1.5.1.21: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

This is an abbreviated version!
For detailed information about 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), go to the full flat file.

Word Map on EC 1.5.1.21

Reaction

L-pipecolate
+
NADP+
=
1-piperideine-2-carboxylate
+
NADPH
+
H+

Synonyms

1,2-didehydropipecolate reductase, 1,2-didehydropipecolic reductase, CRYM, DELTA1-piperideine-2-carboxylate reductase, DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, DpkA, EC 1.5.1.14, ketimine reductase, L-pipecolate:NADP+ 2-oxidoreductase, lhpD, mu-crystallin, NAD(P)H-dependent DELTA1-pyrroline-2-carboxylate reductase, P2C reductase, P2C/Pyr2C reductase, PaLhpD, Pip2CR, Pyr2C reductase, Pyr2C/Pip2C reductase, reductase, DELTA 1-piperideine-2-carboxylate

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

KM Value

KM Value on EC 1.5.1.21 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.57
1-piperideine-2-carboxylate
purified recombinant His-tagged enzyme, with NADPH, pH 7.0, 30C
0.835
1-pyrroline-(4R)-hydroxy-2-carboxylate
purified recombinant His-tagged enzyme, with NADPH, pH 7.0, 30C
0.447
1-pyrroline-2-carboxylate
purified recombinant His-tagged enzyme, with NADPH, pH 7.0, 30C
0.23 - 1.6
DELTA1-piperideine-2-carboxylate
0.4
DELTA1-Pyrroline-5-carboxylate
-
-
0.28
diglutamate
-
-
34.8
L-pipecolate
purified recombinant His-tagged enzyme, with NADPH, pH 7.0, 30C
18.5
L-proline
purified recombinant His-tagged enzyme, with NADPH, pH 7.0, 30C
0.034 - 0.14
NADP+
0.034 - 0.14
NADPH
132
trans-3-hydroxy-L-proline
purified recombinant His-tagged enzyme, with NADPH, pH 7.0, 30C
additional information
additional information
-