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1.5.1.B5: DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)

This is an abbreviated version!
For detailed information about DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH), go to the full flat file.

Word Map on EC 1.5.1.B5

Reaction

L-pipecolate
+
NAD+
=
DELTA1-piperideine-2-carboxylate
+
NADH
+
H+

Synonyms

DELTA-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, NADH-dependent Pyr2C reductase, Pyr2C reductase, TlLhpI, tlPyr2C

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.B5 DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)

pH Range

pH Range on EC 1.5.1.B5 - DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 12
H3ZMH3; H3ZMH4
pH 10.0: about 75% of maximal activity, pH 12.0: about 85% of maximal activity
5 - 11
H3ZMH3; H3ZMH4
pH 5.0: about 40% of maximal activity, pH 11.0: about 80% of maximal activity
6 - 10
-
the mutant R43A shows highest activity at pH 7.0, moderate to higher activity at pH 8.0 and pH 6.0, but lower activity at pH 10.0. The wild-type enzyme shows contantly high activity at pH 6.0-10.0