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1.4.4.2: glycine dehydrogenase (aminomethyl-transferring)

This is an abbreviated version!
For detailed information about glycine dehydrogenase (aminomethyl-transferring), go to the full flat file.

Word Map on EC 1.4.4.2

Reaction

glycine
+
[glycine-cleavage complex H protein]-N6-lipoyl-L-lysine
=
[glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine
+
CO2

Synonyms

decarboxylase, glycine, GDC, GDCP, GLDC, GLDH, GLDP, Gly decarboxylase complex, Gly decarboxylase H1, glycine cleavage enzyme complex, glycine cleavage H protein, glycine cleavage system H protein 1, Glycine cleavage system P-protein, glycine decarboxylase, glycine decarboxylase (P-protein), glycine decarboxylase complex, glycine decarboxylase complex H, glycine decarboxylase P-protein, glycine dehydrogenase, glycine dehydrogenase (decarboxylating), glycine-cleavage complex, H protein, H-protein, H1 protein, H2 protein, L protein, More, P protein, P-protein, P-protein (glycine decarboxylase), P-subunit, Protein P1, T protein

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.4 With a disulfide as acceptor
                1.4.4.2 glycine dehydrogenase (aminomethyl-transferring)

Reference

Reference on EC 1.4.4.2 - glycine dehydrogenase (aminomethyl-transferring)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hiraga, K.; Kikuchi, G.
The mitochondrial glycine cleavage system. Purification and properties of glycine decarboxylase from chicken liver mitochondria
J. Biol. Chem.
255
11664-11670
1980
Gallus gallus
Manually annotated by BRENDA team
Walker, J.L.; Oliver, D.J.
Glycine decarboxylase multienzyme complex. Purification and partial characterization from pea leaf mitochondria
J. Biol. Chem.
261
2214-2221
1986
Pisum sativum
Manually annotated by BRENDA team
Freudenberg, W.; Andreesen, J.R.
Purification and partial characterization of the glycine decarboxylase multienzyme complex from Eubacterium acidaminophilum
J. Bacteriol.
171
2209-2215
1989
Peptoclostridium acidaminophilum
Manually annotated by BRENDA team
Fujiwara, K.; Okamura-Ikeda, K.; Motokawa, Y.
Amino acid sequence of the phosphopyridoxyl peptide from P-protein of the chicken liver glycine cleavage system
Biochem. Biophys. Res. Commun.
149
621-627
1987
Gallus gallus
Manually annotated by BRENDA team
Tobin, A.K.; Thorpe, J.R.; Hylton, C.M.; Rawsthorne, S.
Spatial and temporal influences on the cell-specific distribution of glycine decarboxylase in leaves of wheat (Triticum aestivum L.) and pea (Pisum sativum L.)
Plant Physiol.
91
1219-1225
1989
Pisum sativum, Triticum aestivum
Manually annotated by BRENDA team
Freudenberg, W.; Mayer, F.; Andreesen, J.R.
Immunocytochemical localization of proteins P1, P2, P3 of glycine decarboxylase and of the selenoprotein PA of glycine reductase, all involved in anaerobic glycine metabolism of Eubacterium acidaminophilum
Arch. Microbiol.
152
182-188
1989
Peptoclostridium acidaminophilum
-
Manually annotated by BRENDA team
Bourguignon, J.; Neuburger, M.; Douce, R.
Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase
Biochem. J.
255
169-178
1988
Pisum sativum
Manually annotated by BRENDA team
Fujiwara, K.; Okamura-Ikeda, K.; Ohmura, Y.; Motokawa, Y.
