1.5.1.2: pyrroline-5-carboxylate reductase

This is an abbreviated version!
For detailed information about pyrroline-5-carboxylate reductase, go to the full flat file.

Word Map on EC 1.5.1.2

Reaction

L-proline
+
NAD(P)+
=
1-pyrroline-5-carboxylate
+
NAD(P)H
+
H+

Synonyms

1-pyrroline-5-carboxylate reductase, DELTA1-pyrroline-5-carboxylate reductase, L-proline oxidase, L-proline-NAD(P)+ 5-oxidoreductase, L-proline:NAD(P)+ 5-oxidoreductase, MTR_7g090160, NADPH-L-DELTA'-pyrroline carboxylic acid reductase, P5C reductase, P5CDH, P5CR, PO, POX, proline oxidase, Pycr1, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylate reductase, reductase, pyrroline-5-carboxylate

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.2 pyrroline-5-carboxylate reductase

Substrates Products

Substrates Products on EC 1.5.1.2 - pyrroline-5-carboxylate reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-pyrroline-3-hydroxy-5-carboxylate + NAD(P)H
L-hydroxyproline + NAD(P)+
show the reaction diagram
-
-
-
ir
1-pyrroline-5-carboxylate + NAD(P)H
L-proline + NAD(P)+
show the reaction diagram
1-pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
show the reaction diagram
1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
show the reaction diagram
1-pyrroline-5-carboxylate + NADPH + H+
L-proline + NADP+
show the reaction diagram
3,4-dehydro-DL-proline + NADPH
?
show the reaction diagram
-
-
-
-
?
3,4-dehydro-L-proline + NAD+
?
show the reaction diagram
activity assay
-
-
?
DELTA1-piperideine-6-carboxylate + NADPH
L-pipecolic acid + NADP+
show the reaction diagram
-
-
-
ir
DELTA1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
show the reaction diagram
-
-
-
r
L-Pro + NAD(P)+
1-pyrroline-5-carboxylate + NAD(P)H
show the reaction diagram
-
the enzyme plays a role as a downstream effector in p53-mediated apoptosis of renal carcinoma cells
-
-
-
L-Pro + NAD+
1-pyrroline-5-carboxylate + NADH
show the reaction diagram
L-Pro + NADP+
1-pyrroline-5-carboxylate + NADPH
show the reaction diagram
-
-
-
-
?
L-proline + NAD(P)+
1-pyrroline-5-carboxylate + NAD(P)H
show the reaction diagram
L-proline + NAD(P)+
1-pyrroline-5-carboxylate + NAD(P)H + H+
show the reaction diagram
L-proline + NADP+
1-pyrroline-5-carboxylate + NADPH + H+
show the reaction diagram
L-proline benzyl ester + NAD+
L-pyrroline-5-carboxy benzyl ester + NADH
show the reaction diagram
-
24% of activity with proline
-
-
?
L-proline methyl ester + NAD+
1-pyrroline-5-carboxy methyl ester + NADH
show the reaction diagram
-
16% of activity with proline
-
-
?
L-proline t-butyl ester + NAD+
1-pyrroline-5-carboxy tert-butylester + NADH
show the reaction diagram
-
10% of activity with proline
-
-
?
L-thioproline + NAD(P)+
1-pyrroline-3-thio-5-carboxylate + NAD(P)H
show the reaction diagram
piperideine-6-carboxylate + NADH + H+
L-pipecolic acid + NAD+
show the reaction diagram
-
-
L-pipecolic acid is the sole product
-
ir
piperideine-6-carboxylate + NADPH + H+
L-pipecolic acid + NADP+
show the reaction diagram
-
-
L-pipecolic acid is the sole product
-
ir
pyrroline-5-carboxylate + NAD(P)H + H+
L-proline + NAD(P)+
show the reaction diagram
additional information
?
-
-
not: D-proline, L-hydroxyproline, L-azatidine-2-carboxylate, no other amino acids
-
-
-