1.5.1.2: pyrroline-5-carboxylate reductase

This is an abbreviated version!
For detailed information about pyrroline-5-carboxylate reductase, go to the full flat file.

Word Map on EC 1.5.1.2

Reaction

L-proline
+
NAD(P)+
=
1-pyrroline-5-carboxylate
+
NAD(P)H
+
H+

Synonyms

1-pyrroline-5-carboxylate reductase, DELTA1-pyrroline-5-carboxylate reductase, L-proline oxidase, L-proline-NAD(P)+ 5-oxidoreductase, L-proline:NAD(P)+ 5-oxidoreductase, MTR_7g090160, NADPH-L-DELTA'-pyrroline carboxylic acid reductase, P5C reductase, P5CDH, P5CR, PO, POX, proline oxidase, Pycr1, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate reductase, reductase, pyrroline-5-carboxylate

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.2 pyrroline-5-carboxylate reductase

Activating Compound

Activating Compound on EC 1.5.1.2 - pyrroline-5-carboxylate reductase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cl-
progressive stimulation by chloride ions from 20-200 mM, inhibitory above. At 100 mM, 1.8fold stimulation in presence of NADH
EDTA
-
stimulation of undialyzed enzyme at 30 mM
NaCl
-
a significant increase in the P5C reductase activity is observed with increasing severity of NaCl stress (0-200 mM)
P53
-
POX is a p53-induced gene
putrescine
-
11% activation at 5 mM
spermidine
-
10% activation at 1.2 mM
spermine
-
13% activation at 1.2 mM
troglitazone
-
is found to activate the POX promoter in colon cancer cells