1.4.3.3: D-amino-acid oxidase
This is an abbreviated version!
For detailed information about D-amino-acid oxidase, go to the full flat file.
Word Map on EC 1.4.3.3
-
1.4.3.3
-
d-serine
-
schizophrenia
-
peroxisomal
-
flavin
-
n-methyl-d-aspartate
-
d-alanine
-
catalase
-
fad
-
nmda
-
deamination
-
benzoate
-
flavoenzyme
-
flavoproteins
-
racemase
-
variabilis
-
l-amino
-
neurotransmission
-
d-aspartate
-
gracilis
-
co-agonist
-
rhodotorula
-
cephalosporin
-
glutamatergic
-
urate
-
d-proline
-
d-ala
-
d-ser
-
imino
-
antipsychotic
-
hypofunction
-
d-methionine
-
isoalloxazine
-
acylase
-
fad-containing
-
toruloides
-
rhodosporidium
-
d-glutamate
-
fad-dependent
-
d-cysteine
-
kynurenic
-
sulfurtransferase
-
d-valine
-
synthesis
-
medicine
-
d-leucine
-
cerium
-
7-aminocephalosporanic
-
d-tryptophan
-
d-phenylalanine
-
neuregulin
-
3-mercaptopyruvate
-
sarcosine
-
industry
-
biotechnology
-
analysis
-
diagnostics
-
drug development
-
pharmacology
- 1.4.3.3
- d-serine
-
schizophrenia
- peroxisomal
- flavin
- n-methyl-d-aspartate
- d-alanine
- catalase
- fad
- nmda
-
deamination
- benzoate
-
flavoenzyme
- flavoproteins
- racemase
- variabilis
-
l-amino
-
neurotransmission
- d-aspartate
- gracilis
-
co-agonist
- rhodotorula
- cephalosporin
-
glutamatergic
- urate
- d-proline
- d-ala
- d-ser
-
imino
-
antipsychotic
-
hypofunction
- d-methionine
- isoalloxazine
- acylase
-
fad-containing
- toruloides
- rhodosporidium
- d-glutamate
-
fad-dependent
- d-cysteine
-
kynurenic
- sulfurtransferase
- d-valine
- synthesis
- medicine
- d-leucine
- cerium
-
7-aminocephalosporanic
- d-tryptophan
- d-phenylalanine
- neuregulin
- 3-mercaptopyruvate
- sarcosine
- industry
- biotechnology
- analysis
- diagnostics
- drug development
- pharmacology
Reaction
Synonyms
chDAO, D-AAO, D-amino acid oxidase, D-amino-acid-oxidase, D-aminoacid oxidase, DAAO, DAMOX, DAO, DAO1, DaoE, hDAAO, ophio-amino-acid oxidase, oxidase, D-amino acid, PEG-DAO, pkDAAO, RgDAAO, TvDAAO, TvDAO, LH99
ECTree
1.4.3.3 D-amino-acid oxidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.4.3.3 - D-amino-acid oxidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(1R)-1-(2-naphthyl)ethylamine + H2O + O2
1-(naphthalen-2-yl)ethan-1-one + NH3 + H2O2
substrate of mutant Y228L/F242I/R283G
-
-
?
(1R)-1-phenylpropan-1-amine + H2O + O2
1-phenylpropan-1-one + NH3 + H2O2
mutant Y228L/R283G, 109% of the activity with (1R)-1-phenylethan-1-amine
-
-
?
(R)-alpha-methylbenzylamine + H2O + O2
alpha-methylbenzaldehyde + NH3 + H2O2
substrate of mutant Y228L/R283G, the neutral amine is the substrate
-
-
?
(RS)-1-(4-chlorophenyl)-1-phenylmethanamine + H2O + O2
(4-chlorophenyl)(phenyl)methanone + NH3 + H2O2
no substrate of wild-type
-
-
?
1,1-diphenylmethanamine + H2O + O2
diphenylmethanone + NH3 + H2O2
no substrate of wild-type
-
-
?
1-(4-fluorophenyl)ethan-1-amine + H2O + O2
1-phenylethan-1-one + NH3 + H2O2
mutant Y228L/R283G, 22.7% of the activity with (1R)-1-phenylethan-1-amine
-
-
?
3,4-dihydroxy-D-phenylalanine + H2O + O2
3,4-dihydroxyphenylpyruvate + NH3 + H2O2
-
-
-
-
?
4-fluoro-D-Phe + H2O + O2
4-fluorophenylpyruvate + NH3 + H2O2
82% activity compared to D-Met
-
-
?
4-fluoro-DL-phenylalanine + H2O + O2
4-fluoro-phenylpyruvate + NH3 + H2O2
81% activity compared to D-methionine
-
-
?
cephalosporin C
alpha-ketoadipinyl-7-aminocephalosporanic acid
-
-
-
-
?
cephalosporin C + H2O + O2
7-aminocephalosporanic acid + ? + H2O2
conversion of cephalosporin C to 7-aminocephalosporanic acid and spontaneous decarboxylation of oxoadipyl-7-amino cephalosporanic acid is promoted by the H2O2 formed in the oxidase reaction of TvDAO
-
-
?
