Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.5.1.1: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], go to the full flat file.

Word Map on EC 1.5.1.1

Reaction

L-pipecolate
+
NAD(P)+
=
1-piperideine-2-carboxylate
+
NAD(P)H
+
H+

Synonyms

CphpI, CRYM, CtBP, cytosolic thyroid hormone binding protein, DELTA1-piperideine-2-carboxylate reductase, DELTA1-Pyr2C reductase, DELTA1-pyrroline-2-carboxylate reductase, ketimine reductase, KR/CRYM/CTBP, L-proline:NAD(P)+ 2-oxidoreductase, lhpI, More, mu-crystallin, NAD(P)H-dependent DELTA1-pyrroline-2-carboxylate reductase, P2C reductase, P2C/Pyr2C reductase, P2C/Pyr2C/ketimine reductase, PLP-dependent amino acid gamma-substitution enzyme, PYCR2, Pyr2C reductase, Pyr2C/Pip2C reductase, pyrroline-2-carboxylate reductase, reductase, pyrroline-2-carboxylate, THBP, thyroid hormone binding protein

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

Reference

Reference on EC 1.5.1.1 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garweg, G.; von Rehren, D.; Hintze, U.
L-Pipecolate formation in the mammalian brain. Regional distribution of DELTA1-pyrroline-2-carboxylate reductase activity
J. Neurochem.
35
616-621
1980
Canis lupus familiaris, Cercocebus sp., Mus musculus
Manually annotated by BRENDA team
Meister, A.; Radhakrishnan, A.N.; Buckley, S.D.
Enzymatic synthesis of L-pipecolic acid and L-proline
J. Biol. Chem.
229
789-800
1957
Klebsiella aerogenes, Neurospora crassa, Vigna radiata var. radiata, Pisum sativum, Rattus norvegicus
Manually annotated by BRENDA team
Muramatsu, H.; Mihara, H.; Kakutani, R.; Yasuda, M.; Ueda, M.; Kurihara, T.; Esaki, N.
The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline
J. Biol. Chem.
280
5329-5335
2005
Pseudomonas putida
Manually annotated by BRENDA team
Goto, M.; Muramatsu, H.; Mihara, H.; Kurihara, T.; Esaki, N.; Omi, R.; Miyahara, I.; Hirotsu, K.
Crystal structures of DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction
J. Biol. Chem.
280
40875-40884
2005
Pseudomonas syringae (Q4U331)
Manually annotated by BRENDA team
Hallen, A.; Jamie, J.F.; Cooper, A.J.
Lysine metabolism in mammalian brain an update on the importance of recent discoveries
Amino Acids
45
1249-1272
2013
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Watanabe, S.; Tanimoto, Y.; Yamauchi, S.; Tozawa, Y.; Sawayama, S.; Watanabe, Y.
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and DELTA1-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria
FEBS Open Bio
4
240-250
2014
Colwellia psychrerythraea (Q485R8), Azospirillum brasilense (V5YW53), Azospirillum brasilense
Manually annotated by BRENDA team
Hallen, A.; Jamie, J.; Cooper, A.
Imine reductases A comparison of glutamate dehydrogenase to ketimine reductases in the brain
Neurochem. Res.
39
527-541
2014
Rattus norvegicus
-
Manually annotated by BRENDA team
Hallen, A.; Cooper, A.J.
Reciprocal control of thyroid binding and the pipecolate pathway in the brain
Neurochem. Res.
42
217-243
2017
Homo sapiens (Q14894), Homo sapiens
Manually annotated by BRENDA team