Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.5.1.49: 1-pyrroline-2-carboxylate reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about 1-pyrroline-2-carboxylate reductase [NAD(P)H], go to the full flat file.

Reaction

L-proline
+
NAD(P)+
=
1-pyrroline-2-carboxylate
+
NAD(P)H
+
H+

Synonyms

LhpH

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]

Cofactor

Cofactor on EC 1.5.1.49 - 1-pyrroline-2-carboxylate reductase [NAD(P)H]

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NAD+
in the oxidization of L-proline the ratio of NADP+ to NAD+ in kcat/Km value is about 150:1
NADH
the preferred cofactor is NADPH, lower activity with NADH. The kcat/Km value for DELTA1-pyrroline-2-carboxylate in the presence of NADH is 5.6fold lower than that in the presence of NADPH, mainly caused by the 12fold lower kcat value
NADP+
in the oxidization of L-proline the ratio of NADP+ to NAD+ in kcat/Km value is about 150:1
NADPH
the preferred cofactor is NADPH, lower activity with NADH. The kcat/Km value for DELTA1-pyrroline-2-carboxylate in the presence of NADH is 5.6fold lower than that in the presence of NADPH, mainly caused by the 12fold lower kcat value