D-2-chloro-phenylglycine + H2O + O2
(2-chlorophenyl)acetic acid + NH3 + H2O2
-
-
-
?
D-2-fluoro-phenylglycine + H2O + O2
(2-fluorophenyl)acetic acid + NH3 + H2O2
-
-
-
?
D-4-chloro-phenylglycine + H2O + O2
(4-chlorophenyl)acetic acid + NH3 + H2O2
-
-
-
?
D-4-fluoro-phenylglycine + H2O + O2
(4-fluorophenyl)acetic acid + NH3 + H2O2
-
-
-
?
D-4-hydroxy-phenylglycine + H2O + O2
(4-hydroxyphenyl)acetic acid + NH3 + H2O2
-
-
-
?
D-alanine + 2,6-dichlorophenolindophenol + H2O
pyruvate + reduced 2,6-dichlorophenolindophenol + H2O2
-
-
-
-
r
D-alanine + oxidized methylene blue + H2O
pyruvate + reduced methylene blue + H2O2
-
-
-
-
r
D-allo-isoleucine + H2O + O2
(3R)-3-hydroxy-2-oxobutanoate + NH3 + H2O2
-
-
-
?
D-allo-isoleucine + H2O + O2
?
1.0% activity compared to D-methionine
-
-
?
D-amino acid + H2O + O2
a 2-oxo carboxylate + NH3 + H2O2
-
-
-
-
ir
D-aspartate + H2O + O2
? + NH3 + H2O2
recombinant maltose-binding protein-fusion DAAO
-
-
?
D-citrulline + H2O + O2
2-oxo-5-ureidopentanoate + NH3 + H2O2
-
-
-
-
r
D-citrulline + H2O + O2
2-oxo-5-ureidopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-Cys + H2O + O2
2-oxo-3-sulfanylpropionate + NH3 + H2O2
-
1% of the activity with D-Met
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
?
D-lysine + H2O + O2
6-amino-2-oxohexanoate + NH3 + H2O2
-
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
best substrate
-
-
?
D-methionine + 2,6-dichloroindophenol
4-methylsulfanyl-2-oxobutanoate + reduced 2,6-dichloroindophenol
D-methionine + H2O + O2
2-oxo-4-methylthiobutyric acid + NH3 + H2O2
-
-
-
-
ir
D-methionine + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
highly active
-
-
?
D-naphthylalanine + H2O + O2
naphthylpyruvate + NH3 + H2O2
-
-
-
?
D-Orn + H2O + O2
5-amino-2-oxopentanoate + NH3 + H2O2
34% activity compared to D-Met
-
-
?
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvate + NH3 + H2O2
-
-
-
?
D-valine + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
-
highly active
-
-
?
DL-2-naphthyl-alanine + H2O + O2
L-2-naphthyl-alanine + 2-naphthylpyruvic acid + NH3 + H2O2
-
-
-
-
ir
DL-homophenylalanine + H2O + O2
homophenylpyruvate + NH3 + H2O2
31% activity compared to D-methionine
-
-
?
DL-tert-leucine + H2O + O2
?
0.12% activity compared to D-methionine
-
-
?
epsilon-N-benzoyl-D-lysine + H2O + O2
6-benzylamino-2-oxohexanoate + NH3 + H2O2
-
-
-
-
?
N-methyl-D-aspartate + H2O + O2
?
wild-type enzyme shows no activity, mutant enzyme M213R is active
-
-
?
N-methyl-D-aspartate + H2O + O2
oxaloacetate + methylamine + H2O2
-
-
-
?
N-methyl-DL-Leu + H2O + O2
4-methyl-2-oxopentanoate + methylamine + H2O2
5.8% activity compared to D-Met
-
-
?
N-methyl-DL-leucine + H2O + O2
?
2.1% activity compared to D-methionine
-
-
?
O-methyl-DL-serine + H2O + O2
?
0.33% activity compared to D-methionine
-
-
?
(1R)-1-phenylethan-1-amine + H2O + O2
1-phenylethan-1-one + NH3 + H2O2
no substrate of wild-type
-
-
?
(1R)-1-phenylethan-1-amine + H2O + O2
1-phenylethan-1-one + NH3 + H2O2
no substrate of wild-type, but mutant Y228L/R283G
-
-
?
a D-amino acid + H2O + O2
a 2-oxo acid + NH3 + H2O2
-
D-amino-acid oxidase catalyzes the oxidative deamination of D-amino acids, stereoisomers of the naturally occurring L-amino acids
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
1% of the activity with D-Met
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
1% of the activity with D-Ala
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
ir
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
2% of the activity with D-Met
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
36% activity compared to D-alanine
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
13% of the activity with D-Val
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
14% activity compared to D-alanine
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
-
?
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
-
-
-
?
D-3,4-dihydroxyphenylalanine + H2O + O2
?
