1.5.1.53: methylenetetrahydrofolate reductase (NADPH)

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase (NADPH), go to the full flat file.

Reaction

Synonyms

5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, MET13, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH2), methylenetetrahydrofolic acid reductase, MTHFR, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.53 methylenetetrahydrofolate reductase (NADPH)

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Results	in table
3	AA Sequence
3	Application
1	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
4	General Information
1	General Stability
20	Inhibitors
5	Ki Value [mM]
28	KM Value [mM]
4	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
15	Organism
4	Pathway
3	pH Optimum
1	Posttranslational Modification
3	Protein Variants
5	Purification (Commentary)
1	Reaction
15	Reference
11	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
28	Substrates and Products (Substrate)
3	Subunits
17	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
3	Temperature Stability [°C]
4	Turnover Number [1/s]

Sequence

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Sequence on EC 1.5.1.53 - methylenetetrahydrofolate reductase (NADPH)

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTIONThe reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

D4A7E8 pBLAST

D4A7E8_RAT

Rattus norvegicus

660

0

75173

TrEMBL

Show Sequence

-

P42898 pBLAST

MTHR_HUMAN

Homo sapiens

656

0

74597

Swiss-Prot

Show Sequence

-

P53128 pBLAST

MTHR2_YEAST

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

600

0

68560

Swiss-Prot

Show Sequence

-

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