1.5.1.46: agroclavine dehydrogenase
This is an abbreviated version!
For detailed information about agroclavine dehydrogenase, go to the full flat file.
Reaction
Synonyms
agroclavine synthase, EasG
ECTree
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Substrates Products
Substrates Products on EC 1.5.1.46 - agroclavine dehydrogenase
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REACTION DIAGRAM
(8beta,10beta)-6-amino-8-methyl-6,7-didehydroergolin-6-ium + NADPH + H+
festuclavine + NADP+
-
-
-
-
?
6,8-dimethyl-6,7,8,9-tetradehydroergoline + NADPH + H+
agroclavine + NADP+
-
-
-
-
?
chanoclavine-I aldehyde + GSH + NADPH + H+
agroclavine + GSSG + NADP+
-
the reaction occurs only in the presence of reduced glutathione
-
-
?
chanoclavine-I aldehyde + NADPH + H+
festuclavine + pyroclavine + NADP+
-
-
-
-
?
agroclavine + NAD+
54% conversion compared to NADPH, in the presence of reduced glutathione
-
-
?
chanoclavine-I aldehyde + NADH + H+
agroclavine + NAD+
the reaction occurs only in the presence of reduced glutathione (conversion rate of 54%)
-
-
?
agroclavine + NADP+
the reaction occurs only in the presence of reduced glutathione or beta-mercaptoethanol or dithiothreitol
-
-
?
chanoclavine-I aldehyde + NADPH + H+
agroclavine + NADP+
the reaction occurs only in the presence of the thiolation agents reduced glutathione (conversion rate of 59%) or 2-mercaptoethanol (conversion rate of 99%) and dithiothreitol (conversion rate of 67%). No product formation is detected in the incubation mixture with L-ascorbic acid instead of GSH
-
-
?