1.5.1.34: 6,7-dihydropteridine reductase
This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.
Word Map on EC 1.5.1.34
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1.5.1.34
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tetrahydrobiopterin
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hydroxylase
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bh4
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hyperphenylalaninemia
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neurotransmitter
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phenylketonuria
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biopterin
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pterins
-
dopamine
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quinonoid
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sepiapterin
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1.6.99.7
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cyclohydrolase
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6-pyruvoyl-tetrahydropterin
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5-hydroxytryptophan
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tetrahydropterin
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dihydrobiopterin
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l-dopa
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ptp
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folinic
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nadh-specific
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homovanillic
-
pterin-4a-carbinolamine
-
guthrie
-
6-pyruvoyl
-
dihydropterins
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gtpch
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medicine
- 1.5.1.34
- tetrahydrobiopterin
- hydroxylase
- bh4
- hyperphenylalaninemia
-
neurotransmitter
- phenylketonuria
- biopterin
- pterins
- dopamine
-
quinonoid
- sepiapterin
-
1.6.99.7
-
cyclohydrolase
- 6-pyruvoyl-tetrahydropterin
- 5-hydroxytryptophan
- tetrahydropterin
- dihydrobiopterin
- l-dopa
- ptp
-
folinic
-
nadh-specific
-
homovanillic
-
pterin-4a-carbinolamine
-
guthrie
-
6-pyruvoyl
- dihydropterins
- gtpch
- medicine
Reaction
Synonyms
7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)
ECTree
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Substrates Products
Substrates Products on EC 1.5.1.34 - 6,7-dihydropteridine reductase
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REACTION DIAGRAM
(6R,S)-6-hydroxy-methyltetrahydropterin + NAD(P)+
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low activity
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-
r
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
2-amino-4-hydroxy-6-methyl-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6-methyl-tetrahydropteridine + NAD(P)+
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-
-
?
2-amino-4-hydroxy-7-methyl-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-7-methyl-tetrahydropteridine + NAD(P)+
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-
-
?
5,6,7,8-tetrahydrobiopterin + NAD+
quinonoid dihydrobiopterin + NADH + H+
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-
-
-
r
5,6,7,8-tetrahydropteridine + NAD(P)+
6,7-dihydropteridine + NAD(P)H
enzyme is required for recycling of 6,7-dihydropteridine, in vivo regulation is related to growth phase
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r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
6,7-dimethyl-7,8-dihydropterin + NADH + H+
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r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
quinonoid 6,7-dimethyl dihydropteridine + NADH + H+
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r
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
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r
6,7-dimethyl-7,8-dihydropteridine + NADH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD+
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NADH is preferred in vitro compared to NADPH
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-
?
6,7-dimethyl-7,8-dihydropteridine + NADPH
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
6,7-dimethyldihydropterin + NADH + H+
6,7-dimethyltetrahydropterin + NAD+
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-
-
?
6-methyl-dihydropterin + NADH + H+
6-methyl-tetrahydropterin + NAD+
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-
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r
6-methyldihydropterin + NADH + H+
quinoid 6,6-dimethyldihydropterin + NAD+
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-
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r
a 6,7-dihydropteridine + NAD(P)H + H+
a 5,6,7,8-tetrahydropteridine + NAD(P)+
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-
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?
a 6,7-dihydropteridine + NADPH + H+
a 5,6,7,8-tetrahydropteridine + NADP+
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-
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?
dihydropteroylglutamic acid + NAD(P)H
tetrahydropteroylglutamate + NAD(P)+
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-
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?
quinoid 6-methyl-7,8-dihydropterin + NADH + H+
6-methyl-5,6,7,8-tetrahydropterin + NAD+
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-
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r
quinoid 7,8-(6H)-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
non-enzymatic reaction of quinoid 7,8-(6H)-dihydropterine to 7,8-dihydropterin
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-
?
quinonoid (6R)-D-threo-dihydrobiopterin + NADH + H+
?
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-
?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
quinonoid 6,7-dimethyl-7,8-dihydropteridine + NADH + H+
6,7-dimethyl-5,6,7,8-tetrahydropteridine + NAD+
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-
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r
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
quinonoid 6-methyl-7,8-dihydropterin + NADH + H+
6-methyl-5,6,7,8-tetrahydropterin + NAD+
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-
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r
quinonoid 7,8-(6H)-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
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-
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r
quinonoid 7,8-dihydropterin + NADH + H+
5,6,7,8-tetrahydropterin + NAD+
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-
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r
quinonoid dihydro-2-methylamino-4-hydroxy-6,7-dimethylpteridine + NAD(P)H
tetrahydro-2-methylamino-4-hydroxy-6,7-dimethylpteridine + NAD(P)+
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approx. one-third of activity with 2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropterid
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?
quinonoid dihydro-L-threo-neopterin + NAD(P)H
tetrahydro-L-threo-neopterin + NAD(P)+
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-
-
?
quinonoid dihydrobiopterin + NADH + H+
5,6,7,8-tetrahydrobiopterin + NAD+
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-
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r
quinonoid dihydromonapterin + NAD(P)H
tetrahydromonapterin + NAD(P)+
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-
-
?
quinonoid dihydroneopterin + NAD(P)H
tetrahydroneopterin + NAD(P)+
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-
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?
quinonoid-6-methyl-7,8-dihydrobiopterin + NADH + H+
6-methyl-7,8-dihydropterin + NAD+
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-
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r
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
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?
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
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NADH is 20fold more effective than NADPH
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?
