1.5.3.1: sarcosine oxidase (formaldehyde-forming)
This is an abbreviated version!
For detailed information about sarcosine oxidase (formaldehyde-forming), go to the full flat file.
Word Map on EC 1.5.3.1
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1.5.3.1
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flavin
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fad
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heterotetrameric
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n-methylglycine
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creatininase
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amidinohydrolase
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n-methyltryptophan
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corynebacterial
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flavinylation
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diagnostics
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analysis
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medicine
- 1.5.3.1
- flavin
- fad
-
heterotetrameric
- n-methylglycine
- creatininase
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amidinohydrolase
- n-methyltryptophan
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corynebacterial
-
flavinylation
- diagnostics
- analysis
- medicine
Reaction
Synonyms
heterotetrameric sarcosine oxidase, L-pipecolate oxidase, L-pipecolic acid oxidase, monomeric sarcosine oxidase, MSOX, PSO, sarcosine : oxygen oxidoreductase (demethylating), sarcosine oxidase, sarcosine: O2 oxidoreductase, sarcosine:oxygen oxidoreductase (demethylating), SO, SO-U96, SOX, SoxA, trd_1773, TSOX
ECTree
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Inhibitors
Inhibitors on EC 1.5.3.1 - sarcosine oxidase (formaldehyde-forming)
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5-deaza-FAD
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competitive inhibition of flavinylation of apoenzyme
N-(cyclpopropyl)glycine
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mechanism-based inhibitor, discussion of mechanism
N-cyclopropylglycine
reaction leads to an inactivated species. The polar mechanism is energetically the most favorable. The first rate-limiting step is the N-cyclopropylglycine binding to the flavin ring which simultaneously proceeds with the ring-opening of the N-cyclopropylglycine cyclopropyl group. This step corresponds to the nucleophilic attack of the cyclopropyl group (C3 atom) to the flavin ring (C4a atom)
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sulfit
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nearly complete inhibition (93%) of activity when assays are conducted in the presence of excess sulfite
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iodoacetamide
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inactivation by modification of 2 specific lysine residues, one of which is Lys358, pH-depedency of inactivation in presence and absence of competitive inhibitor acetate lowerig the pKa for the epsilon-amino groups, inactivation kinetics at different pH-values
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comparison of complexes with wild-type and mutant Y317F
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comparison of complexes with wild-type and mutant Y317F
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no inhibition by Tween 20 and Triton X-100
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