Mechanism of the glycine cleavage reaction: retention of C-2 hydrogens of glycine on the intermediate attached to H-protein and evidence for the inability of serine hydroxymethyltransferase to catalyze the glycine decarboxylation
Arch. Biochem. Biophys.
251
121-127
1986
Bos taurus, Gallus gallus
Manually annotated by BRENDA team
Fujiwara, K.; Motokawa, Y.
Mechanism of the glycine cleavage reaction. Steady state kinetic studies of the P-protein-catalyzed reaction
J. Biol. Chem.
258
8156-8162
1983
Gallus gallus
Manually annotated by BRENDA team
Hiraga, K.; Kikuchi, G.
The mitochondrial glycine cleavage system: inactivation of glycine decarboxylase as a side reaction of the glycine decarboxylation in the presence of aminomethyl carrier protein
J. Biochem.
92
1489-1498
1982
Gallus gallus
Manually annotated by BRENDA team
Hiraga, K.; Kikuchi, G.
The mitochondrial glycine cleavage system: differential inhibition by divalent cations of glycine synthesis and glycine decarboxylation in the glycine-CO2 exchange
J. Biochem.
92
937-944
1982
Gallus gallus
Manually annotated by BRENDA team
Hiraga, K.; Kikuchi, G.
The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein
J. Biol. Chem.
255
11671-11676
1980
Gallus gallus
Manually annotated by BRENDA team
Hayasaka, K.; Kochi, H.; Hiraga, K.; Kikuchi, G.
Purification and properties of glycine decarboxylase, a component of the glycine cleavage system, from rat liver mitochondria and immunochemical comparison of this enzyme from various sources
J. Biochem.
88
1193-1199
1980
Rattus norvegicus
Manually annotated by BRENDA team
Klein, S.M.; Sagers, R.D.
Glycine metabolism. I. Properties of the system catalyzing the exchange of bicarbonate with the carboxyl group of glycine in Peptococcus glycinophilus
J. Biol. Chem.
241
197-205
1966
Parvimonas micra
Manually annotated by BRENDA team
Klein, S.M.; Sagers, R.
Glycine metabolism. II. Kinetic and optical studies on the glycine decarboxylase system from Peptococcus glycinophilus
J. Biol. Chem.
241
206-209
1966
Parvimonas micra
Manually annotated by BRENDA team
Motokawa, Y.; Kikuchi, G.
Glycine metabolism by rat liver mitochondria. Reconstruction of the reversible glycine cleavage system with partially purified protein components
Arch. Biochem. Biophys.
164
624-633
1974
Rattus norvegicus
Manually annotated by BRENDA team
Kochi, H.; Kikuchi, G.
Mechanism of the reversible glycine cleavage reaction in Arthrobacter globiformis. I. Purification and function of protein components required for the reaction
J. Biochem.
75
1113-1127
1974
Arthrobacter globiformis
Manually annotated by BRENDA team
Sinclair, D.A.; Hong, S.P.; Dawes, I.W.
Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae
Mol. Microbiol.
19
611-623
1996
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Besson, V.; Rebeille, F.; Neuburger, M.; Douce, R.; Cossins, E.A.
Effects of tetrahydrofolate polyglutamates on the kinetic parameters of serine hydroxymethyltransferase and glycine decarboxylase from pea leaf mitochondria
Biochem. J.
292
425-430
1993
Pisum sativum
-
Manually annotated by BRENDA team
Rebeille, F.; Neuburger, M.; Douce, R.
Interaction between glycine decarboxylase, serine hydroxymethyltransferase and tetrahydrofolate polyglutamates in pea leaf mitochondria
Biochem. J.
302
223-228
1994
Pisum sativum
-
Manually annotated by BRENDA team
Oliver, D.J.; Raman, R.
