1.5.1.33: pteridine reductase

This is an abbreviated version!
For detailed information about pteridine reductase, go to the full flat file.

Reaction

Synonyms

Atu1130, EC 1.1.1.253, H region methotrexate resistance protein, LaPTR1, LbPTR1, LdPTR1, LmPTR1, LpPTR1, More, NADPH-dependent short-chain dehydrogenase/reductase pteridine reductase, NADPH-dihydropteridine reductase, PruA, pteridine reductase, pteridine reductase 1, pteridine reductase I, PTR1, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide phosphate), Tb-PR, TbPTR1, tcptr1

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.33 pteridine reductase

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Results	in table
720	AA Sequence
9	Application
1	CAS Registry Number
26	Cloned(Commentary)
44	Cofactor
12	Crystallization (Commentary)
5	Expression
53	General Information
81	IC50 Value
372	Inhibitors
13	kcat/KM [mM/s]
178	Ki Value [mM]
56	KM Value [mM]
4	Localization
15	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
73	Organism
2	Pathway
238	PDB ID
25	pH Optimum
5	pH Range
1	pH Stability
25	Protein Variants
13	Purification (Commentary)
5	Reaction
2	Reaction Type
65	Reference
4	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
128	Substrates and Products (Substrate)
22	Subunits
129	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Stability [°C]
17	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 1.5.1.33 - pteridine reductase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

135.45

7,8-dihydrobiopterin

Agrobacterium fabrum

Q7CZX3

recombinant wild-type enzyme, pH 6.0, 25°C

765008

2.77 - 32.26

7,8-dihydromonapterin

5 entries

25.24

7,8-dihydroneopterin

Agrobacterium fabrum

Q7CZX3

recombinant wild-type enzyme, pH 6.0, 25°C

765008

170 - 1700

dihydrobiopterin

2 entries

21 - 26

quinonoid 6,7-dimethyl-7,8-dihydropterin

2 entries

160 - 180

quinonoid dihydrobiopterin

2 entries

2.77

7,8-dihydromonapterin

Agrobacterium fabrum

Q7CZX3

recombinant mutant Y161A, pH 6.0, 25°C

765008

4.72

7,8-dihydromonapterin

Agrobacterium fabrum

Q7CZX3

recombinant mutant R24A, pH 6.0, 25°C

765008

6

7,8-dihydromonapterin

Agrobacterium fabrum

Q7CZX3

recombinant mutant Y161F/Y163F, pH 6.0, 25°C

765008

19.75

7,8-dihydromonapterin

Agrobacterium fabrum

Q7CZX3

recombinant mutant Y163F, pH 6.0, 25°C

765008

32.26

7,8-dihydromonapterin

Agrobacterium fabrum

Q7CZX3

recombinant wild-type enzyme, pH 6.0, 25°C

765008

170

dihydrobiopterin

Leishmania major

-

in 50 mM HEPES buffer, pH 7.4, at 25°C

725417

1700

dihydrobiopterin

Trypanosoma brucei

-

in 50 mM HEPES buffer, pH 7.4, at 25°C

725417

21

quinonoid 6,7-dimethyl-7,8-dihydropterin

Leishmania major

-

in 50 mM HEPES buffer, pH 7.4, at 25°C

725417

26

quinonoid 6,7-dimethyl-7,8-dihydropterin

Trypanosoma brucei

-

in 50 mM HEPES buffer, pH 7.4, at 25°C

725417

160

quinonoid dihydrobiopterin

Trypanosoma brucei

-

in 50 mM HEPES buffer, pH 7.4, at 25°C

725417

180

quinonoid dihydrobiopterin

Leishmania major

-

in 50 mM HEPES buffer, pH 7.4, at 25°C

725417