1.5.99.4: nicotine dehydrogenase

This is an abbreviated version!
For detailed information about nicotine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.99.4

Reaction

(S)-nicotine
+
acceptor
+
H2O
=
(S)-6-hydroxynicotine
+
reduced acceptor

Synonyms

6-hydroxy-D-nicotine oxidase, 6-hydroxy-L-nicotine oxidase, D-nicotine oxidase, NctA, NDH, NdhAB, nicotine dehydrogenase, nicotine oxidase, nicotinic acid hydroxylase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.99 With unknown physiological acceptors
                1.5.99.4 nicotine dehydrogenase

Natural Substrates Products

Natural Substrates Products on EC 1.5.99.4 - nicotine dehydrogenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-nicotine + acceptor + H2O
(R)-6-hydroxynicotine + reduced acceptor
show the reaction diagram
-
-
-
?
(S)-nicotine + acceptor + H2O
pseudooxynicotine + reduced acceptor
show the reaction diagram
D-nicotine + acceptor + H2O
(R)-6-hydroxynicotine + reduced acceptor
show the reaction diagram
isozyme specific for the D-isomer
-
-
?
DL-nicotine + ?
6-hydroxynicotine + ?
show the reaction diagram
-
first enzyme in nicotine pathway
-
?
L-nicotine + acceptor + H2O
(S)-6-hydroxynicotine + reduced acceptor
show the reaction diagram
isozyme strictly specific for the L-isomer
-
-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
show the reaction diagram
nornicotine + acceptor + H2O
6-hydroxynornicotine + reduced acceptor
show the reaction diagram
-
-
-
?
additional information
?
-