1.4.99.B4: cis-4-hydroxy-D-proline dehydrogenase

This is an abbreviated version!
For detailed information about cis-4-hydroxy-D-proline dehydrogenase, go to the full flat file.

Reaction

Synonyms

AbLhpBEF, C4DHyp dehydrogenase, HYPDH, LhpBEF, SM_b20267

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.99 With unknown physiological acceptors

                1.4.99.B4 cis-4-hydroxy-D-proline dehydrogenase

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Results	in table
1	AA Sequence
1	Application
1	Cloned(Commentary)
2	Cofactor
1	General Information
8	kcat/KM [mM/s]
11	KM Value [mM]
2	Natural Substrates/ Products (Substrates)
2	Organism
2	pH Optimum
1	Purification (Commentary)
2	Reference
10	Specific Activity [micromol/min/mg]
9	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
8	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 1.4.99.B4 - cis-4-hydroxy-D-proline dehydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

cis-4-hydroxy-D-proline + acceptor

(4R)-DELTA1-pyrroline-4-hydroxy-2-carboxylate + reduced acceptor

3 entries

D-methionine + acceptor + acceptor

?

Sinorhizobium meliloti

Q92WS2

-

764324

-

-

?

D-pipecolate + acceptor + acceptor

?

Sinorhizobium meliloti

Q92WS2

-

764324

-

-

?

D-proline + acceptor

?

Azospirillum brasilense

S6C8W7; S6CFJ1; S6CLS6

the Vmax/Km value of the enzyme for cis-4-hydroxy-D-proline is about 124fold and about 736fold higher than the Vmax/Km values for trans-4-hydroxy-D-proline and D-proline, respectively. Both AbLhpBEF (heteromer of alpha-, beta- and gamma-subunit) and AbLhpB (catalytic beta-subunit) are strictly specific to cis-4-hydroxy-D-proline

748266

-

-

?

D-proline + acceptor + acceptor

?

Sinorhizobium meliloti

Q92WS2

-

764324

-

-

?

trans-4-hydroxy-D-proline + acceptor

?

2 entries

cis-4-hydroxy-D-proline + acceptor

(4R)-DELTA1-pyrroline-4-hydroxy-2-carboxylate + reduced acceptor

Azospirillum brasilense

S6C8W7; S6CFJ1; S6CLS6

the enzyme is involved in the metabolic pathway of trans-4-hydroxy-L-proline

748266

-

-

?

cis-4-hydroxy-D-proline + acceptor

(4R)-DELTA1-pyrroline-4-hydroxy-2-carboxylate + reduced acceptor

Azospirillum brasilense

S6C8W7; S6CFJ1; S6CLS6

the Vmax/Km value of the enzyme for cis-4-hydroxy-D-proline is about 124fold and about 736fold higher than the Vmax/Km values for trans-4-hydroxy-D-proline and D-proline, respectively. Both AbLhpBEF (heteromer of alpha-, beta- and gamma-subunit) and AbLhpB (catalytic beta-subunit) are strictly specific to cis-4-hydroxy-D-proline

748266

-

-

?

cis-4-hydroxy-D-proline + acceptor

(4R)-DELTA1-pyrroline-4-hydroxy-2-carboxylate + reduced acceptor

Sinorhizobium meliloti

Q92WS2

-

764324

-

-

?

trans-4-hydroxy-D-proline + acceptor

?

Azospirillum brasilense

S6C8W7; S6CFJ1; S6CLS6

the Vmax/Km value of the enzyme for cis-4-hydroxy-D-proline is about 124fold and about 736fold higher than the Vmax/Km values for trans-4-hydroxy-D-proline and D-proline, respectively. Both AbLhpBEF (heteromer of alpha-, beta- and gamma-subunit) and AbLhpB (catalytic beta-subunit) are strictly specific to cis-4-hydroxy-D-proline

748266

-

-

?

trans-4-hydroxy-D-proline + acceptor

?

Sinorhizobium meliloti

Q92WS2

-

764324

-

-

?