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
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-
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?
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
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3% activity with NADPH
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?
2-amino-4-hydroxy-6,7-dimethyl-quinonoid-dihydropteridine + NAD(P)H
2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine + NAD(P)+
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-
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?
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
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-
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?
6,7-dihydropteridine + NADH
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
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-
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?
6,7-dihydropteridine + NADH
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
last step of recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopteridine essential for aromatic amino acid hydroxylases and nitric oxide synthases, regulatory mechanism involve H2O2, enzyme inactivation because of H2O2 accumulation in the epidermis contributes to the pathomechanism of vitiligo
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-
?
5,6,7,8-tetrahydropteridine + NADP+
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r
6,7-dihydropteridine + NADPH + H+
5,6,7,8-tetrahydropteridine + NADP+
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r
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
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?
6,7-dimethyl-7,8-dihydropteridine + NADPH
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
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-
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?
6,7-dimethyl-7,8-dihydropteridine + NADPH
(6R)-L-erythro-6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + NADP+
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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?
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
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?
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
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?
6,7-dimethyl-7,8-dihydropterin + NADPH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
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as the quinonoid forms of pterines are very unstable, the reaction is carried out with a dimethyl analogue in the presence of H2O2 and radish peroxidase to allow the continuous formation of 6,7-dimethyl-7,8-dihydropterine, activity is 25fold higher than the nitroreductase activity 2,4-dinitrophenol
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?
dihydrobiopterin + NADH + H+
tetrahydrobiopterin + NAD+
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pH 7.4, 37°C
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?
dihydrofolate + NADPH
tetrahydrofolate + NADP+
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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?
tetrahydrobiopterin + NAD(P)+
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?
quinoid dihydrobiopterin + NAD(P)H
tetrahydrobiopterin + NAD(P)+
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NADH is 2.5fold more effective than NADPH
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?
quinoid dihydrobiopterin + NAD(P)H
tetrahydrobiopterin + NAD(P)+
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specific for NADH
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?
quinoid dihydrobiopterin + NAD(P)H
tetrahydrobiopterin + NAD(P)+
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?
6,6-dimethyltetrahydropterin + NAD(P)+
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?
quinonoid 6,6-dimethyldihydropterin + NAD(P)H
6,6-dimethyltetrahydropterin + NAD(P)+
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-
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?
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
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?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
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enzyme from adrenal medulla
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?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
quinonoid 6,7-dimethyl-7,8-(6H)-dihydropterin + NAD(P)H
6,7-dimethyl-5,6,7,8-tetrahydropterin + NAD(P)+
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no activity with 6,6,8-trimethyl-7,8-(6H)-dihydropterin
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?
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
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?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
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NADPH-specific enzyme from liver, NADPH is 660times more effective than NADH
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-
?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H
6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+
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-
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?
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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-
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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may also have an important role in regulation of catecholamine synthesis
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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more specific for NADH, 50% activity with NADPH, no activity with biopterin and 7,8-dihydrobiopterin
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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enzyme also has pterin-independent NADH and NADPH oxidoreductase activity with potassium ferricyanide
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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essential enzyme component of the complex system catalyzing hydroxylation of phenylalanine, tyrosine and tryptophan
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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enzyme prefers NADH
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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absolutely specific for quinonoid dihydro-isomer corresponding to 7,8-dihydropterins
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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essential component of the hepatic phenylalanine hydroxylating system
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?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
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no marked specificity for the pteridine cofactor that occurs naturally in this organism L-threo-neopterin
-
?
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H
5,6,7,8-tetrahydrobiopterin + NAD(P)+
-
essential component of catecholamine biosynthetic metabolism
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?
5,6,7,8-tetrahydropterin + NADP+
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r
quinonoid 7,8-(6H)-dihydropterin + NADPH + H+
5,6,7,8-tetrahydropterin + NADP+
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r
5,6,7,8-tetrahydropterin + NADP+
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r
quinonoid 7,8-dihydropterin + NADPH + H+
5,6,7,8-tetrahydropterin + NADP+
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r
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
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?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
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-
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?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
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-
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?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
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?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
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-
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?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
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-
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?
quinonoid dihydrobiopterin + NADH + H+
6R-(1'R,2'R)-5,6,7,8-tetrahydrobiopterin + NAD+
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-
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?
?
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essential part of the hydroxylating system of the aromatic amino acids phenylalanine, tyrosine and tryptophan, reduces quinonoid dihydropterine to regenerate tetrahydrobiopterin, main metabolic derangements caused by DHPR deficiency are hyperphenylalaninaemia and impaired production of the monoamine neurotransmitters dopamine, noradrenaline and serotonin, DHPR deficiency patients can develop severe and progressive neurological damage
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additional information
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substrate specificity, enzyme shows selectivity for pterin substrates with a 6-(1', 2'-dihydroxypropyl) substitution
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additional information
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substrate specificity, enzyme shows selectivity for pterin substrates with a 6-(1', 2'-dihydroxypropyl) substitution
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?
additional information
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in vivo role as dihydropteridine reductase involved in aromatic amino acids metabolism suggested
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?
additional information
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enzyme shows nitroreductase activity with several different substrates such as 2,4-dinitrophenol, 2,4-dinitrobenzoate and nitrofurazone
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?
additional information
?
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no activity with potassium ferricyanide, 6-biopterin, and 6-methyl-7,8-dihydropterine
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?
additional information
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Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
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no activity with potassium ferricyanide, 6-biopterin, and 6-methyl-7,8-dihydropterine
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?