1.5.1.2: pyrroline-5-carboxylate reductase

This is an abbreviated version!
For detailed information about pyrroline-5-carboxylate reductase, go to the full flat file.

Word Map on EC 1.5.1.2

Reaction

L-proline
+
NAD(P)+
=
1-pyrroline-5-carboxylate
+
NAD(P)H
+
H+

Synonyms

1-pyrroline-5-carboxylate reductase, DELTA1-pyrroline-5-carboxylate reductase, L-proline oxidase, L-proline-NAD(P)+ 5-oxidoreductase, L-proline:NAD(P)+ 5-oxidoreductase, MTR_7g090160, NADPH-L-DELTA'-pyrroline carboxylic acid reductase, P5C reductase, P5CDH, P5CR, PO, POX, proline oxidase, Pycr1, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate reductase, reductase, pyrroline-5-carboxylate

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.2 pyrroline-5-carboxylate reductase

IC50 Value

IC50 Value on EC 1.5.1.2 - pyrroline-5-carboxylate reductase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00078
([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid)
Streptococcus pyogenes
-
pH 7.5-8.0, at 37°C
1.187
2,3-dichlorophenylhydroxymethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.488
2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.431
2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
1.639
2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.763
2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.463
2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.082
2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
1.914
2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.386
2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.488
2-(4-benzylphenylamino)ethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
2.071
2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.413
3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.054
3,5-dibromophenylaminomethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.719
3,5-difluorophenylaminomethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
1.409
3,5-dimethylphenylhydroxymethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.547
3-carbamoylphenylaminomethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
1.618
3-chlorophenylaminomethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.852
4-benzylphenylaminomethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.325
4-benzylphenylhydroxymethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.684
5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
0.485 - 0.704
Cl-
29
EDTA
Streptococcus pyogenes
-
at pH 7.5 and 37°C
1.887
indan-5-ylaminomethylenebisphosphonic acid
Arabidopsis thaliana
-
in 100 mM HEPES-KOH buffer, pH 7.75, at 35°C
200
KCl
Arabidopsis thaliana
F4K884
cofactor NADH, pH 7.8, 35°C
200
NaCl
Arabidopsis thaliana
F4K884
cofactor NADH, pH 7.8, 35°C
0.032 - 1.44
NADP+
0.00087 - 0.335
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.012
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Streptococcus pyogenes
-
pH 7.5-8.0, at 37°C
0.0027
[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Streptococcus pyogenes
-
pH 7.5-8.0, at 37°C
0.00088 - 0.45
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.00039
[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
Streptococcus pyogenes
-
pH 7.5-8.0, at 37°C
0.00022
[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid)
Streptococcus pyogenes
-
pH 7.5-8.0, at 37°C
0.00022 - 0.134
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0256 - 1.245
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
0.0009
[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
Streptococcus pyogenes
-
pH 7.5-8.0, at 37°C
0.00041
[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid)
Streptococcus pyogenes
-
pH 7.5-8.0, at 37°C
0.0014 - 0.97
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)