Glycine decarboxylase: protein chemistry and molecular biology of the major protein in leaf mitochondria
J. Bioenerg. Biomembr.
27
407-414
1995
C3-plants, Pisum sativum
Manually annotated by BRENDA team
Douce, R.; Bourguignon, J.; Macherel, D.; Neuburger, M.
The glycine decarboxylase system in higher plant mitochondria: structure, function and biogenesis
Biochem. Soc. Trans.
22
184-188
1994
C3-plants
Manually annotated by BRENDA team
Zhang, Q.; Wiskich, J.T.
Activation of glycine decarboxylase in pea leaf mitochondria by ATP
Arch. Biochem. Biophys.
320
250-256
1995
Pisum sativum
Manually annotated by BRENDA team
Nakai, T.; Nakagawa, N.; Maoka, N.; Masui, R.; Kuramitsu, S.; Kamiya, N.
Coexpression, purification, crystallization and preliminary X-ray characterization of glycine decarboxylase (P-protein) of the glycine-cleavage system from Thermus thermophilus HB8
Acta Crystallogr. Sect. D
59
554-557
2003
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Manually annotated by BRENDA team
Nakai, T.; Nakagawa, N.; Maoka, N.; Masui, R.; Kuramitsu, S.; Kamiya, N.
Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia
EMBO J.
24
1523-1536
2005
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Manually annotated by BRENDA team
Toone, J.R.; Applegarth, D.A.; Kure, S.; Coulter-Mackie, M.B.; Sazegar, P.; Kojima, K.; Ichinohe, A.
Novel mutations in the P-protein (glycine decarboxylase) gene in patients with glycine encephalopathy (non-ketotic hyperglycinemia)
Mol. Genet. Metab.
76
243-249
2002
Homo sapiens
Manually annotated by BRENDA team
Sellner, L.; Edkins, E.; Greed, L.; Lewis, B.
Detection of mutations in the glycine decarboxylase gene in patients with nonketotic hyperglycinaemia
Mol. Genet. Metab.
84
167-171
2005
Homo sapiens
Manually annotated by BRENDA team
Bykova, N.V.; Keerberg, O.; Parnik, T.; Bauwe, H.; Gardestrom, P.
Interaction between photorespiration and respiration in transgenic potato plants with antisense reduction in glycine decarboxylase
Planta
222
130-140
2005
Solanum tuberosum
Manually annotated by BRENDA team
Mukherjee, M.; Brown, M.T.; McArthur, A.G.; Johnson, P.J.
Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis
Eukaryot. Cell
5
2062-2071
2006
Trichomonas vaginalis
Manually annotated by BRENDA team
Dinopoulos, A.; Kure, S.; Chuck, G.; Sato, K.; Gilbert, D.L.; Matsubara, Y.; Degrauw, T.
Glycine decarboxylase mutations: a distinctive phenotype of nonketotic hyperglycinemia in adults
Neurology
64
1255-1257
2005
Homo sapiens
Manually annotated by BRENDA team
Hagemann, M.; Vinnemeier, J.; Oberpichler, I.; Boldt, R.; Bauwe, H.
The glycine decarboxylase complex is not essential for the cyanobacterium Synechocystis sp. strain PCC 6803
Plant Biol.
7
15-22
2005
Synechocystis sp., Synechocystis sp. PCC 6803
Manually annotated by BRENDA team
Eisenhut, M.; Kahlon, S.; Hasse, D.; Ewald, R.; Lieman-Hurwitz, J.; Ogawa, T.; Ruth, W.; Bauwe, H.; Kaplan, A.; Hagemann, M.
The plant-like C2 glycolate cycle and the bacterial-like glycerate pathway cooperate in phosphoglycolate metabolism in cyanobacteria
Plant Physiol.
142
333-342
2006
Synechocystis sp., Synechocystis sp. PCC 6803
Manually annotated by BRENDA team
Hasse, D.; Mikkat, S.; Thrun, H.A.; Hagemann, M.; Bauwe, H.
Properties of recombinant glycine decarboxylase P- and H-protein subunits from the cyanobacterium Synechocystis sp. strain PCC 6803
