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1.5.3.17: non-specific polyamine oxidase

This is an abbreviated version!
For detailed information about non-specific polyamine oxidase, go to the full flat file.

Word Map on EC 1.5.3.17

Reaction

N1-acetylspermidine
+
O2
 +
H2O
=
putrescine
 +
3-acetamidopropanal
 +
H2O2

Synonyms

AtPAO2, AtPAO3, AtPAO4, AtPAO5, Bjpao1, Bjpao2, EC 1.5.3.11, Fms1, LC036642, OsPAO1, PAO, PAO1, PAO2, PAO3, PAO5, polyamine oxidase 1, SelPAO5, slr5093, T-Spm oxidase, thermospermine oxidase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.17 non-specific polyamine oxidase

Expression

Expression on EC 1.5.3.17 - non-specific polyamine oxidase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
AtPAO2 uORF has a regulatory role in regulating AtPAO2 expression. The fact that uORFs are commonly found in plant polyamine oxidase genes is relevant, implying that regulatory elements in the 5'-UTR of polyamine biosynthetic and catabolic genes might finely control the intracellular concentration of polyamines in plant development and stress responses
AtPAO3 mRNA rapidly accumulats in wounded plants 1 h after wounding and returns to almost basal levels 6 h thereafter. Seedlings treated with flagellin 22, a pathogen elicitor that activates the plant basal defense, exhibits AtPAO3 induction after the 6-h time point, with constant increase up to 24 h
cellular iron levels robustly regulate 13 polyamine pathway proteins. Four proteins are down-regulated (i.e., acireductone dioxygenase 1, methionine adenosyltransferase 2alpha, antizyme and polyamine oxidase) and three proteins are up-regulated (i.e., S-adenosyl methionine decarboxylase, antizyme inhibitor 1 and spermidine/spermine-N1-acetyltransferase 1). Depletion of iron also markedly decreases polyamine pools, (i.e., spermidine and/or spermine, but not putrescine)
-
expression is down-regulated by dehydration stress
expression is up-regulated by thermospermine treatment
expression of the enzyme OsPAO1 appears to be quite low under physiological conditions, but is markedly induced in rice roots by spermine or thermospermine treatment
isoforms PAO1 and PAO2 genes are transcriptionally up-regulated in plants infected by Pseudomonas syringae
NO3- induced AtPAO2::GUS expression is quenched by the presence of NH4+ in the growth medium and abscisic acid-induced AtPAO2::GUS expression is more prominent when the plants are grown on NO3- as the only N source. PAO2OX (an AtPAO2 over-expressing transgenic line) is partially unresponsive to abscisic acid in some growth conditions depending on N-source, pao2 mutants being often more sensitive to abscisic acid than the similarly grown WT
NO3- induced AtPAO2::GUS expression is quenched by the presence of NH4+ in the growth medium and abscisic acid-induced AtPAO2::GUS expression was more prominent when the plants are grown on NO3- as the only N source
positive regulation of AtPAO5 expression by polyamines at the transcriptional and post-transcriptional level
the peptide derived from the AtPAO2 uORF is necessary for translational regulation of the AtPAO2 mORF