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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
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-
?
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
6,7-dimethyl-7,8-dihydropterin + NADH + H+
6,7-dimethyl-5,6,7,8-tetrahydropterin + NADP+
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?
dihydrobiopterin + NADPH + H+
tetrahydrobiopterin + NADP+
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-
-
?
dihydrofolate + NADPH + H+
tetrahydrofolate + NADP+
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-
-
-
?
NADPH + H+ + oxidized menadione
NADP+ + reduced menadione
additional information
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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-
-
?
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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-
-
?
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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-
-
-
?
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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NADH is a poor cofactor
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-
?
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
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-
-
-
?
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
-
-
-
?
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
-
-
-
?
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
-
-
-
?
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
-
-
-
-
?
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
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-
-
-
?
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
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-
-
-
?
NADPH + H+ + oxidized menadione
NADP+ + reduced menadione
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-
-
-
?
NADPH + H+ + oxidized menadione
NADP+ + reduced menadione
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-
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?
additional information
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enzyme is specific for the (+) diastereoisomer of 5,10-methylenetetrahydrofolate as its physiological substrate. In addition, the enzyme exhibits a strong NADPH-specific diaphorase (reduced-NAD:lipoamide oxidoreductase, EC 1.8.1.4) or menadione reductase (reduced-NAD(P):(acceptor) oxidoreductase, EC 1.6.5.2 ) activity
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additional information
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no substrate: dihydrofolate
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additional information
?
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under Vmax conditions, the turnover numbers for the NADPH-linked reductions of the quinonoid forms of 6,7-dimethyldihydropterin, dihydrobiopterin, and dihydrofolate are all about the same as that for the reduction of methylenetetrahydrofolate. The reduction of quinonoid dihydropterins is inhibited by S-adenosyl-L-methionine and dihydropteroylhexaglutamate
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