-
D-Dopa undergoes unidirectional chiral inversion and further suggest that D-Dopa is first oxidatively deaminated by DAAO to its alpha-keto acid and then transaminated by dopa transaminase to L-Dopa
-
-
?
D-Ala + H2O + O2
pyruvate + NH3 + H2O2
-
57% of the activity with D-Met
-
-
?
D-Ala + H2O + O2
pyruvate + NH3 + H2O2
-
-
-
-
?
D-Ala + H2O + O2
pyruvate + NH3 + H2O2
-
71% of the activity with D-Met
-
-
?
D-Ala + H2O + O2
pyruvate + NH3 + H2O2
-
104% activity compared to D-Ser
-
-
?
D-Ala + H2O + O2
pyruvate + NH3 + H2O2
1.6% activity compared to D-Val
-
-
?
D-Ala + H2O + O2
pyruvate + NH3 + H2O2
-
-
-
-
?
D-Ala + H2O + O2
pyruvate + NH3 + H2O2
-
97% of the activity with D-Val
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
-
enzyme works as a metabolizing agent of exogenous and endogenous free D-Ala that is abundant in aquatic invertebrates such as crustaceans and bivalve mollusks, which are potential food sources of the fish. After oral administration of D-Ala at 0.005 mM/g body weight per day to carp for 30 days, enzyme activity increases by about 8fold, 3fold, and 1.5fold in intestine, hepatopancreas, and kidney, respectively, whereas no increase is found in brain
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
the inducible enzyme plays an important physiological role in metabolizing exogenous D-Ala that is abundant in their prey invertebrates, crustaceans, and mollusks
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
0.26% activity compared to D-methionine
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
-
-
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
the D-amino acid is a modulator of the N-methyl-D-aspartate receptor mediated neurotransmission
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
-
-
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
-
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
-
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
-
5.8% activity in tadpoles compared to D-proline
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
recombinant maltose-binding protein-fusion DAAO
-
-
?
D-alanine + H2O + O2
pyruvic acid + NH3 + H2O2
-
-
-
-
?
D-alanine + H2O + O2
pyruvic acid + NH3 + H2O2
-
-
-
-
?
D-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
via formation of an imino acid
-
-
?
D-amino acid + H2O + O2
2-oxocarboxylate + NH3 + H2O2
-
-
-
-
?
D-Arg + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
25% of the activity with D-Ala
-
-
?
D-Arg + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
7% of the activity with D-Ala
-
-
?
D-Arg + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
2% of the activity with D-Met
-
-
?
D-Arg + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
1.1% activity compared to D-Val
-
-
?
D-Arg + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
4% of the activity with D-Pro
-
-
?
D-Arg + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
43% of the activity with D-Val
-
-
?
D-Arg + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
76% activity compared to D-Met
-
-
?
D-Arg + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
-
-
-
-
r
D-arginine + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
80% activity compared to D-methionine
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
19% activity compared to D-alanine
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
-
42% activity compared to D-alanine
-
-
?
D-Asn + H2O + O2
2-oxosuccinamate + NH3 + H2O2
-
2% of the activity with D-Ala
-
-
?
D-Asn + H2O + O2
2-oxosuccinamate + NH3 + H2O2
-
3% of the activity with D-Ala
-
-
?
D-Asn + H2O + O2
2-oxosuccinamate + NH3 + H2O2
-
40% of the activity with D-Met
-
-
?
D-Asn + H2O + O2
2-oxosuccinamate + NH3 + H2O2
-
65% of the activity with D-Val
-
-
?
D-Asn + H2O + O2
2-oxosuccinamate + NH3 + H2O2
0.18% of the activity with D-Ala
-
-
?
D-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
-
7% of the activity with D-Met
-
-
?
D-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
-
5.5% activity compared to D-Ser
-
-
?
D-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
-
38.6% activity compared to D-Ser
-
-
?
D-asparagine + H2O + O2
2-oxosuccinamic acid + NH3 + H2O2
-
-
-
-
?
D-asparagine + H2O + O2
2-oxosuccinamic acid + NH3 + H2O2
-
38% activity compared to D-alanine
-
-
?
D-asparagine + H2O + O2
2-oxosuccinamic acid + NH3 + H2O2
-
67% activity compared to D-alanine
-
-
?
D-aspartate + H2O + O2
oxaloacetate + NH3 + H2O2
-
3% activity compared to D-alanine
-
-
?
D-aspartate + H2O + O2
oxaloacetate + NH3 + H2O2
-
2% activity compared to D-alanine
-
-
?
D-aspartate + H2O + O2
oxaloacetate + NH3 + H2O2
-
1.0% activity in tadpoles compared to D-proline
-
-
?
D-cysteine + H2O + O2
2-oxo-3-sulfanylpropionate + NH3 + H2O2
-
-
-
?
D-cysteine + H2O + O2
2-oxo-3-thiopropionic acid + NH3 + H2O2
-
-
-
-
?
D-cysteine + H2O + O2
2-oxo-3-thiopropionic acid + NH3 + H2O2
-
18% activity compared to D-alanine
-
-
?
