1.6.1.4: NAD(P)+ transhydrogenase (ferredoxin)
This is an abbreviated version!
For detailed information about NAD(P)+ transhydrogenase (ferredoxin), go to the full flat file.
Reaction
Synonyms
ferredoxin: NAD(P)H oxidoreductase, ferredoxin:NADP+ oxidoreductase, FprA, NADH-dependent ferredoxin NADP+ oxidoreductase I, NADH-dependent reduced ferredoxin:NADP oxidoreductase, NADH-dependent reduced ferredoxin:NADP+ oxidoreductase, NADPH:ferredoxin oxidoreductase, Nfn1, NfnAB, NfnI, PF1327-28, PntAB
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1.6.1.4 NAD(P)+ transhydrogenase (ferredoxin)Advanced search results
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Substrates Products on EC 1.6.1.4 - NAD(P)+ transhydrogenase (ferredoxin)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NAD+ + 2 NADPH + 2 oxidized ferredoxin iron-sulfur cluster
NADH + H+ + 2 NADP+ + reduced ferredoxin iron-sulfur cluster
NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster
reduction of both NAD+ and Fd by Nfn enzymes is coupled to the bifurcation of electrons from NADPH oxidation. The exergonic coupling of the NADP(H) and NAD(H) half reactions in Nfn is presumed to be mediated by NADPH oxidation at L-FAD followed by electron transfer to the proximal [2Fe-2S] cluster and subsequently the NAD(H) binding site at S-FAD. Biophysical analysis of the enzyme provides the first direct insight into the mechanism of flavin-based electron bifurcation and the requisite structural features
-
-
?
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin iron-sulfur cluster
NAD+ + 2 NADPH + 2 oxidized ferredoxin iron-sulfur cluster
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin iron-sulfur cluster
NAD+ + 2 NADPH + 2 reduced ferredoxin iron-sulfur cluster
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster
NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster
NADH + H+ + NADP+ + reduced ferredoxin [iron-sulfur] cluster
NAD+ + NADPH + oxidized ferredoxin [iron-sulfur] cluster
additional information
?
-
-
flavoenzyme, additionally shows NADPH-cytochrome c reductase activity, EC 1.6.2.4
-
-
?
NAD+ + 2 NADPH + 2 oxidized ferredoxin iron-sulfur cluster
NADH + H+ + 2 NADP+ + reduced ferredoxin iron-sulfur cluster
A5N5D2; A5N5D3
in the absence of NAD+, ferredoxin is only very slowly reduced (0.5% of the rate seen in the presence of NAD+). In the absence of ferredoxin, NAD+ is only very slowly reduced (less than 1% of the rate observed in the presence of ferredoxin)
-
-
r
NAD+ + 2 NADPH + 2 oxidized ferredoxin iron-sulfur cluster
NADH + H+ + 2 NADP+ + reduced ferredoxin iron-sulfur cluster
A5N5D2; A5N5D3
in the absence of NAD+, ferredoxin is only very slowly reduced (0.5% of the rate seen in the presence of NAD+). In the absence of ferredoxin, NAD+ is only very slowly reduced (less than 1% of the rate observed in the presence of ferredoxin)
-
-
r
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin iron-sulfur cluster
NAD+ + 2 NADPH + 2 oxidized ferredoxin iron-sulfur cluster
A5N5D2; A5N5D3
the iron-sulfur flavoprotein complex, isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH. In the absence of NAD+, ferredoxin is only very slowly reduced (0.5% of the rate seen in the presence of NAD+)
-
-
r
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin iron-sulfur cluster
NAD+ + 2 NADPH + 2 oxidized ferredoxin iron-sulfur cluster
A5N5D2; A5N5D3
the iron-sulfur flavoprotein complex, isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH. In the absence of NAD+, ferredoxin is only very slowly reduced (0.5% of the rate seen in the presence of NAD+)
-
-
r
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin iron-sulfur cluster
NAD+ + 2 NADPH + 2 reduced ferredoxin iron-sulfur cluster
A5N5D2; A5N5D3
the iron-sulfur flavoprotein complex, isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH
-
-
r
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin iron-sulfur cluster
NAD+ + 2 NADPH + 2 reduced ferredoxin iron-sulfur cluster
A5N5D2; A5N5D3
the iron-sulfur flavoprotein complex, isolated from the bacterium Clostridium kluyveri, couples the exergonic reduction of NADP+ with reduced ferredoxin and the endergonic reduction of NADP+ with NADH
-
-
r
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster
NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster
-
-
0.064 mol of NAD + is reduced per mol of enzyme per s with NADPH produced continuously by glucose-6-phosphate dehydrogenase system
-
?
NADH + H+ + 2 NADP+ + 2 reduced ferredoxin [iron-sulfur] cluster
NAD+ + 2 NADPH + 2 oxidized ferredoxin [iron-sulfur] cluster
-
-
-
?
NADH + H+ + NADP+ + reduced ferredoxin [iron-sulfur] cluster
NAD+ + NADPH + oxidized ferredoxin [iron-sulfur] cluster
-
-
-
-
?
NADH + H+ + NADP+ + reduced ferredoxin [iron-sulfur] cluster
NAD+ + NADPH + oxidized ferredoxin [iron-sulfur] cluster
-
-
-
-
?
NADH + H+ + NADP+ + reduced ferredoxin [iron-sulfur] cluster
NAD+ + NADPH + oxidized ferredoxin [iron-sulfur] cluster
-
-
-
-
?
NADH + H+ + NADP+ + reduced ferredoxin [iron-sulfur] cluster
NAD+ + NADPH + oxidized ferredoxin [iron-sulfur] cluster
-
-
-
-
?
NADH + H+ + NADP+ + reduced ferredoxin [iron-sulfur] cluster
NAD+ + NADPH + oxidized ferredoxin [iron-sulfur] cluster
-
-
-
?
NADH + H+ + NADP+ + reduced ferredoxin [iron-sulfur] cluster
NAD+ + NADPH + oxidized ferredoxin [iron-sulfur] cluster
-
-
-
?
