1.6.1.4: NAD(P)+ transhydrogenase (ferredoxin)
This is an abbreviated version!
For detailed information about NAD(P)+ transhydrogenase (ferredoxin), go to the full flat file.
Reaction
+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster = + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster
Synonyms
ferredoxin: NAD(P)H oxidoreductase, ferredoxin:NADP+ oxidoreductase, FprA, NADH-dependent ferredoxin NADP+ oxidoreductase I, NADH-dependent reduced ferredoxin:NADP oxidoreductase, NADH-dependent reduced ferredoxin:NADP+ oxidoreductase, NADPH:ferredoxin oxidoreductase, Nfn1, NfnAB, NfnI, PF1327-28, PntAB
ECTree
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Cofactor
Cofactor on EC 1.6.1.4 - NAD(P)+ transhydrogenase (ferredoxin)
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[2Fe-2S]-center
the 31000 Da subunit contains one FAD (S-FAD) and a [2Fe-2S] cluster. The [2Fe-2S] cluster is unusual, with a relatively high (positive) reduction potential and coordination by one Asp and three Cys ligands
[4Fe-4S]-center
the 53000 Da subunit contains one FAD (L-FAD), which is the site of electron bifurcation, and two [4Fe-4S] clusters
FAD
A5N5D2; A5N5D3
iron-sulfur flavoprotein complex. Subunit NfnB contains FAD
FAD
the 31000 Da subunit contains one FAD (S-FAD) and a [2Fe-2S] cluster with an unusual Asp ligand. The 53000 Da subunit contains one FAD (L-FAD), which is the site of electron bifurcation, and two [4Fe-4S] clusters. The L-FAD proximal [4Fe-4S] cluster coordination includes an unusual Glu ligand. S-FAD and L-FAD bind NADH and NADPH, respectively
iron-sulfur centre
A5N5D2; A5N5D3
iron-sulfur flavoprotein complex, subunit NfnA has a predicted [2Fe2S] binding site, subunit NfnB has two predicted [4Fe4S] binding sites. UV-visible spectrum shows that the NfnAB complex contains up to 10 Fe molecules per heterodimer, which is consistent with the presence of two [4Fe4S] and one [2Fe2S] clusters