1.5.1.21: 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

This is an abbreviated version!
For detailed information about 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), go to the full flat file.

Word Map on EC 1.5.1.21

Reaction

L-pipecolate
+
NADP+
=
1-piperideine-2-carboxylate
+
NADPH
+
H+

Synonyms

1,2-didehydropipecolate reductase, 1,2-didehydropipecolic reductase, CRYM, DELTA1-piperideine-2-carboxylate reductase, DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, DpkA, EC 1.5.1.14, ketimine reductase, L-pipecolate:NADP+ 2-oxidoreductase, lhpD, mu-crystallin, NAD(P)H-dependent DELTA1-pyrroline-2-carboxylate reductase, P2C reductase, P2C/Pyr2C reductase, PaLhpD, Pip2CR, Pyr2C reductase, Pyr2C/Pip2C reductase, reductase, DELTA 1-piperideine-2-carboxylate

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

Substrates Products

Substrates Products on EC 1.5.1.21 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-piperideine-2-carboxylate + NADPH + H+
L-pipecolate + NADP+
show the reaction diagram
1-pyrroline-(4R)-hydroxy-2-carboxylate + NADPH + H+
(4R)-hydroxy-L-proline + NADP+
show the reaction diagram
-
-
-
r
1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
show the reaction diagram
alpha-ketobutanoate + methylamine + NADPH
N-methyl-2-aminobutanoate + NADP+ + H2O
show the reaction diagram
10% of the rate with pyruvate
-
-
?
alpha-ketohexanoate + methylamine + NADPH
N-methyl-2-aminohexanoate + NADP+ + H2O
show the reaction diagram
23% of the rate with pyruvate
-
-
?
cis-3-hydroxy-L-proline + NADPH + H+
? + NADP+
show the reaction diagram
low activity
-
-
r
cis-4-hydroxy-L-proline + NADPH + H+
? + NADP+
show the reaction diagram
DELTA1-piperideine 2-carboxylate + NADH + H+
L-pipecolate + NAD+
show the reaction diagram
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
show the reaction diagram
DELTA1-piperideine-2-carboxylate + NADH
L-pipecolate + NAD+
show the reaction diagram
DELTA1-piperideine-2-carboxylate + NADPH
L-pipecolate + NADP+
show the reaction diagram
DELTA1-pyrrolidine 2-carboxylate + NADH + H+
L-pipecolate + NAD+
show the reaction diagram
DELTA1-pyrrolidine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
show the reaction diagram
DELTA1-pyrroline-2-carboxylate + NADPH
L-proline + NADP+
show the reaction diagram
DELTA1-pyrroline-5-carboxylate + NADPH + H+
?
show the reaction diagram
-
very little activity
-
-
r
diglutamate + NADPH + H+
?
show the reaction diagram
-
very little activity
-
-
r
fluoropyruvate + methylamine + NADPH
N-methylfluoroalanine + NADP+ + H2O
show the reaction diagram
14% of the rate with pyruvate
-
-
?
L-pipecolate + NADP+
1-piperideine-2-carboxylate + NADPH + H+
show the reaction diagram
the reaction equilibrium favors the direction toward NADPH-dependent reduction
-
-
r
L-proline + NADP+
1-pyrroline-2-carboxylate + NADPH + H+
show the reaction diagram
the reaction equilibrium favors the direction toward NADPH-dependent reduction
-
-
r
phenylpyruvate + methylamine + NADPH
N-methylphenylalanine + NADP+ + H2O
show the reaction diagram
6.3% of the rate with pyruvate
-
-
?
pyruvate + methylamine
N-methylalanine
show the reaction diagram
-
-
-
?
trans-3-hydroxy-L-proline + NADPH + H+
? + NADP+
show the reaction diagram
moderate activity
-
-
r
additional information
?
-