1.4.4.2: glycine dehydrogenase (aminomethyl-transferring)
This is an abbreviated version!
For detailed information about glycine dehydrogenase (aminomethyl-transferring), go to the full flat file.
Word Map on EC 1.4.4.2
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1.4.4.2
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coil
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aneurysm
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guglielmi
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embolization
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endovascular
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artery
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measles
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occlusion
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cerebral
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intracranial
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hemagglutinin
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rupture
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neck
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dental
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subarachnoid
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hemorrhage
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photorespiratory
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angiographic
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photorespiration
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council
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distemper
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hyperglycinemia
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dentist
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lipoylation
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hydroxymethyltransferase
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polyomavirus
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angiogram
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t-proteins
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slam
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lipoic
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nonketotic
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rebleeding
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microcatheter
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morbillivirus
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vasospasm
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unruptured
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recanalization
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basilar
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polyoma
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ceria
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glycodeoxycholate
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practise
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procedure-related
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lipoamide
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profession
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flaveria
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lipoate
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panencephalitis
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medicine
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postal
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curriculum
- 1.4.4.2
-
coil
- aneurysm
-
guglielmi
-
embolization
-
endovascular
- artery
- measles
-
occlusion
- cerebral
-
intracranial
- hemagglutinin
-
rupture
- neck
-
dental
-
subarachnoid
- hemorrhage
-
photorespiratory
-
angiographic
-
photorespiration
-
council
- distemper
- hyperglycinemia
-
dentist
-
lipoylation
- hydroxymethyltransferase
- polyomavirus
-
angiogram
-
t-proteins
-
slam
-
lipoic
-
nonketotic
-
rebleeding
-
microcatheter
- morbillivirus
- vasospasm
-
unruptured
-
recanalization
-
basilar
-
polyoma
-
ceria
- glycodeoxycholate
-
practise
-
procedure-related
- lipoamide
-
profession
- flaveria
- lipoate
- panencephalitis
- medicine
-
postal
-
curriculum
Reaction
Synonyms
decarboxylase, glycine, GDC, GDCP, GLDC, GLDH, GLDP, Gly decarboxylase complex, Gly decarboxylase H1, glycine cleavage enzyme complex, glycine cleavage H protein, glycine cleavage system H protein 1, Glycine cleavage system P-protein, glycine decarboxylase, glycine decarboxylase (P-protein), glycine decarboxylase complex, glycine decarboxylase complex H, glycine decarboxylase P-protein, glycine dehydrogenase, glycine dehydrogenase (decarboxylating), glycine-cleavage complex, H protein, H-protein, H1 protein, H2 protein, L protein, More, P protein, P-protein, P-protein (glycine decarboxylase), P-subunit, Protein P1, T protein
ECTree
1.4.4.2 glycine dehydrogenase (aminomethyl-transferring)Advanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 1.4.4.2 - glycine dehydrogenase (aminomethyl-transferring)
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine
[glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2
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r
glycine + H-protein-lipoyllysine
H-protein-S-aminomethyldihydrolipoyllysine + CO2
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-
-
-
?
glycine + H-protein-lipoyllysine
H-protein-S-aminomethyldihydrolipoyllysine + CO2
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-
-
-
?
glycine + H-protein-lipoyllysine
H-protein-S-aminomethyldihydrolipoyllysine + CO2
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-
-
-
?
glycine + H-protein-lipoyllysine
H-protein-S-aminomethyldihydrolipoyllysine + CO2
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-
-
?
glycine + H-protein-lipoyllysine
H-protein-S-aminomethyldihydrolipoyllysine + CO2
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-
-
-
?
glycine + H-protein-lipoyllysine
H-protein-S-aminomethyldihydrolipoyllysine + CO2
P-protein is the actual glycine-decarboxylating enzyme and uses pyridoxal 5'-phosphate as a cofactor. CO2 is released in the reaction and the residual aminomethyl group is bound to the oxidized lipoamide arm of H-protein
the methylene group is accepted by tetrahydrofolate to yield methylene tetrahydrofolate, a major cofactor in one-carbon metabolism
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?
glycine + H-protein-lipoyllysine
H-protein-S-aminomethyldihydrolipoyllysine + CO2
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-
-
-
?
glycine + H-protein-lipoyllysine
H-protein-S-aminomethyldihydrolipoyllysine + CO2
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-
-
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?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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lipoyl protein: H-protein, lipoamide can also act as acceptor
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-
?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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lipoyl protein: H-protein, lipoamide can also act as acceptor
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-
?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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reaction is stimulated by lipoic acid which is a functional group of the H-protein
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?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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glycine decarboxylation catalyzed by P-protein alone is extremely low
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?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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lipoyl protein: H-protein, lipoamide can also act as acceptor
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?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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lipoyl protein: H-protein, lipoamide can also act as acceptor
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-
?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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lipoyl protein: H-protein, lipoamide can also act as acceptor
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-
?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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-
-
-
?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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lipoyl protein: H-protein, lipoamide can also act as acceptor
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-
?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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lipoyl protein: H-protein, lipoamide can also act as acceptor
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-
?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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-
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?
glycine + lipoylprotein
S-aminomethyldihydrolipoylprotein + CO2
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lipoyl protein: H-protein, lipoamide can also act as acceptor
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?
additional information
?
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nonketotic hyperglycinaemia is an autosomal recessive disorder of glycine metabolism caused by a deficiency in the mitochondrial glycine cleavage enzyme. The majority of cases are caused by mutations in the P-protein
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?
additional information
?
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in transgenic potato plants with an antisense reduction in P-protein of GDC, the decrease in photorespiratory decarboxylation is compensated for by an increase in respiratory decarboxylation in the light
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?
