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1.5.1.33: pteridine reductase

This is an abbreviated version!
For detailed information about pteridine reductase, go to the full flat file.

Word Map on EC 1.5.1.33

Reaction

5,6,7,8-tetrahydrobiopterin
+ 2 NADP+ =
biopterin
 + 2 NADPH + 2 H+

Synonyms

Atu1130, EC 1.1.1.253, H region methotrexate resistance protein, LaPTR1, LbPTR1, LdPTR1, LmPTR1, LpPTR1, More, NADPH-dependent short-chain dehydrogenase/reductase pteridine reductase, NADPH-dihydropteridine reductase, PruA, pteridine reductase, pteridine reductase 1, pteridine reductase I, PTR1, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide phosphate), Tb-PR, TbPTR1, tcptr1

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.33 pteridine reductase

Specific Activity

Specific Activity on EC 1.5.1.33 - pteridine reductase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.28
recombinant mutant R24G, pH 6.0, 25°C, substrate 7,8-dihydromonapterin
1.71
recombinant mutant R24A, pH 6.0, 25°C, substrate 7,8-dihydromonapterin
2
-
pH 3.7, substrate biopterin
2.3
-
pH 3.7, substrate dihydrobiopterin
2.88
recombinant mutant Y161A, pH 6.0, 25°C, substrate 7,8-dihydromonapterin
4.13
recombinant mutant Y161F/Y163F, pH 6.0, 25°C, substrate 7,8-dihydromonapterin
4.77
recombinant wild-type enzyme, pH 6.0, 25°C, substrate 7,8-dihydromonapterin
5.03
recombinant wild-type enzyme, pH 6.0, 25°C, substrate 7,8-dihydroneopterin
8.84
recombinant mutant Y163F, pH 6.0, 25°C, substrate 7,8-dihydromonapterin
9.83
recombinant wild-type enzyme, pH 6.0, 25°C, substrate 7,8-dihydrobiopterin