1.5.1.B5: DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)
This is an abbreviated version!
For detailed information about DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH), go to the full flat file.
Word Map on EC 1.5.1.B5
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1.5.1.B5
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sulfatases
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mucopolysaccharidosis
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formylglycine-generating
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metachromatic
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sulfatase-modifying
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leukodystrophy
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ichthyosis
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formylglycine
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aav-mediated
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x-linked
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co-delivery
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intracerebral
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infantile
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autosomal-recessive
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ataxia
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mpsiiia
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adeno-associated
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posttranslationally
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sulfamidase
- 1.5.1.B5
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sulfatases
-
mucopolysaccharidosis
-
formylglycine-generating
-
metachromatic
-
sulfatase-modifying
-
leukodystrophy
-
ichthyosis
-
formylglycine
-
aav-mediated
-
x-linked
-
co-delivery
-
intracerebral
-
infantile
-
autosomal-recessive
-
ataxia
-
mpsiiia
-
adeno-associated
-
posttranslationally
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sulfamidase
Reaction
Synonyms
DELTA-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, NADH-dependent Pyr2C reductase, Pyr2C reductase, TlLhpI, tlPyr2C
ECTree
1.5.1.B5 DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)Advanced search results
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General Information on EC 1.5.1.B5 - DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)
for references in articles please use BRENDA:EC1.5.1.B5
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
metabolism
physiological function
evolution
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the enzyme belongs to the ornithine cyclodeaminase/l-crystallin (OCD/CRYM) superfamily
evolution
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the enzyme belongs to the ornithine cyclodeaminase/l-crystallin (OCD/CRYM) superfamily
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metabolism
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the enzyme performs the second step of the trans-3-hydroxy-L-proline (T3LHyp) degradation pathway
metabolism
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the enzyme performs the second step of the trans-3-hydroxy-L-proline (T3LHyp) degradation pathway
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metabolism
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the enzyme performs the second step of the trans-3-hydroxy-L-proline (T3LHyp) degradation pathway
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metabolism
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the enzyme is involved in the trans-3-hydroxy-L-proline metabolism
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metabolism
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the enzyme performs the second step of the trans-3-hydroxy-L-proline (T3LHyp) degradation pathway
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metabolism
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the enzyme performs the second step of the trans-3-hydroxy-L-proline (T3LHyp) degradation pathway
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physiological function
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approximately 40% of L-proline in collagen are post-translationally converted by proline hydroxylases into the isomers trans-4-hydroxy-L-proline (T4LHyp) and trans-3-hydroxy-L-proline (T3LHyp). The isomers trans-3-hydroxy-L-proline (T3LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are major components of mammalian collagen. T4LHyp follows two distinct degradation pathways in bacteria and mammals, while T3LHyp is metabolized by a two-step metabolic pathway that is conserved in bacteria and mammals, which involves a T3LHyp dehydratase and a DELTA1-pyrroline-2-carboxylate (Pyr2C) reductase
physiological function
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approximately 40% of L-proline in collagen are post-translationally converted by proline hydroxylases into the isomers trans-4-hydroxy-L-proline (T4LHyp) and trans-3-hydroxy-L-proline (T3LHyp). The isomers trans-3-hydroxy-L-proline (T3LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are major components of mammalian collagen. T4LHyp follows two distinct degradation pathways in bacteria and mammals, while T3LHyp is metabolized by a two-step metabolic pathway that is conserved in bacteria and mammals, which involves a T3LHyp dehydratase and a DELTA1-pyrroline-2-carboxylate (Pyr2C) reductase
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physiological function
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approximately 40% of L-proline in collagen are post-translationally converted by proline hydroxylases into the isomers trans-4-hydroxy-L-proline (T4LHyp) and trans-3-hydroxy-L-proline (T3LHyp). The isomers trans-3-hydroxy-L-proline (T3LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are major components of mammalian collagen. T4LHyp follows two distinct degradation pathways in bacteria and mammals, while T3LHyp is metabolized by a two-step metabolic pathway that is conserved in bacteria and mammals, which involves a T3LHyp dehydratase and a DELTA1-pyrroline-2-carboxylate (Pyr2C) reductase
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physiological function
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approximately 40% of L-proline in collagen are post-translationally converted by proline hydroxylases into the isomers trans-4-hydroxy-L-proline (T4LHyp) and trans-3-hydroxy-L-proline (T3LHyp). The isomers trans-3-hydroxy-L-proline (T3LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are major components of mammalian collagen. T4LHyp follows two distinct degradation pathways in bacteria and mammals, while T3LHyp is metabolized by a two-step metabolic pathway that is conserved in bacteria and mammals, which involves a T3LHyp dehydratase and a DELTA1-pyrroline-2-carboxylate (Pyr2C) reductase
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physiological function
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approximately 40% of L-proline in collagen are post-translationally converted by proline hydroxylases into the isomers trans-4-hydroxy-L-proline (T4LHyp) and trans-3-hydroxy-L-proline (T3LHyp). The isomers trans-3-hydroxy-L-proline (T3LHyp) and trans-4-hydroxy-L-proline (T4LHyp) are major components of mammalian collagen. T4LHyp follows two distinct degradation pathways in bacteria and mammals, while T3LHyp is metabolized by a two-step metabolic pathway that is conserved in bacteria and mammals, which involves a T3LHyp dehydratase and a DELTA1-pyrroline-2-carboxylate (Pyr2C) reductase
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