Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.5.1.11: D-octopine dehydrogenase

This is an abbreviated version!
For detailed information about D-octopine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.1.11

Reaction

N2-(D-1-carboxyethyl)-L-arginine
+
NAD+
 +
H2O
=
L-arginine
 +
pyruvate
 +
NADH
 +
H+

Synonyms

D-Octopine synthase, Dehydrogenase, octopine, flavin-containing opine dehydrogenase, N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase, N2-(D-1-carboxyethyl)-L-arginine:NAD+-oxidoreductase, OcDH, OCS, Octopine dehydrogenase, Octopine synthase, Octopine:NAD oxidoreductase, ODH, pTi_008

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.11 D-octopine dehydrogenase

Engineering

Engineering on EC 1.5.1.11 - D-octopine dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C148A
the mutant shows reduced activity
C148S
the mutant shows reduced activity and is only slightly inhibited by 5,5'-dithiobis(2-nitrobenzoic acid) and p-chloromercuribenzoate
D329A
the mutation results in strong increases in Km and decreases in kcat values for pyruvate and L-arginine, but has little effect on the Km and kcat values for NADH
H212A
the mutation results in strong increases in Km and decreases in kcat values for pyruvate and L-arginine, but has little effect on the Km and kcat values for NADH
Q118A
reduced activity
Q118D
reduced activity
R324A
the mutation results in strong increases in Km and decreases in kcat values for pyruvate and L-arginine, but has little effect on the Km and kcat values for NADH