1.4.99.5: glycine dehydrogenase (cyanide-forming)
This is an abbreviated version!
For detailed information about glycine dehydrogenase (cyanide-forming), go to the full flat file.
Word Map on EC 1.4.99.5
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1.4.99.5
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aeruginosa
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hcnabc
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fluorescens
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anr
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gaca
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fnr-like
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rhizosphere
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plant-beneficial
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pathosystems
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cyanogenesis
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oxysporum
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two-component
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2,4-diacetylphloroglucinol
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till
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pseudomonads
- 1.4.99.5
- aeruginosa
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hcnabc
- fluorescens
- anr
- gaca
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fnr-like
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rhizosphere
-
plant-beneficial
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pathosystems
-
cyanogenesis
- oxysporum
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two-component
- 2,4-diacetylphloroglucinol
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till
- pseudomonads
Reaction
Synonyms
cyanogenic enzyme system, HCA, HCN synthase, HcnC, HCS, hydrogen cyanide synthase, synthase, hydrogen cyanide (9Cl)
ECTree
1.4.99.5 glycine dehydrogenase (cyanide-forming)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.4.99.5 - glycine dehydrogenase (cyanide-forming)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
glycine + 2,2'-di-(p-nitrophenyl-5,5')-(diphenyl)-3,3'-(3,3'-dimethoxy-4,4'-diphenylene) ditetrazolium chloride
HCN + ?
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NBT
-
-
?
glycine + 2-(p-iodophenyl)-3-(p-nitrophenyl)-5-phenyl-tetrazolium chloride
HCN + CO2 + ?
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INT
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-
?
glycine + FAD
HCN + CO2 + FADH2
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glycine is decarboxylated to HCN by the enzyme HCN synthase, the product of the hcnABC synthase gene cluster
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-
?
glycine + 2,6-dichlorophenol-indophenol
HCN + CO2 + ?
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DCIP
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-
?
glycine + O2
HCN + CO2 + 2 H2O
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-
-
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?
glycine + O2
HCN + CO2 + 2 H2O
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-
-
-
?
glycine + O2
HCN + CO2 + H2O
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-
-
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?
glycine + O2
HCN + CO2 + H2O
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dissolved oxygen regulates the synthesis of the cyanogenic enzyme system
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?
glycine + O2
HCN + CO2 + H2O
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dissolved oxygen regulates the synthesis of the cyanogenic enzyme system
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-
?
glycine + phenazine methosulfate
HCN + CO2 + ?
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PMS provided greatest activity, oxygen allows only a limited response
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?
glycine + phenazine methosulfate
HCN + CO2 + ?
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PMS provided greatest activity, oxygen allows only a limited response
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-
?
additional information
?
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sodium nitrate, sodium nitrite, NAD+, NADP+, FAD and FMN fail as electron acceptors to support cyanide biosynthesis
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-
?
additional information
?
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cyanide produced by the enzyme is involved in virulence of the organism. Drosophila melanogaster exposed to cyanogenic Pseudomonas aeruginosa strains have high cyanide and low ATP concentrations in body extracts, and treatment with a cyanide antidote equalized survival of flies injected with cyanogenic and noncyanogenic strains. Strain PAO1 with a mutation in the hydrogen cyanide synthase gene cluster is much less toxic to flies than the parental cyanogenic strain or 2 knock-in strains, overview
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?
additional information
?
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sodium nitrate, sodium nitrite, NAD+, NADP+, FAD and FMN fail as electron acceptors to support cyanide biosynthesis
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?
