1.5.1.21: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

This is an abbreviated version!
For detailed information about 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), go to the full flat file.

Word Map on EC 1.5.1.21

Reaction

L-pipecolate
+
NADP+
=
1-piperideine-2-carboxylate
+
NADPH
+
H+

Synonyms

1,2-didehydropipecolate reductase, 1,2-didehydropipecolic reductase, CRYM, DELTA1-piperideine-2-carboxylate reductase, DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, DpkA, EC 1.5.1.14, ketimine reductase, L-pipecolate:NADP+ 2-oxidoreductase, lhpD, mu-crystallin, NAD(P)H-dependent DELTA1-pyrroline-2-carboxylate reductase, P2C reductase, P2C/Pyr2C reductase, PaLhpD, Pip2CR, Pyr2C reductase, Pyr2C/Pip2C reductase, reductase, DELTA 1-piperideine-2-carboxylate

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

Reference

Reference on EC 1.5.1.21 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chang, Y.F.; Adams, E.
D-lysine catabolic pathway in Pseudomonas putida: interrelations with L-lysine catabolism
J. Bacteriol.
117
753-764
1974
Pseudomonas putida
Manually annotated by BRENDA team
Payton, C.W.; Chang, Y.F.
DELTA1-Piperideine-2-carboxylate reductase of Pseudomonas putida
J. Bacteriol.
149
864-871
1982
Pseudomonas putida
Manually annotated by BRENDA team
Cao, X.; Kolonay, J.Jr.; Saxton, K.A.; Hartline, R.A.
The OCT plasmid encodes D-lysine membrane transport and catabolic enzymes in Pseudomonas putida
Plasmid
30
83-89
1993
Pseudomonas putida
Manually annotated by BRENDA team
Muramatsu, H.; Mihara, H.; Kakutani, R.; Yasuda, M.; Ueda, M.; Kurihara, T.; Esaki, N.
The putative malate/lactate dehydrogenase from Pseudomonas putida is an NADPH-dependent DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase involved in the catabolism of D-lysine and D-proline
J. Biol. Chem.
280
5329-5335
2005
Pseudomonas putida (Q5FB93), Pseudomonas putida, Pseudomonas putida ATCC 12633 (Q5FB93)
Manually annotated by BRENDA team
Muramatsu, H.; Mihara, H.; Yasuda, M.; Ueda, M.; Kurihara, T.; Esaki, N.
Enzymatic synthesis of L-pipecolic acid by DELTA1-piperideine-2-carboxylate reductase from Pseudomonas putida
Biosci. Biotechnol. Biochem.
70
2296-2298
2006
Pseudomonas putida
Manually annotated by BRENDA team
Goto, M.; Muramatsu, H.; Mihara, H.; Kurihara, T.; Esaki, N.; Omi, R.; Miyahara, I.; Hirotsu, K.
Crystal structures of DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase belonging to a new family of NAD(P)H-dependent oxidoreductases: conformational change, substrate recognition, and stereochemistry of the reaction
J. Biol. Chem.
280
40875-40884
2005
Pseudomonas syringae (Q4U331)
Manually annotated by BRENDA team
Umair, S.; Bland, R.J.; Simpson, H.V.
Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta
Exp. Parasitol.
131
101-106
2012
Haemonchus contortus, Teladorsagia circumcincta
Manually annotated by BRENDA team
Hallen, A.; Jamie, J.F.; Cooper, A.J.
Lysine metabolism in mammalian brain an update on the importance of recent discoveries
Amino Acids
45
1249-1272
2013
Bos taurus, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Watanabe, S.; Tanimoto, Y.; Yamauchi, S.; Tozawa, Y.; Sawayama, S.; Watanabe, Y.
Identification and characterization of trans-3-hydroxy-l-proline dehydratase and DELTA1-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-l-proline metabolism of bacteria
FEBS Open Bio
4
240-250
2014
Pseudomonas aeruginosa (Q9I492)
Manually annotated by BRENDA team
Hallen, A.; Cooper, A.J.
Reciprocal control of thyroid binding and the pipecolate pathway in the brain
Neurochem. Res.
42
217-243
2017
Canis lupus familiaris, Sus scrofa (F1RPC8), Mus musculus (O54983), Homo sapiens (Q14894), Rattus norvegicus (Q9QYU4), Ovis aries (W5PYW4)
Manually annotated by BRENDA team