D-cysteine + H2O + O2
2-oxo-3-thiopropionic acid + NH3 + H2O2
-
9% activity compared to D-alanine
-
-
?
D-DOPA + H2O + O2
3,4-dihydroxyphenylpyruvic acid + NH3 + H2O2
the maximal velocity for oxidation of D-DOPA is much greater than for D-serine
-
-
?
D-ethionine + H2O + O2
4-ethylsulfanyl-2-oxobutyric acid + NH3 + H2O2
-
-
-
-
?
D-ethionine + H2O + O2
4-ethylsulfanyl-2-oxobutyric acid + NH3 + H2O2
-
-
-
-
?
D-Gln + H2O + O2
2-oxoglutaramate + NH3 + H2O2
-
51% of the activity with D-Met
-
-
?
D-Gln + H2O + O2
2-oxoglutaramate + NH3 + H2O2
-
5% of the activity with D-Ala
-
-
?
D-Gln + H2O + O2
2-oxoglutaramate + NH3 + H2O2
-
15% of the activity with D-Ala
-
-
?
D-Gln + H2O + O2
2-oxoglutaramate + NH3 + H2O2
-
53% of the activity with D-Met
-
-
?
D-Gln + H2O + O2
2-oxoglutaramate + NH3 + H2O2
1.0% activity compared to D-Val
-
-
?
D-Gln + H2O + O2
2-oxoglutaramate + NH3 + H2O2
-
1% of the activity with D-Pro
-
-
?
D-Gln + H2O + O2
2-oxoglutaramate + NH3 + H2O2
-
81% of the activity with D-Val
-
-
?
D-Glu + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
-
10% of the activity with D-Met
-
-
?
D-Glu + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
-
54% of the activity with D-Ala
-
-
?
D-Glu + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
-
4% of the activity with D-Met
-
-
?
D-Glu + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
5.1% activity compared to D-Val
-
-
?
D-Glu + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
-
4% of the activity with D-Pro
-
-
?
D-Glu + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
-
9% of the activity with D-Val
-
-
?
D-glutamate + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
-
3% activity compared to D-alanine
-
-
?
D-glutamate + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
-
9% activity compared to D-alanine
-
-
?
D-glutamine + H2O + O2
2-oxoglutaramate + NH3 + H2O2
-
58% activity compared to D-alanine
-
-
?
D-glutamine + H2O + O2
2-oxoglutaramate + NH3 + H2O2
-
78% activity compared to D-alanine
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
4% of the activity with D-Ala
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
14% of the activity with D-Ala
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
58% of the activity with D-Met
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
3.6% activity compared to D-Val
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
3% of the activity with D-Pro
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
-
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
-
88% of the activity with D-Val
-
-
?
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
12% activity compared to D-Met
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
5.9% activity compared to D-methionine
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
60% activity compared to D-alanine
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
-
-
-
?
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
-
69% activity compared to D-alanine
-
-
?
D-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
15% of the activity with D-Met
-
-
?
D-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
19% of the activity with D-Ala
-
-
?
D-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
56% of the activity with D-Met
-
-
?
D-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
26.7% activity compared to D-Val
-
-
?
D-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
35% of the activity with D-Pro
-
-
?
D-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
76% of the activity with D-Val
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
60% activity compared to D-alanine
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
-
69% activity compared to D-alanine
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
42% of the activity with D-Met
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
92% of the activity with D-Ala
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
29% of the activity with D-Ala
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
57% of the activity with D-Met
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
27.2% activity compared to D-Val
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
21% of the activity with D-Pro
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
-
32% of the activity with D-Val
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
26% activity compared to D-Met
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
7% of the activity with D-Ala
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
best substrate
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
12% activity compared to D-methionine
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
86% activity compared to D-alanine
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
37% activity compared to D-alanine
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
2.3% activity in tadpoles compared to D-proline
-
-
?
D-Lys + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
2.4% activity compared to D-Val
-
-
?
D-Lys + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
90% activity compared to D-Met
-
-
?
D-lysine + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
99% activity compared to D-methionine
-
-
?
D-lysine + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
8% activity compared to D-alanine
-
-
?
D-lysine + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
poor substrate
-
-
?
D-lysine + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
-
7% activity compared to D-alanine
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
best substrate
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
28% of the activity with D-Ala
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
best substrate
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
2.0% activity compared to D-Val
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
-
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
75% of the activity with D-Pro
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
-
78% of the ativity with D-Val
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
100% activity
-
-
?
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
14% of the activity with D-Ala
-
-
?
D-methionine + 2,6-dichloroindophenol
4-methylsulfanyl-2-oxobutanoate + reduced 2,6-dichloroindophenol
-
-
-
-
?
D-methionine + 2,6-dichloroindophenol
4-methylsulfanyl-2-oxobutanoate + reduced 2,6-dichloroindophenol
-
-
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
with 6-dichloroindophenol as electron acceptor
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
with 6-dichloroindophenol as electron acceptor
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
100% activity
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
113% activity compared to D-alanine
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
best substrate
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
77% activity compared to D-alanine
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
by far best substrate
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
7.6% activity in tadpoles compared to D-proline
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
-
-
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
best substrate
-
-
?
