1.5.3.4: N6-methyl-lysine oxidase

This is an abbreviated version!
For detailed information about N6-methyl-lysine oxidase, go to the full flat file.

Reaction

N6-methyl-L-lysine
+
H2O
+
O2
=
L-lysine
+
formaldehyde
+
H2O2

Synonyms

epsilon-alkyl-L-lysine:oxygen oxidoreductase, epsilon-alkyllysinase, epsilon-N-methyllysine demethylase, More, N6-methyllysine oxidase, oxidase, N6-methyllysine

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.3 With oxygen as acceptor
                1.5.3.4 N6-methyl-lysine oxidase

Substrates Products

Substrates Products on EC 1.5.3.4 - N6-methyl-lysine oxidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
6-(methylamino)-2-oxohexanoic acid + H2O + O2
6-amino-2-oxohexanoic acid + formaldehyde + H2O2
show the reaction diagram
epsilon-N-methyl groups in protein-bound methyllysine residues + O2 + H2O
demethylated lysine residues + formaldehyde + H2O2
show the reaction diagram
N6,N6-dimethyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
show the reaction diagram
N6-ethyl-L-lysine + H2O + O2
L-lysine + acetaldehyde + H2O2
show the reaction diagram
-
about 50% of the activity with N6-methyl-L-lysine
-
-
?
N6-methyl-D-lysine + H2O + O2
D-lysine + formaldehyde + H2O2
show the reaction diagram
-
11% of the activity with epsilon-N-methyl-L-lysine
-
-
?
N6-methyl-L-lysine + O2 + H2O
L-lysine + formaldehyde + H2O2
show the reaction diagram
N6-methyl-L-lysyl-histone + O2 + H2O
histone + formaldehyde + H2O2
show the reaction diagram
-
-
-
-
?
additional information
?
-