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1.4.3.5: pyridoxal 5'-phosphate synthase

This is an abbreviated version!
For detailed information about pyridoxal 5'-phosphate synthase, go to the full flat file.

Word Map on EC 1.4.3.5

Reaction

pyridoxamine 5'-phosphate
+
H2O
+
O2
=
pyridoxal 5'-phosphate
+
NH3
+
H2O2

Synonyms

ePNPOx, FprA protein, oxidase, pyridoxamine phosphate, Pdx1, PDX3, PdxH, PMP oxidase, PNP oxidase, PNP/PMP oxidase, PNPO, PNPOx, PPOX, pyridox(am)ine 5'-phosphate oxidase, pyridoxal 5'-phosphate synthase, pyridoxal 5'-phosphate synthetic enzyme, pyridoxamine (pyridoxine) 5'-phosphate oxidase, pyridoxamine (pyridoxine) 5’-phosphate:O2 oxidoreductase (deaminating), pyridoxamine 5'-phosphate oxidase, pyridoxamine phosphate oxidase, pyridoxamine-5-phosphate oxidase, pyridoxamine-phosphate oxidase, pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating), pyridoxinamine 5'-phosphate oxidase, pyridoxine (pyridoxamine) 5 '-phosphate oxidase, pyridoxine (pyridoxamine) 5'-phosphate oxidase, pyridoxine (pyridoxamine) phosphate oxidase, pyridoxine 5'-phosphate oxidase, pyridoxine 5'-phosphate oxidase`, pyridoxine 5-phosphate oxidase, pyridoxine phosphate oxidase, pyridoxine-5'-phosphate oxidase, pyridoxine/pyridoxamine 5'-phosphate oxidase, pyridoxine/pyridoxamine phosphate oxidase, sgll, Sgll/PNPO, Ylr456w, Ypr172w

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.5 pyridoxal 5'-phosphate synthase

Expression

Expression on EC 1.4.3.5 - pyridoxal 5'-phosphate synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme expression is down-regulated by exposure to drought (15%) and NaCl (43%). mRNA levels are also reduced by growth in the dark to 62%. Jasmonic acid treatment slightly decreases (20%) the level of mRNA after 8 h treatment
-
enzyme expression is up-regulated by light, heat shock (80% within 1 h), absicsic acid (43% after 4 h) and ethylene treatments (33% after 8 h)
-
no substantial change in level occurs by exposure to UV irradiation
-
PNPO immunoreactivities are significantly increased in the rat hippocampus accompanied by reductions in paired-pulse inhibition at 1 day and 1 week after status epilepticus
-
the enzyme (PNPO) is down-regulated and up-regulated by miR-216b-5p mimics and inhibitors, respectively, in breast cancer cells
the enzyme (PNPO) is down-regulated and up-regulated by miR-216b-5p mimics and inhibitors, respectively, in breast cancer cells. Knockdown of MALAT1 results in an increase of miR-216b-5p and a decrease of PNPO mRNA, indicating a regulatory mechanism of competing endogenous RNAs
the enzyme is upregulated in patients with invasive ductal carcinoma (IDC) at mRNA and protein levels