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1.5.3.1: sarcosine oxidase (formaldehyde-forming)

This is an abbreviated version!
For detailed information about sarcosine oxidase (formaldehyde-forming), go to the full flat file.

Word Map on EC 1.5.3.1

Reaction

sarcosine
+
H2O
+
O2
=
glycine
+
formaldehyde
+
H2O2

Synonyms

heterotetrameric sarcosine oxidase, L-pipecolate oxidase, L-pipecolic acid oxidase, monomeric sarcosine oxidase, MSOX, PSO, sarcosine : oxygen oxidoreductase (demethylating), sarcosine oxidase, sarcosine: O2 oxidoreductase, sarcosine:oxygen oxidoreductase (demethylating), SO, SO-U96, SOX, SoxA, trd_1773, TSOX

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.1 sarcosine oxidase (formaldehyde-forming)

Inhibitors

Inhibitors on EC 1.5.3.1 - sarcosine oxidase (formaldehyde-forming)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
slight
5-deaza-FAD
-
competitive inhibition of flavinylation of apoenzyme
acetaldehyde
-
-
acetate
AgNO3
-
2 mM, 0% relative activity
diethyldicarbonate
-
-
formaldehyde
-
-
Hydroxylamine hydrochloride
-
-
iodoacetamide
iodoacetate
iodoacetic acid
-
-
Methoxyacetate
-
competitive
Methoxyacetic acid
-
-
methylthioacetate
N-(cyclopropyl)glycin
suicide substrate
N-(cyclpopropyl)glycine
-
mechanism-based inhibitor, discussion of mechanism
N-bromosuccinimide
N-cyclopropylglycine
reaction leads to an inactivated species. The polar mechanism is energetically the most favorable. The first rate-limiting step is the N-cyclopropylglycine binding to the flavin ring which simultaneously proceeds with the ring-opening of the N-cyclopropylglycine cyclopropyl group. This step corresponds to the nucleophilic attack of the cyclopropyl group (C3 atom) to the flavin ring (C4a atom)
-
N-ethylmaleimide
o-phenanthroline
p-chloromercuribenzoate
phenylhydrazine
-
slight
propionate
propionic acid
-
-
pyrrole-2-carboxylate
sodium lauryl sulfate
-
2 mM, 0% relative activity
sulfit
-
nearly complete inhibition (93%) of activity when assays are conducted in the presence of excess sulfite
-
Tween 80
-
strong inhibition
additional information
-