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1.5.99.14: 6-hydroxypseudooxynicotine dehydrogenase

This is an abbreviated version!
For detailed information about 6-hydroxypseudooxynicotine dehydrogenase, go to the full flat file.

Reaction

1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one
+
acceptor
 +
H2O
=
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one
 +
reduced acceptor

Synonyms

KdhA, KdhB, KdhC, KdhL, KdhM, KdhS, PNO

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.99 With unknown physiological acceptors
                1.5.99.14 6-hydroxypseudooxynicotine dehydrogenase

Engineering

Engineering on EC 1.5.99.14 - 6-hydroxypseudooxynicotine dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E345A
mutation in subunit KdhL, inactive
E748A
mutation in subunit KdhL, inactive
F269A
mutation in subunit KdhL, 8fold decrease in catalytic efficiency
R383A
mutation in subunit KdhL, 2fold decrease in catalytic efficiency
W551A
mutation in subunit KdhL, inactive