1.5.1.54: methylenetetrahydrofolate reductase (NADH)

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase (NADH), go to the full flat file.

Reaction

Synonyms

5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, metF, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolic acid reductase, MSMEG_6596, MSMEG_6649, MTHFR1, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.54 methylenetetrahydrofolate reductase (NADH)

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Results	in table
3	Activating Compound
8	AA Sequence
1	Application
3	Cloned(Commentary)
13	Cofactor
5	Crystallization (Commentary)
5	General Information
1	General Stability
7	Inhibitors
4	kcat/KM [mM/s]
6	Ki Value [mM]
34	KM Value [mM]
2	Localization
1	Metals/Ions
7	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
23	Organism
8	Pathway
13	Protein Variants
3	Purification (Commentary)
1	Reaction
21	Reference
3	Specific Activity [micromol/min/mg]
1	Storage Stability
38	Substrates and Products (Substrate)
11	Subunits
25	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
19	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.5.1.54 - methylenetetrahydrofolate reductase (NADH)

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5-methyltetrahydrofolate:NAD+ oxidoreductase

A flavoprotein (FAD). The enzyme, found in plants and some bacteria, catalyses the reversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using NADH as the electron donor. It play an important role in folate metabolism by regulating the distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. These proteins either contain a C-terminal domain that does not mediate allosteric regulation (as in plants) or lack this domain entirely (as in Escherichia coli). As a result, the plant enzymes are not inhibited by S-adenosyl-L-methionine, unlike other eukaryotic enzymes, and catalyse a reversible reaction. cf. EC 1.5.1.53, methylenetetrahydrofolate reductase (NADPH); EC 1.5.1.20, methylenetetrahydrofolate reductase [NAD(P)H]; and EC 1.5.7.1, methylenetetrahydrofolate reductase (ferredoxin).