FEBS Lett.
581
1297-1301
2007
Synechocystis sp.
Manually annotated by BRENDA team
Rajinikanth, M.; Harding, S.A.; Tsai, C.J.
The glycine decarboxylase complex multienzyme family in Populus
J. Exp. Bot.
58
1761-1770
2007
Populus tremuloides (A9PL02)
Manually annotated by BRENDA team
Parys, E.; Jastrzebski, H.
Mitochondria from leaf mesophyll cells of C(4) plants are deficient in the H protein of glycine decarboxylase complex
J. Plant Physiol.
165
1061-1069
2008
Zea mays
Manually annotated by BRENDA team
Engel, N.; van den Daele, K.; Kolukisaoglu, U.; Morgenthal, K.; Weckwerth, W.; Paernik, T.; Keerberg, O.; Bauwe, H.
Deletion of glycine decarboxylase in Arabidopsis is lethal under nonphotorespiratory conditions
Plant Physiol.
144
1328-1335
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Engelmann, S.; Wiludda, C.; Burscheidt, J.; Gowik, U.; Schlue, U.; Koczor, M.; Streubel, M.; Cossu, R.; Bauwe, H.; Westhoff, P.
The gene for the P-subunit of glycine decarboxylase from the C4 species Flaveria trinervia: analysis of transcriptional control in transgenic Flaveria bidentis (C4) and Arabidopsis (C3)
Plant Physiol.
146
1773-1785
2008
Flaveria trinervia
Manually annotated by BRENDA team
Hasse, D.; Mikkat, S.; Hagemann, M.; Bauwe, H.
Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase
FEBS J.
276
6985-6991
2009
Flaveria trinervia
Manually annotated by BRENDA team
Kawaguchi, H.; Okamoto, S.; Sikdar, D.; Kume, A.; Li, F.; Mohafez, O.M.; Shehata, M.H.; Hiraga, K.
Genomic organization of regions that regulate chicken glycine decarboxylase gene transcription: physiological and pathological implications
Gene
432
7-18
2009
Gallus gallus (P15505), Gallus gallus
Manually annotated by BRENDA team
Kikuchi, G.; Motokawa, Y.; Yoshida, T.; Hiraga, K.
Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia
Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
84
246-263
2008
Gallus gallus, Gottschalkia acidurici, Escherichia coli, Peptoclostridium acidaminophilum, Thermus thermophilus, Homo sapiens, Pisum sativum
Manually annotated by BRENDA team
Hasse, D.; Hagemann, M.; Andersson, I.; Bauwe, H.
Crystallization and preliminary X-ray diffraction analyses of the homodimeric glycine decarboxylase (P-protein) from the cyanobacterium Synechocystis sp. PCC 6803
Acta Crystallogr. Sect. F
66
187-191
2010
Synechocystis sp. (P74416), Synechocystis sp.
Manually annotated by BRENDA team
Palmieri, M.C.; Lindermayr, C.; Bauwe, H.; Steinhauser, C.; Durner, J.
Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation
Plant Physiol.
152
1514-1528
2010
Arabidopsis thaliana (P25855)
Manually annotated by BRENDA team
Okamura-Ikeda, K.; Hosaka, H.; Maita, N.; Fujiwara, K.; Yoshizawa, A.C.; Nakagawa, A.; Taniguchi, H.
Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism
J. Biol. Chem.
285
18684-18692
2010
Escherichia coli
Manually annotated by BRENDA team
Zay, A.; Choy, F.Y.; Patrick, C.; Sinclair, G.
Glycine cleavage enzyme complex: molecular cloning and expression of the H-protein cDNA from cultured human skin fibroblasts
Biochem. Cell Biol.
89
299-307
2011
Homo sapiens (P23434), Homo sapiens
Manually annotated by BRENDA team
Dominy, J.; Vazquez, F.; Puigserver, P.
Glycine decarboxylase cleaves a malignant metabolic path to promote tumor initiation
