1.5.99.4: nicotine dehydrogenase
This is an abbreviated version!
For detailed information about nicotine dehydrogenase, go to the full flat file.
Word Map on EC 1.5.99.4
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1.5.99.4
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arthrobacter
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molybdopterins
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barkeri
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nicotinovorans
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molybdenum
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xanthine
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6-hydroxynicotine
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selenium-containing
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selenocysteine
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molybdenum-containing
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selenoproteins
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selenide
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nicotine-degrading
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6-hydroxy-l-nicotine
- 1.5.99.4
- arthrobacter
- molybdopterins
- barkeri
- nicotinovorans
- molybdenum
- xanthine
- 6-hydroxynicotine
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selenium-containing
- selenocysteine
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molybdenum-containing
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selenoproteins
- selenide
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nicotine-degrading
- 6-hydroxy-l-nicotine
Reaction
Synonyms
6-hydroxy-D-nicotine oxidase, 6-hydroxy-L-nicotine oxidase, D-nicotine oxidase, NctA, NDH, NdhAB, nicotine dehydrogenase, nicotine oxidase, nicotinic acid hydroxylase
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Natural Substrates Products on EC 1.5.99.4 - nicotine dehydrogenase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-nicotine + acceptor + H2O
(R)-6-hydroxynicotine + reduced acceptor
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-
-
?
D-nicotine + acceptor + H2O
(R)-6-hydroxynicotine + reduced acceptor
isozyme specific for the D-isomer
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-
?
DL-nicotine + ?
6-hydroxynicotine + ?
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first enzyme in nicotine pathway
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?
L-nicotine + acceptor + H2O
(S)-6-hydroxynicotine + reduced acceptor
isozyme strictly specific for the L-isomer
-
-
?
nornicotine + acceptor + H2O
6-hydroxynornicotine + reduced acceptor
-
-
-
?
(S)-nicotine + acceptor + H2O
pseudooxynicotine + reduced acceptor
via N-methylmyosmine, which then spontaneously hydrolyzes to pseudooxynicotine. The two enantiomers are degraded at approximately the same rate, indicating that NOX does not show chiral selectivity
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-
?
(S)-nicotine + acceptor + H2O
pseudooxynicotine + reduced acceptor
via N-methylmyosmine, which then spontaneously hydrolyzes to pseudooxynicotine. The two enantiomers are degraded at approximately the same rate, indicating that NOX does not show chiral selectivity
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-
?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
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first enzyme in the nicotine degradation pathway
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?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
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first enzyme in the nicotine degradation pathway
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?
nicotine + acceptor + H2O
6-hydroxynicotine + reduced acceptor
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-
-
?
additional information
?
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enzyme expression and activity is regulated by substrate and product level via transcription repressor HdnoR
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-
?
additional information
?
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enzyme expression and activity is regulated by substrate and product level via transcription repressor HdnoR
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-
?
additional information
?
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enzyme expression and activity is regulated by substrate and product level via transcription repressor HdnoR
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-
?
additional information
?
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organism can grow on L-nicotine since it is converted to D-nicotine by a racemase
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-
?
additional information
?
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organism can grow on L-nicotine since it is converted to D-nicotine by a racemase
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-
?
additional information
?
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organism can grow on L-nicotine since it is converted to D-nicotine by a racemase
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-
?
