- villus
- ileum
-
d-lactic
- jejunal
-
lysyl
- tyramine
-
zonula
-
piglets
- pao
-
claudin-1
- methylamine
- n-methyltransferase
- pargyline
- agmatine
- tryptamine
- renalase
- hansenula
-
occludens-1
-
postheparin
- phenylhydrazine
- lentil
- deprenyl
- beta-aminopropionitrile
-
oxidase-like
- clorgyline
- beta-phenylethylamine
- phenylethylamine
-
quinoproteins
- samdc
- globiformis
- diagnostics
- analysis
- biotechnology
- medicine
Reaction
Synonyms
ABP1, AGAO, Amiloride-binding protein, Amine oxidase, BSAO, Copper amine oxidase, DAO, DAO-1, Diamine oxidase, EC 1.4.3.6, ELAO, GPAO, hDAO, histaminase, histamine dehydrogenase, histamine oxidase, LCAO, LSAO, methylputrescine oxidase, More, MPO, N-methylputrescine oxidase, pea seedling amine oxidase, PKAO, PPLO, PSAO, pWGH15, rhDAO, vDAO
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Application
Application on EC 1.4.3.22 - diamine oxidase
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analysis
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the enzyme can be used as biocatalytic component of an electrochemical biosensor for the determination of biogenic amines index in wine and beer samples
biotechnology
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supramolecular tandem assays exploit the dynamic binding of a fluorescent dye with a macrocyclic host in competition with the binding of the substrate and product. Two examples of enzymatic reactions were investigated: the hydrolysis of arginine to ornithine catalyzed by arginase and the oxidation of cadaverine to 5-aminopentanal by diamine oxidase, in which the substrates have a higher affinity to the macrocycle than the products (substrate-selective assays). The depletion of the substrate allows the fluorescent dye to enter the macrocycle in the course of the enzymatic reaction, which leads to the desired fluorescence response. For arginase, p-sulfonatocalix[4]arene is used as the macrocycle, and for diamine oxidase, cucurbit[7]uril (CB7) is used. An additional reporter pair, namely cucurbit[7]uril (CB7)/acridine orange (AO) is applied and the potential of tandem assays for inhibitor screening is demonstrated
diagnostics
food industry
medicine
pharmacology
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clinical impact of a commercial radioimmunoassay for determination of DAO activity for the diagnosis of histamine intolerance is evaluated in a prospective, multicentre study in 207 adult patients. No correlation between diamine oxidase serum levels and clinical status is be found
diagnostics
a research prototype ELISA is able to reliably and accurately quantify the human enzyme in different biological fluids. The potential of diamine oxidase as biomarker in various diseases can be evaluated
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determination of fresh plasma diamine oxidase activity may serve as an effective tool to diagnose Cu deficiency in the bovine
medicine
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histaminase exerts a clear-cut protective effect in splanchnic artery occlusion/reperfusion-induced splanchnic injury, likely caused by oxidative catabolism of proinflammatory histamine and antioxidant effects resulting in hindrance of free radicalYmediated tissue injury, endothelial dysfunction, and leukocyte recruitment. Histaminase could be used therapeutically in intestinal ischemia
medicine
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the balance between histamine and DAO seems to be crucial for an uncomplicated course of pregnancy. Reduced DAO activities are found in multiple heterogeneous complications of pregnancy such as diabetes, threatened and missed abortion and trophoblastic disorders. Low activities of the histamine-degrading enzyme DAO might indicate high-risk pregnancies, although high intra- and interindividual variations limit its value as a screening tool
medicine
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excess of histamine in gut lumen generates a pronounced gastrointestinal discomfort, which may include diarrhea and peristalsis dysfunctions. Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles
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formulation of vegetal diamine oxidase as a food supplement for the prevention of food allergy and treatment of enteric dysfunction. Study on the stability of diamine oxidase, purified from Lathyrus sativus seedlings, in various simulated intestinal media is reported. The catalytic activity of different diamine oxidase concentrations is tested in simulated intestinal media with different pH and containing cholic acids, pancreatic bicarbonate, and proteases or exogenous food- and drink-derived items, such as lipids or alcohol, alone or in combination
pharmacology
improved food supplements must be developed to help histamine intolerant humans. At least 50 nkat free porcine diamine oxidase are required to convert 75 mg histamine to (imidazol-4-yl)acetaldehyde in an in vitro test system. This results in a reduction of histamine by 90%. The enzyme showes weak stability under simulated intestinal conditions with a half-life period of around 19 min. Therefore, a lot more exogenous diamine oxidase would be required for efficient histamine degradation in the human intestine