Cancer Cell
21
143-145
2012
Mus musculus
Manually annotated by BRENDA team
Timm, S.; Florian, A.; Arrivault, S.; Stitt, M.; Fernie, A.R.; Bauwe, H.
Glycine decarboxylase controls photosynthesis and plant growth
FEBS Lett.
586
3692-3697
2012
Arabidopsis thaliana
Manually annotated by BRENDA team
Zhang, C.; Park, I.; Xu, F.; Li, M.; Lim, Y.; Meng, J.
Transcriptionally and phylogenetically analyzing the P protein gene of glycine decarboxylase for understanding the evolution of C3-C4 species in Brassicaceae
Hortic. Environ. Biotechnol.
52
427-434
2011
Brassica napus
-
Manually annotated by BRENDA team
Go, M.K.; Zhang, W.C.; Lim, B.; Yew, W.S.
Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis
Biochemistry
53
947-956
2014
Homo sapiens (P23378), Homo sapiens
Manually annotated by BRENDA team
Azize, N.A.; Ngah, W.Z.; Othman, Z.; Md Desa, N.; Chin, C.B.; Md Yunus, Z.; Mohan, A.; Hean, T.S.; Syed Zakaria, S.Z.; Lock-Hock, N.
Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy
J. Hum. Genet.
59
593-597
2014
Homo sapiens (P23378), Homo sapiens
Manually annotated by BRENDA team
Varadarajan, N.M.; Sundaram, B.; Subramani, P.A.; Kalappa, D.M.; Ghosh, S.K.; Nagaraj, V.A.
Plasmodium berghei glycine cleavage system T-protein is non-essential for parasite survival in vertebrate and invertebrate hosts
Mol. Biochem. Parasitol.
197
50-55
2014
no activity in Plasmodium berghei
Manually annotated by BRENDA team
Simmons, R.M.; McKnight, S.M.; Edwards, A.K.; Wu, G.; Satterfield, M.C.
Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats
Amino Acids
52
1413-1423
2020
Rattus norvegicus (D4A5Q9)
Manually annotated by BRENDA team
Wei, H.Y.; Feng, R.; Shao, H.; Feng, B.; Liu, H.Q.; Men, J.L.; Zou, W.
Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression
Mol. Med. Rep.
18
2293-2299
2018
Homo sapiens (P23378)
Manually annotated by BRENDA team
Zhuang, H.; Li, Q.; Zhang, X.; Ma, X.; Wang, Z.; Liu, Y.; Yi, X.; Chen, R.; Han, F.; Zhang, N.; Li, Y.
Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells
Free Radic. Biol. Med.
120
1-12
2018
Homo sapiens (P23378)
Manually annotated by BRENDA team
Kang, P.J.; Zheng, J.; Lee, G.; Son, D.; Kim, I.Y.; Song, G.; Park, G.; You, S.
Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control
Metab. Eng.
53
35-47
2019
Homo sapiens (P23378)
Manually annotated by BRENDA team
Liu, R.; Zeng, L.W.; Gong, R.; Yuan, F.; Shu, H.B.; Li, S.
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
Nat. Commun.
12
4227
2021
Homo sapiens (P23378), Homo sapiens
Manually annotated by BRENDA team
Kose, E.; Yis, U.; Hiz, S.; Arslan, N.
A novel mutation in the glycine decarboxylase gene in patient with non-ketotic hyperglycinemia
Neurosciences (Riyadh)
22
131-133
2017
Homo sapiens (P23378), Homo sapiens
Manually annotated by BRENDA team
Alptekin, A.; Ye, B.; Yu, Y.; Poole, C.J.; van Riggelen, J.; Zha, Y.; Ding, H.F.
Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity
Oncogene
38
7504-7520
2019
Homo sapiens (P23378)
Manually annotated by BRENDA team
Berezowska, S.; Galvan, J.A.; Langer, R.; Bubendorf, L.; Savic, S.; Gugger, M.; Schmid, R.A.; Marti, T.M.
Glycine decarboxylase and HIF-1alpha expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer
Virchows Arch.
470
323-330
2017
Homo sapiens (P23378), Homo sapiens
Manually annotated by BRENDA team