D-ornithine + H2O + O2
5-amino-2-oxopentanoate + NH3 + H2O2
15% activity compared to D-methionine
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
-
50% of the activity with D-Met
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
-
19% of the activity with D-Ala
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
-
41% of the activity with D-Ala
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
-
79% of the activity with D-Met
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
2.1% activity compared to D-Val
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
-
84% of the activity with D-Pro
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
-
36% of the activity with D-Val
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
51% activity compared to D-Met
-
-
?
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
1.5% of the activity with D-Ala
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
54% activity compared to D-methionine
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
80% activity compared to D-methionine
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
-
conversion of D-phenylalanine to 99.0% phenylpyruvate within 100 min
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
-
94% activity compared to D-alanine
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
-
44% activity compared to D-alanine
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
-
second best substrate
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
-
activity of the DAAO after incubation in water-insoluble ionic liquids is higher than in water-soluble ones
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
-
activity of the DAAO after incubation in water-insoluble ionic liquids is higher than in water-soluble ones
-
-
?
D-phenylglycine + H2O + O2
benzoylformic acid + NH3 + H2O2
-
-
-
?
D-proline + H2O + O2
2-oxopentanoate + NH3 + H2O2
best substrate
-
-
?
D-proline + H2O + O2
2-oxopentanoate + NH3 + H2O2
-
best substrate, 100% activity in tadpoles and adults
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
4% of the activity with D-Met
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
41% of the activity with D-Ala
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
22% of the activity with D-Ala
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
0.25% activity compared to D-methionine
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
best substrate
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
57% of the activity with D-Met
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
46% activity compared to D-alanine
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
-
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
25% of the activity with D-Val
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
21% activity compared to D-alanine
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
-
1.1% activity in tadpoles compared to D-proline
-
-
?
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
1.4% of the activity with D-Ala
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
9% of the activity with D-Met
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
6% of the activity with D-Ala
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
18% of the activity with D-Ala
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
100% activity
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
41% of the activity with D-Met
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
1.3% activity compared to D-Val
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
18% of the activity with D-Pro
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
22% of the activity with D-Val
-
-
?
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
32% of the activity with D-Ala
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
D-serine, an endogenous agonist of the N-methyl-D-aspartate, NMDA, receptors, is effective in the treatment of schizophrenia. However, orally administered D-serine is metabolized substantially by D-amino acid oxidase diminishing its oral bioavailability
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
metabolizaation of the N-methyl D-aspartate receptor co-agonist
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
the apoprotein form of hDAAO binds the substrate D-serine, which increases FAD binding thus increasing the amount of active holoenzyme in solution
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
low catalytic efficiency and substrate affinity on the physiological substrate D-serine
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
physiological effects of D-serine, overview
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
the D-amino acid is a modulator of the N-methyl-D-aspartate receptor mediated neurotransmission
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
physiological effects of D-serine, overview
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
high doses of D-serine attenuate both amphetamine-induced psychomotor activity and dopamine release and also improve performance in novel object recognition
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
-
poor substrate
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
astroglial enzyme plays an important role in metabolizing a neuromodulator, D-serine
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
49% activity compared to D-alanine
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
23% activity compared to D-alanine
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
7.6% activity in tadpoles compared to D-proline
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
-
-
?
D-Thr + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
11.5% activity compared to D-Val
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
2% of the activity with D-Ala
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
10% of the activity with D-Met
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
2% of the activity with D-Pro
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
poor substrate
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
-
4% of the activity with D-Val
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
1.2% of the activity with D-Ala
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyric acid + NH3 + H2O2
-
-
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyric acid + NH3 + H2O2
-
18% activity compared to D-alanine
-
-
?
D-threonine + H2O + O2
2-oxo-3-hydroxybutyric acid + NH3 + H2O2
-
2% activity compared to D-alanine
-
-
?
D-Trp + H2O + O2
indol-3-pyruvate + NH3 + H2O2
-
9% of the activity with D-Ala
-
-
?
D-Trp + H2O + O2
indol-3-pyruvate + NH3 + H2O2
-
14% of the activity with D-Ala
-
-
?
D-Trp + H2O + O2
indol-3-pyruvate + NH3 + H2O2
-
56% of the activity with D-Met
-
-
?
D-Trp + H2O + O2
indol-3-pyruvate + NH3 + H2O2
1.5% activity compared to D-Val
-
-
?
D-Trp + H2O + O2
indol-3-pyruvate + NH3 + H2O2
-
2% of the activity with D-Pro
-
-
?
D-Trp + H2O + O2
indol-3-pyruvate + NH3 + H2O2
-
38% of the activity with D-val
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvate + NH3 + H2O2
-
92% activity compared to D-alanine
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvate + NH3 + H2O2
-
129% activity compared to D-alanine
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvic acid + NH3 + H2O2
-
-
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvic acid + NH3 + H2O2
-
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvic acid + NH3 + H2O2
-
-
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvic acid + NH3 + H2O2
-
-
-
?
