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1.4.3.3: D-amino-acid oxidase

This is an abbreviated version!
For detailed information about D-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.4.3.3

Reaction

a D-amino acid
+
H2O
 +
O2
=
a 2-oxo carboxylate
 +
NH3
 +
H2O2

Synonyms

chDAO, D-AAO, D-amino acid oxidase, D-amino-acid-oxidase, D-aminoacid oxidase, DAAO, DAMOX, DAO, DAO1, DaoE, hDAAO, ophio-amino-acid oxidase, oxidase, D-amino acid, PEG-DAO, pkDAAO, RgDAAO, TvDAAO, TvDAO,  LH99

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.3 D-amino-acid oxidase

Expression

Expression on EC 1.4.3.3 - D-amino-acid oxidase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
DAO activity and expression are decreased in thoracic and lumbar regions of spinal cord in aged mice when compared with young mice
DL-Ala induces the enzyme
enzyme activity and expression are increased in schizophrenia patients
-
enzyme activity is increased until the final tadpole stage
-
enzyme activity is reduced to one-third in the adult
-
enzyme expression is increased in schizophrenia
-
higher level of DAO expression is observed in schizophrenic choroid plexus epithelial cells than that in non-schizophrenic cases
-
L5/L6 spinal nerve ligation in the lumbar spinal cord increases the enzyme expression correlated with an increase in neuropathic pain, mechanical allodynia
-
lactose induces the enzyme