1.5.99.4: nicotine dehydrogenase

This is an abbreviated version!
For detailed information about nicotine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.99.4

Reaction

(S)-nicotine
+
acceptor
+
H2O
=
(S)-6-hydroxynicotine
+
reduced acceptor

Synonyms

6-hydroxy-D-nicotine oxidase, 6-hydroxy-L-nicotine oxidase, D-nicotine oxidase, NctA, NDH, NdhAB, nicotine dehydrogenase, nicotine oxidase, nicotinic acid hydroxylase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.99 With unknown physiological acceptors
                1.5.99.4 nicotine dehydrogenase

Specific Activity

Specific Activity on EC 1.5.99.4 - nicotine dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000514 - 0.000888
-
variation caused by pre-treatment with 3-methylcholanthrene, beta-naphthoflavone or phenobarbital
0.0065
-
respiratory microsomes
0.0222
-
olfactory microsomes
1096
-
reduction of 2,6-dichlorophenolindophenol
additional information
-
0.119 units per mg protein, unit is defined as the amount causing a decrease in absorbancy at 578 nm of 0.001 per min