D-tryptophan + H2O + O2
indole-3-pyruvic acid + NH3 + H2O2
-
DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid
-
-
?
D-tryptophan + H2O + O2
indole-3-pyruvic acid + NH3 + H2O2
DAAO catalyzes the production of aryl hydrocarbon receptor, AHR, agonists through the enzymatic conversion of D-tryptophan to indole-3-pyruvic acid
-
-
?
D-Tyr + H2O + O2
4-hydroxyphenylpyruvate + NH3 + H2O2
17.6% activity compared to D-Val
-
-
?
D-Tyr + H2O + O2
4-hydroxyphenylpyruvate + NH3 + H2O2
11.6% activity compared to D-Met
-
-
?
D-Tyr + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
6% of the activity with D-Ala
-
-
?
D-Tyr + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
8% of the activity with D-Ala
-
-
?
D-Tyr + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
26% of the activity with D-Met
-
-
?
D-Tyr + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
4% of the activity with D-Pro
-
-
?
D-Tyr + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
17% of the activity with D-Val
-
-
?
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
4.7% activity compared to D-methionine
-
-
?
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
18% activity compared to D-alanine
-
-
?
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
-
-
-
?
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
-
19% activity compared to D-alanine
-
-
?
D-Val + H2O + O2
2-oxoisovalerate + NH3 + H2O2
100% activity
-
-
?
D-Val + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
-
41% of the activity with D-Met
-
-
?
D-Val + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
-
15% of the activity with D-Ala
-
-
?
D-Val + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
-
62% of the activity with D-Ala
-
-
?
D-Val + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
-
95% of the activity with D-Met
-
-
?
D-Val + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
-
28% of the activity with D-Pro
-
-
?
D-Val + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
-
best substrate
-
-
?
D-Val + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
8% of the activity with D-Ala
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
0.35% activity compared to D-methionine
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
-
-
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
best substrate
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
-
60% activity compared to D-alanine
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
-
-
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
-
-
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
-
63% activity compared to D-alanine
-
-
?
Gly + H2O + O2
acetate + NH3 + H2O2
-
2% of the activity with D-Met
-
-
?
Gly + H2O + O2
acetate + NH3 + H2O2
-
15% of the activity with D-Ala
-
-
?
Gly + H2O + O2
acetate + NH3 + H2O2
-
3% of the activity with D-Met
-
-
?
Gly + H2O + O2
acetate + NH3 + H2O2
1.1% activity compared to D-Val
-
-
?
glycine + 2 H2O + O2
2 formic acid + NH3 + H2O2
-
3% activity compared to D-alanine
-
-
?
glycine + 2 H2O + O2
2 formic acid + NH3 + H2O2
-
poor substrate
-
-
?
glycine + 2 H2O + O2
2 formic acid + NH3 + H2O2
-
2% activity compared to D-alanine
-
-
?
thiazolidine-2-carboxylic acid + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
additional information
?
-
-
DAO shows no activity with D-Asp, N-methyl-D-Asp, and D-Glu
-
-
?
additional information
?
-
DAAOs can be divided into two groups regarding their substrate specificity, the first group prefers amino acids with small apolar side chains (D-Ala is the best substrate), the second group prefers D-amino acids possessing large hydrophobic side chains such as D-Trp, D-Met, D-Val, and D-Phe, usually the small amino acid Gly and the charged (acidic or basic) amino acids are poor DAAO substrates
-
-
?
additional information
?
-
DAAOs can be divided into two groups regarding their substrate specificity, the first group prefers amino acids with small apolar side chains (D-Ala is the best substrate), the second group prefers D-amino acids possessing large hydrophobic side chains such as D-Trp, D-Met, D-Val, and D-Phe, usually the small amino acid Gly and the charged (acidic or basic) amino acids are poor DAAO substrates
-
-
?
additional information
?
-
no activity with glycine, D-serine, D-asparagine, D-aspartate, D-glutamate, D-threonine, D-tryptophan, and cephalosporin C
-
-
?
additional information
?
-
-
no activity with glycine, D-serine, D-asparagine, D-aspartate, D-glutamate, D-threonine, D-tryptophan, and cephalosporin C
-
-
?
additional information
?
-
D-aspartate and D-glutamate are no substrates
-
-
?
additional information
?
-
-
D-aspartate and D-glutamate are no substrates
-
-
?
additional information
?
-
-
DAAO is a catabolic flavoenzyme that catalyzes the oxidative deamination of D-amino acids to the corresponding a-keto acids, hydrogen peroxide, and ammonia. DAAO is strictly specific for D-isomers of amino acids
-
-
?
additional information
?
-
-
the mechanism of the enzyme regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects, overview
-
-
?
additional information
?
-
-
D-amino acid oxidase is a flavoenzyme that catalyzes the oxidation of D-amino acids to the corresponding imino acids and hydrogen peroxide
-
-
?
additional information
?
