1.5.1.54: methylenetetrahydrofolate reductase (NADH)
This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase (NADH), go to the full flat file.
Reaction
Synonyms
5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, metF, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolic acid reductase, MSMEG_6596, MSMEG_6649, MTHFR1, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase
ECTree
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Substrates Products
Substrates Products on EC 1.5.1.54 - methylenetetrahydrofolate reductase (NADH)
for references in articles please use BRENDA:EC1.5.1.54
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REACTION DIAGRAM
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
Substrates: -
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5,10-methylenetetrahydrofolate + reduced methylene blue
5-methyltetrahydrofolate + methylene blue
5-methyltetrahydrofolate + methylene blue
5,10-methylenetetrahydrofolate + reduced methylene blue
NAD+ + menadiol
NADH + H+ + menadione
Substrates: reaction of EC 1.6.5.2
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5-methyltetrahydrofolate + menadione
Substrates: -
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5,10-methylenetetrahydrofolate + menadiol
5-methyltetrahydrofolate + menadione
Substrates: -
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5,10-methylenetetrahydrofolate + menadiol
5-methyltetrahydrofolate + menadione
Substrates: -
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5-methyltetrahydrofolate + NAD+
Substrates: -
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
Substrates: -
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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Substrates: -
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
Blautia producta Marburg
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Substrates: -
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
Substrates: -
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
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5-methyltetrahydrofolate + methylene blue
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Substrates: -
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5,10-methylenetetrahydrofolate + reduced methylene blue
5-methyltetrahydrofolate + methylene blue
Blautia producta Marburg
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Substrates: -
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5,10-methylenetetrahydrofolate + menadiol
Substrates: -
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5-methyltetrahydrofolate + menadione
5,10-methylenetetrahydrofolate + menadiol
Substrates: -
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5-methyltetrahydrofolate + menadione
5,10-methylenetetrahydrofolate + menadiol
Substrates: -
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5-methyltetrahydrofolate + menadione
5,10-methylenetetrahydrofolate + menadiol
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5,10-methylenetetrahydrofolate + reduced methylene blue
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Substrates: -
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5-methyltetrahydrofolate + methylene blue
5,10-methylenetetrahydrofolate + reduced methylene blue
Blautia producta Marburg
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Substrates: -
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NAD+ + ferrocyanide
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NADH + H+ + ferricyanide
NAD+ + ferrocyanide
Substrates: -
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NADH + H+ + menadione
NAD+ + menadiol
Substrates: reaction of EC 1.6.5.2
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NAD+ + reduced methylviologen
Substrates: -
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NADH + H+ + methylviologen
NAD+ + reduced methylviologen
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Substrates: no substrate: ferredoxin
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additional information
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Substrates: no substrate: ferredoxin
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additional information
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Substrates: the enzyme catalyzes the methylenetetrahydrofolate reduction with methylene blue as an artificial electron donor. The oxidation of methyltetrahydrofolate is mediated with methylene blue as the electron acceptor. Neither NAD+ nor viologen dyes can replace methylene blue in this reaction
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additional information
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Blautia producta Marburg
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Substrates: the enzyme catalyzes the methylenetetrahydrofolate reduction with methylene blue as an artificial electron donor. The oxidation of methyltetrahydrofolate is mediated with methylene blue as the electron acceptor. Neither NAD+ nor viologen dyes can replace methylene blue in this reaction
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