1.5.1.48: 2-methyl-1-pyrroline reductase

This is an abbreviated version!
For detailed information about 2-methyl-1-pyrroline reductase, go to the full flat file.

Reaction

Synonyms

(R)-imine reductase, (R)-IRED, PlRIR

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.48 2-methyl-1-pyrroline reductase

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All data fields related to EC 1.5.1.48
Results	in table
2	Activating Compound
3	AA Sequence
1	Application
2	Cloned(Commentary)
3	Cofactor
1	General Information
10	Inhibitors
12	kcat/KM [mM/s]
13	KM Value [mM]
2	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
5	Organism
16	PDB ID
4	pH Optimum
2	pH Range
3	Protein Variants
2	Purification (Commentary)
1	Reaction
5	Reference
2	Specific Activity [micromol/min/mg]
54	Substrates and Products (Substrate)
2	Subunits
5	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Stability [°C]
11	Turnover Number [1/s]

Engineering

Engineering on EC 1.5.1.48 - 2-methyl-1-pyrroline reductase

for references in articles please use BRENDA:EC1.5.1.48

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D172A

Streptomyces sp. GF3587

M4ZRJ3

site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme and also reduced enantioselectivity depending on the substrate, overview

742291

D172K

Streptomyces sp. GF3587

M4ZRJ3

site-directed mutagenesis, the mutant shows reduced activity compared to the wild-type enzyme and also reduced enantioselectivity depending on the substrate, overview

742291

additional information

Streptomyces sp. GF3587

M4ZRJ3

creation of a recombinant whole-cell biocatalyst for the asymmetric reduction of prochiral imines by recombinant overexpression of the (R)-imine reductase from Streptomyces sp. GF3587 in Escherichia coli

742291