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1.5.1.11: D-octopine dehydrogenase

This is an abbreviated version!
For detailed information about D-octopine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.1.11

Reaction

N2-(D-1-carboxyethyl)-L-arginine
+
NAD+
 +
H2O
=
L-arginine
 +
pyruvate
 +
NADH
 +
H+

Synonyms

OCS, D-Octopine synthase, Octopine dehydrogenase, Dehydrogenase, octopine, Octopine:NAD oxidoreductase, ODH, Octopine synthase, N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase, OcDH, N2-(D-1-carboxyethyl)-L-arginine:NAD+-oxidoreductase, flavin-containing opine dehydrogenase, pTi_008

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.11 D-octopine dehydrogenase

Engineering

Engineering on EC 1.5.1.11 - D-octopine dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C148S
the mutant shows reduced activity and is only slightly inhibited by 5,5'-dithiobis(2-nitrobenzoic acid) and p-chloromercuribenzoate
C148A
the mutant shows reduced activity
Q118A
reduced activity
D329A
the mutation results in strong increases in Km and decreases in kcat values for pyruvate and L-arginine, but has little effect on the Km and kcat values for NADH
H212A
the mutation results in strong increases in Km and decreases in kcat values for pyruvate and L-arginine, but has little effect on the Km and kcat values for NADH
R324A
the mutation results in strong increases in Km and decreases in kcat values for pyruvate and L-arginine, but has little effect on the Km and kcat values for NADH
Q118D
reduced activity