-
-
hDAAO exhibits optimal activity toward neutral D-amino acids and marginal activity toward basic ones, while acidic D-amino acids are not oxidized, structure-function relationship analysis, overview
-
-
?
additional information
?
-
-
the enzyme catalyzes oxidative deamination of D-amino acids yielding hydrogen peroxide and an imino acid. The latter is further non-enzymatically hydrolyzed to an alpha-keto acid and ammonium. DAAO is highly specific towards D-isomers of amino acids, it is almost inactive towards the corresponding L-isomer
-
-
?
additional information
?
-
DAAO interacts with its physiological partner pLG72, the interaction is not inhibited by benzoate and chlorpromazine
-
-
?
additional information
?
-
-
DAAO interacts with its physiological partner pLG72, the interaction is not inhibited by benzoate and chlorpromazine
-
-
?
additional information
?
-
comparison of the kinetics of trypsin cleavage of hDAAO in the presence of various ligands, overview
-
-
?
additional information
?
-
-
comparison of the kinetics of trypsin cleavage of hDAAO in the presence of various ligands, overview
-
-
?
additional information
?
-
DAAO is mainly active on neutral, hydrophobic and slightly polar D-amino acids and shows a preference for aromatic amino acids
-
-
-
additional information
?
-
-
DAAO is mainly active on neutral, hydrophobic and slightly polar D-amino acids and shows a preference for aromatic amino acids
-
-
-
additional information
?
-
-
the amount of the neutral D-amino acids are regulated, each D-amino acid is regulated in a different way
-
-
?
additional information
?
-
-
DAO catalyzes the oxidative degradation of most of the D-amino acids in mammals
-
-
?
additional information
?
-
DAAOs can be divided into two groups regarding their substrate specificity, the first group prefers amino acids with small apolar side chains (D-Ala is the best substrate), the second group prefers D-amino acids possessing large hydrophobic side chains such as D-Trp, D-Met, D-Val, and D-Phe, usually the small amino acid Gly and the charged (acidic or basic) amino acids are poor DAAO substrates
-
-
?
additional information
?
-
no substrates: L-isoleucine, L-valine, L-methionine
-
-
-
additional information
?
-
-
no substrates: L-isoleucine, L-valine, L-methionine
-
-
-
additional information
?
-
-
D-amino acid oxidase is an enzyme catalyzing the strict stereospecificity the oxidative deamination of neutral and polar D-amino acids to alpha-keto acids, NH3 and hydrogen peroxide
-
-
?
additional information
?
-
D-amino acid oxidase is a flavoenzyme that catalyzes the oxidation of D-amino acids to the corresponding imino acids and hydrogen peroxide
-
-
?
additional information
?
-
-
the flavoenzyme catalyzes the oxidative deamination of neutral and basic D-amino acids to the corresponding 2-oxo acids and H2O2 with concomitant reduction of FAD
-
-
?
additional information
?
-
-
the enzyme interacts with the mammalian protein modulator pLG72
-
-
?
additional information
?
-
-
D-aspartate and glycine are no substrates
-
-
?
additional information
?
-
-
first enzyme involved in the catabolism of D-amino acids. The inducer D-Ala acts by increasing the rate of DAAO mRNA transcription. Ammonium sulfate appears to have a negative effect on DAAO mRNA translation and on the expression of DAAO activity. The best expression of DAAO activity is obtained by growing the cells for 12 h at 30°C in the presence of glucose and D-alanine using cell pre-cultured for 10 h on glucose and L-Ala
-
-
?
additional information
?
-
best substrate is D-valine followed by D-tryptophan, D-phenylalanine, D-alanine, and D-cysteine
-
-
?
additional information
?
-
D-aspartate and D-glutamate are no substrates
-
-
?
additional information
?
-
DAAOs can be divided into two groups regarding their substrate specificity, the first group prefers amino acids with small apolar side chains (D-Ala is the best substrate), the second group prefers D-amino acids possessing large hydrophobic side chains such as D-Trp, D-Met, D-Val, and D-Phe, usually the small amino acid Gly and the charged (acidic or basic) amino acids are poor DAAO substrates
-
-
?
additional information
?
-
the wild-type DAAO is mainly active on neutral D-amino acids, while basic D-amino acids are poor substrates and the acidic ones are virtually not oxidized
-
-
?
additional information
?
-
-
the wild-type DAAO is mainly active on neutral D-amino acids, while basic D-amino acids are poor substrates and the acidic ones are virtually not oxidized
-
-
?
additional information
?
-
the mechanism of the enzyme regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects, overview
-
-
?
additional information
?
-
the enzyme catalyzes oxidative deamination of D-amino acids yielding hydrogen peroxide and an imino acid. The latter is further non-enzymatically hydrolyzed to an alpha-keto acid and ammonium. DAAO is highly specific towards D-isomers of amino acids, it is almost inactive towards the corresponding L-isomer
-
-
?
additional information
?
