1.5.1.2: pyrroline-5-carboxylate reductase

This is an abbreviated version!
For detailed information about pyrroline-5-carboxylate reductase, go to the full flat file.

Word Map on EC 1.5.1.2

Reaction

L-proline
+
NAD(P)+
=
1-pyrroline-5-carboxylate
+
NAD(P)H
+
H+

Synonyms

1-pyrroline-5-carboxylate reductase, DELTA1-pyrroline-5-carboxylate reductase, L-proline oxidase, L-proline-NAD(P)+ 5-oxidoreductase, L-proline:NAD(P)+ 5-oxidoreductase, MTR_7g090160, NADPH-L-DELTA'-pyrroline carboxylic acid reductase, P5C reductase, P5CDH, P5CR, PO, POX, proline oxidase, Pycr1, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate reductase, reductase, pyrroline-5-carboxylate

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.2 pyrroline-5-carboxylate reductase

Inhibitors

Inhibitors on EC 1.5.1.2 - pyrroline-5-carboxylate reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid)
-
71.2% inhibition at 0.2 mM
2,3-dichlorophenylhydroxymethylenebisphosphonic acid
-
-
2-(2,3-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
-
2-(2,3-dichlorophenylamino)ethylidenebisphosphonic acid
-
-
2-(2,6-dichlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
-
2-(2,6-dichlorophenylamino)ethylidenebisphosphonic acid
-
-
2-(3,5-di(trifluoromethyl)phenylamino)ethylidenebisphosphonic acid
-
-
2-(3,5-dichlorophenylamino)ethylidenebisphosphonic acid
-
-
2-(3,5-dimethylphenyl)-1-hydroxyethylidenebisphosphonic acid
-
-
2-(3,5-dimethylphenylamino)ethylidenebisphosphonic acid
-
-
2-(4-benzylphenylamino)ethylidenebisphosphonic acid
-
-
2-(4-chlorophenyl)-1-hydroxyethylidenebisphosphonic acid
-
-
3,5-di(trifluoromethyl)phenylaminomethylenebisphosphonic acid
-
-
3,5-dibromophenylaminomethylenebisphosphonic acid
-
-
3,5-difluorophenylaminomethylenebisphosphonic acid
-
-
3,5-dimethylphenylhydroxymethylenebisphosphonic acid
-
-
3-acetylpyridine analogue of NAD+
-
95% inhibition at 2 mM
3-carbamoylphenylaminomethylenebisphosphonic acid
-
-
3-chlorophenylaminomethylenebisphosphonic acid
-
-
4-benzylphenylaminomethylenebisphosphonic acid
-
-
4-benzylphenylhydroxymethylenebisphosphonic acid
-
-
5,5'-dithiobis(2-nitrobenzoate)
-
90% inhibition at 0.012 mM
5,6,7,8-tetrahydro-2-naphthylaminomethylenebisphosphonic acid
-
-
Cl-
progressive stimulation from 20-200 mM, inhibitory above
CTP
-
91% inactivation at 1 mM reversible with Mg2+
cysteine
-
77% inactivation at 10 mM
D-allohydroxyproline
-
competitive inhibition
DL-pipecolic acid
-
65% inhibition at 10mM
GTP
-
100% inactivation at 10 mM, reversible with Mg2+
hydroxylamine
-
-
imidazole
-
-
indan-5-ylaminomethylenebisphosphonic acid
-
-
iodoacetamide
-
complete inactivation at 1 mM
iodoacetate
-
10% inactivation at 1 mM
L-2-acetidine-4-carboxylic acid
-
50% inactivation at 2 mM
L-hydroxyproline
-
competitive inhibition
L-proline
Mn2+
-
-
N-ethylmaleimide
-
90% inhibition at 0.02 mM, inhibition can be prevented by NADH
NADP+
NADPH
-
above 0.13 mM
NaHSO3
-
88% inactivation at 1 mM
NH2OH
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
90% inhibition at 0.008 mM, inhibition can be prevented by addition of excess dithiothreitol
phosphate
-
-
proline
pyrroline-5-carboxylate
Sodium bisulfite
-
-
stearoyl-CoA
-
competitive inhibitor of P5CR NAD(P)H-dependent thioproline dehydrogenase activity
thiazolidine-4-carboxylic acid
thio-NAD+
-
65% inactivation at 0.2 mM
thio-NADP+
-
65% inactivation at 0.2 mM
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
52% inhibition at 0.2 mM
[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
63.9% inhibition at 0.2 mM
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
92.5% inhibition at 0.2 mM
[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid)
-
98.4% inhibition at 0.2 mM
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
-
71.2% inhibition at 0.2 mM
[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid)
-
94.5% inhibition at 0.2 mM
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
additional information
-