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1.5.1.34: 6,7-dihydropteridine reductase

This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.

Word Map on EC 1.5.1.34

Reaction

a 5,6,7,8-tetrahydropteridine
+
NAD(P)+
=
a 6,7-dihydropteridine
 +
NAD(P)H
 +
H+

Synonyms

7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.34 6,7-dihydropteridine reductase

Engineering

Engineering on EC 1.5.1.34 - 6,7-dihydropteridine reductase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G151S
-
mutation found in children suffering from phenylketonuria due to enzyme deficiency
G19D
-
completely inactive
G23D
-
mutation found in children suffering from phenylketonuria due to enzyme deficiency, inactive mutant enzyme
T119insert
-
reduced activity
W104G
-
similar activity as wild-type
Y150E
-
lower kcat with 6-methyl-7,8-dyhydropterin than wild-type
Y150F
-
lower kcat with 6-methyl-7,8-dyhydropterin than wild-type
Y150H
-
lower kcat with 6-methyl-7,8-dyhydropterin than wild-type
Y150K
-
lower kcat with 6-methyl-7,8-dyhydropterin than wild-type
Y150S
-
lower kcat with 6-methyl-7,8-dyhydropterin than wild-type
A133S
A6V
-
no significant differences to wild-type
K150I
-
lower kcat for quinonoid dihydrobiopterin than wild-type
K150M
-
lower kcat for quinonoid dihydrobiopterin than wild-type
K150Q
-
lower kcat for quinonoid dihydrobiopterin than wild-type
N186A
-
lower kcat for quinonoid dihydrobiopterin than wild-type
W104F
-
no significant differences to wild-type
W86I
-
lower kcat for quinonoid dihydrobiopterin than wild-type
Y146F
Y146F/A133S
-
almost no activity with quinonoid 6,7-dimethyldihydropteridine, higher activity with quinoid dihydrobipterin than wild-type
Y146F/K150E
-
no activity with quinonoid 6,7-dimethyldihydropteridine, higher activity with quinoid dihydrobipterin than wild-type
Y146F/K150Q
-
lower kcat for quinonoid dihydrobiopterin than wild-type
Y146H
additional information
-
generation of lethal mutants of a65 and a60 strains. For a65 (leml/leml) and a60 (al/al), the reaction rate of total proteins is 0.373 and 3.352 microM/min/mg protein, respectively. The expression of BmDhpr is especially activated in the brain and sexual glands of lem mutant and the homozygous lethal mutant of al mutant