-
specific dynamic channel for the diffusion of O2 leads from solvent to the flavin Si-side. O2 affinity, catalytic center, and substrate binding of wild-type and mutant enzymes, molecular dynamics simulations built from the three-dimensional structure, PDB ID 1c0p, in which the ligand D-Ala is replaced by imino pyruvate, overview
-
-
?
additional information
?
-
DAAOs can be divided into two groups regarding their substrate specificity, the first group prefers amino acids with small apolar side chains (D-Ala is the best substrate), the second group prefers D-amino acids possessing large hydrophobic side chains such as D-Trp, D-Met, D-Val, and D-Phe, usually the small amino acid Gly and the charged (acidic or basic) amino acids are poor DAAO substrates
-
-
?
additional information
?
-
no activity with D-Pro, D-Cys, D-Asp, L-Val, L-Leu, and L-Ile
-
-
?
additional information
?
-
-
no activity with D-Pro, D-Cys, D-Asp, L-Val, L-Leu, and L-Ile
-
-
?
additional information
?
-
D-aspartate and D-glutamate are no substrates
-
-
?
additional information
?
-
D-proline is the best substrate followed by D-methionine, D-alanine, D-norleucine, D-isoleucine, and D-phenylalanine
-
-
?
additional information
?
-
-
D-proline is the best substrate followed by D-methionine, D-alanine, D-norleucine, D-isoleucine, and D-phenylalanine
-
-
?
additional information
?
-
the enzyme exhibits very low activity towards basic amino acids, and it does not oxidize those with an acidic side chain
-
-
?
additional information
?
-
-
the mechanism of the enzyme regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects, overview
-
-
?
additional information
?
-
-
DAAO is a flavoprotein that catalyzes the dehydrogenation of different D-amino acids to their imino counterparts via a reduced flavin product complex. The reduced flavin is then reoxidized by O2 to yield H2O2, whereas the imino acid spontaneously hydrolyzes to the corresponding keto acid and NH4+. DAAO is strictly stereospecific and oxidizes a variety of D-amino acids, with a preference for those having small hydrophobic side chains, followed by those bearing polar, aromatic, and basic groups
-
-
?
additional information
?
-
-
the enzyme catalyzes oxidative deamination of D-amino acids yielding hydrogen peroxide and an imino acid. The latter is further non-enzymatically hydrolyzed to an alpha-keto acid and ammonium. DAAO is highly specific towards D-isomers of amino acids, it is almost inactive towards the corresponding L-isomer
-
-
?
additional information
?
-
best substrate is by far D-methionine followed by D-phenylalanine, D-tryptophan, D-valin, and D-alanine
-
-
?
additional information
?
-
D-aspartate and D-glutamate are no substrates
-
-
?
additional information
?
-
DAAOs can be divided into two groups regarding their substrate specificity, the first group prefers amino acids with small apolar side chains (D-Ala is the best substrate), the second group prefers D-amino acids possessing large hydrophobic side chains such as D-Trp, D-Met, D-Val, and D-Phe, usually the small amino acid Gly and the charged (acidic or basic) amino acids are poor DAAO substrates
-
-
?
additional information
?
-
-
nearly inactive toward D-aspartic and D-glutamic acids
-
-
?
additional information
?
-
-
the enzyme is involved in the conversion of cephalosporin C
-
-
?
additional information
?
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the mechanism of the enzyme regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects, overview
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the enzyme catalyzes oxidative deamination of D-amino acids yielding hydrogen peroxide and an imino acid. The latter is further non-enzymatically hydrolyzed to an alpha-keto acid and ammonium. DAAO is highly specific towards D-isomers of amino acids, it is almost inactive towards the corresponding L-isomer. The wild-type enzyme is inactive towards D-Asp, being however very active with D-Ala
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conversion of cephalosporine C to 7-aminocephalosporanic acid and spontaneous decarboxylation of oxoadipyl-7-amino cephalosporanic acid is promoted by the H2O2 formed in the oxidase reaction of TvDAO
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conversion of cephalosporine C to 7-aminocephalosporanic acid and spontaneous decarboxylation of oxoadipyl-7-amino cephalosporanic acid is promoted by the H2O2 formed in the oxidase reaction of TvDAO
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D-allo-isoleucine, D-valine, O-methyl-DL-serine, D-alanine, and D-proline are no substrates
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recombinant maltose-binding protein-fusion DAAO can oxidize D-alanine and D-aspartate, but not D-leucine, D-isoleucine, and D-serine
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recombinant maltose-binding protein-fusion DAAO can oxidize D-alanine and D-aspartate, but not D-leucine, D-isoleucine, and D-serine
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no activity with D-Trp, D-Tyr, D-Cys, D-Gln, D-Lys, D-Arg, D-His and D-Asp
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DAAOs can be divided into two groups regarding their substrate specificity, the first group prefers amino acids with small apolar side chains (D-Ala is the best substrate), the second group prefers D-amino acids possessing large hydrophobic side chains such as D-Trp, D-Met, D-Val, and D-Phe, usually the small amino acid Gly and the charged (acidic or basic) amino acids are poor DAAO substrates
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