1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP+)

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For detailed information about methylenetetrahydrofolate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.5.1.5

1.5.1.5

one-carbon

cyclohydrolase

thymidylate

trifunctional

methenyltetrahydrofolate

5,10-methenyltetrahydrofolate

10-formyltetrahydrofolate

mthfd1l

folate-dependent

formyltetrahydrofolate

folate-mediated

c1-tetrahydrofolate

3.5.4.9

transcobalamin

10-formyl-thf

6.3.4.3

remethylation

5,10-methenyl-thf

1-carbon

dehydrogenase-cyclohydrolase

megaloblastic

medicine

Reaction

Synonyms

5, 10-methylenetetrahydrofolate dehydrogenase, 5,10-CH2-THF dehydrogenase, 5,10-mehtylene tetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ADE3, bmMTHFD, CH2-THF dehydrogenase, Cpe FolD, dehydrogenasse-cyclohydrolase-synthetase, DHCH, DHCH1, FolD, methylene tetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase, methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, MIS1, mitochondrial methylenetetrahydrofolate dehydrogenase, MTHFD, MTHFD1, MTHFD1 protein, MTHFD2, MTHFD2 protein, MTHFD2L, MTHFDC, N5,N10-methylenetetrahydrofolate dehydrogenase, N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase, NADP-dependent 5,10-methylene-THF dehydrogenase

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)

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Results	in table
6	Activating Compound
45268	AA Sequence
3	Application
1	CAS Registry Number
21	Cloned(Commentary)
64	Cofactor
5	Crystallization (Commentary)
236	Disease/ Diagnostics
1	Expression
20	General Information
10	General Stability
14	IC50 Value
56	Inhibitors
20	kcat/KM [mM/s]
9	Ki Value [mM]
82	KM Value [mM]
22	Localization
14	Metals/Ions
30	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
421	Organism
16	Pathway
72	PDB ID
13	pH Optimum
3	pH Range
16	Protein Variants
36	Purification (Commentary)
1	Reaction
6	Reaction Type
66	Reference
57	Source Tissue
34	Specific Activity [micromol/min/mg]
13	Storage Stability
91	Substrates and Products (Substrate)
19	Subunits
73	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
28	Turnover Number [1/s]

KM Value

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KM Value on EC 1.5.1.5 - methylenetetrahydrofolate dehydrogenase (NADP+)

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0.228

(6R,S)-5,10-methylenetetrahydrofolate

Clostridium perfringens

Q0TPD4

pH 7.6, temperature not specified in the publication

743250

0.068 - 0.302

5,10-methenyltetrahydrofolate

5 entries

0.12

5,10-methylene-tetrahydrofolate

2 entries

0.0011 - 4.76

5,10-methylenetetrahydrofolate

21 entries

1.6

5,10-Methylenetetrahydropteroate

Clostridium cylindrosporum

392310

0.123 - 0.133

5,10-methylenetetrahydropteroylglutamate

2 entries

0.302 - 0.359

5,10-methylenetetrahydropteroylpentaglutamate

2 entries

0.04 - 0.153

5,10-methylenetetrahydropteroylpoly-L-glutamate

4 entries

0.0088

5,10-methylenetetrahydropteroyltriglutamate

Clostridium cylindrosporum

392310

0.21

DL-tetrahydrofolic acid

Pisum sativum

392326

0.79

formaldehyde

Pisum sativum

392326

0.147 - 0.507

NAD+

2 entries

0.0004 - 0.69

NADP+

24 entries

0.0077

tetrahydropteroylglutamic acid

Pisum sativum

1518

0.021

tetrahydropteroylmonoglutamate

Pisum sativum

209737

0.025

Tetrahydropteroylpentaglutamate

Pisum sativum

209737

additional information

6 entries