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1.5.1.54: methylenetetrahydrofolate reductase (NADH)

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase (NADH), go to the full flat file.

Reaction

5-methyltetrahydrofolate
+
NAD+
=
5,10-methylenetetrahydrofolate
+
NADH
+
H+

Synonyms

5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, metF, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolic acid reductase, MSMEG_6596, MSMEG_6649, MTHFR1, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.54 methylenetetrahydrofolate reductase (NADH)

Substrates Products

Substrates Products on EC 1.5.1.54 - methylenetetrahydrofolate reductase (NADH)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5,10-methylenetetrahydrofolate + menadiol
5-methyltetrahydrofolate + menadione
show the reaction diagram
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
show the reaction diagram
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
show the reaction diagram
-
-
-
?
5,10-methylenetetrahydrofolate + reduced methylene blue
5-methyltetrahydrofolate + methylene blue
show the reaction diagram
5-methyltetrahydrofolate + menadione
5,10-methylenetetrahydrofolate + menadiol
show the reaction diagram
5-methyltetrahydrofolate + methylene blue
5,10-methylenetetrahydrofolate + reduced methylene blue
show the reaction diagram
NAD+ + menadiol
NADH + H+ + menadione
show the reaction diagram
reaction of EC 1.6.5.2
-
-
r
NADH + H+ + ferricyanide
NAD+ + ferrocyanide
show the reaction diagram
NADH + H+ + menadione
NAD+ + menadiol
show the reaction diagram
NADH + H+ + methylviologen
NAD+ + reduced methylviologen
show the reaction diagram
additional information
?
-