1.5.1.6: formyltetrahydrofolate dehydrogenase
This is an abbreviated version!
For detailed information about formyltetrahydrofolate dehydrogenase, go to the full flat file.
Reaction
Synonyms
10-FDH, 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, 10-fTHF dehydrogenase, 10-FTHFDH, ALDH1L1, ALDH1L2, dehydrogenase, formyltetrahydrofolate, FBP-CI, FBP-CI proteins, FDH, folate-binding proteins, cytosol I, More, mtFDH, N10-formyltetrahydrofolate dehydrogenase, proteins, folate-binding, cytosol I
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Posttranslational Modification
Posttranslational Modification on EC 1.5.1.6 - formyltetrahydrofolate dehydrogenase
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phospholipoprotein
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the broad specificity human 4-phosphopantetheinyl transferase phosphopantetheinylates apo-FDH to holoenzyme and thus activates FDH catalysis. Silencing 4-phosphopantetheinyl transferase by small interfering RNA in A-549 cells prevents FDH modification
proteolytic modification
sequence contains a 22 amino acid N-terminal mitochondrial translocation signal
additional information
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protein with conserved potential N-glycosylation sites, protein kinase phosphorylation sites, and N-myristoylation sites, post-translational modification may be important for the function
additional information
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S375 is the putative site of enzyme phosphopantetheinylation
additional information
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FDH requires posttranslational modification to become a functional enzyme (4'-phosphopantetheine prosthetic group)