1.6.2.2: cytochrome-b5 reductase

This is an abbreviated version!
For detailed information about cytochrome-b5 reductase, go to the full flat file.

Reaction

Synonyms

b5 plus
b5R, b5/b5R, B5R, cb5r, CBR, CBR1, CBR1A, CBR1B, CyB5R, CYB5R2, CYB5R3, Cyb5R4, cyt b5r, cyt b5R protein, cytochrome b5 reductase, cytochrome b5 reductase 2, cytochrome b5 reductase 3, DIA1, diaphorase I, dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase, HPO-19, methemoglobin reductase, NADH cytochrome b5 oxidoreductase, NADH cytochrome B5 reductase, NADH-b5R, NADH-cytochrome b 5 reductase, NADH-cytochrome b5 reductase, NADH-cytochrome b5 reductase 3, NADH-cytochrome-b5 reductase, NADH-cytochrome-b5 reductase 3, NADH-dependent cytochrome b5 reductase, NADH-ferricyanide reductase, NADH-ferricytochrome b5 oxidoreductase, NADH-ferricytochrome reductase, NADH: ferricytochrome b5 oxidoreductase, NADH:cytochrome b5 reductase, NADH:ferricytochrome b5 oxidoreductase, Ncb5or, P34/P32, P35, reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase, reductase, cytochrome b5, T05H4.4

ECTree

     1 Oxidoreductases

         1.6 Acting on NADH or NADPH

             1.6.2 With a heme protein as acceptor

                1.6.2.2 cytochrome-b5 reductase

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Results	in table
4	Activating Compound
9501	AA Sequence
13	Application
1	CAS Registry Number
37	Cloned(Commentary)
143	Cofactor
13	Crystallization (Commentary)
772	Disease/ Diagnostics
3	Expression
36	General Information
13	General Stability
15	IC50 Value
118	Inhibitors
23	kcat/KM [mM/s]
5	Ki Value [mM]
302	KM Value [mM]
111	Localization
9	Metals/Ions
50	Molecular Weight [Da]
75	Natural Substrates/ Products (Substrates)
170	Organism
1	Oxidation Stability
1	Pathway
21	PDB ID
27	pH Optimum
2	pH Range
2	pH Stability
1	pI Value
5	Posttranslational Modification
117	Protein Variants
60	Purification (Commentary)
9	Reaction
3	Reaction Type
167	Reference
1	Renatured (Commentary)
126	Source Tissue
44	Specific Activity [micromol/min/mg]
13	Storage Stability
246	Substrates and Products (Substrate)
41	Subunits
129	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
7	Temperature Stability [°C]
224	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.6.2.2 - cytochrome-b5 reductase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0045

(+)-catechin

Bos taurus

-

pH 7.5, 22°C

724717

0.0098

(+)-taxifolin

Bos taurus

-

pH 7.5, 24-25°C

726519

0.0032

(-)-epicatechin

Bos taurus

-

pH 7.5, 22°C

724717

0.00914

6-([[(2R)-2,3-dihydro-1,3-benzoxazol-2-yl]sulfanyl]methyl)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one

Homo sapiens

P00387

at pH 7.5 and 37°C

742875

0.0108

6-[(phenylsulfanyl)methyl]-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one

Homo sapiens

P00387

at pH 7.5 and 37°C

742875

0.036

apigenin

Bos taurus

-

pH 7.5, 22°C

724717

0.00011

luteolin

Bos taurus

-

pH 7.5, 22°C

724717

0.0024

luteolin-7-O-glucoside

Bos taurus

-

pH 7.5, 22°C

724717

0.00081

morin

Bos taurus

-

pH 7.5, 22°C

724717

0.00037 - 0.0015

myricetin

2 entries

0.2794

propylthiouracil

Homo sapiens

P00387

at pH 7.5 and 37°C

742875

0.0011

quercetin

Bos taurus

-

pH 7.5, 22°C

724717

0.0012

quercitrin

Bos taurus

-

pH 7.5, 22°C

724717

0.057

rutin

Bos taurus

-

pH 7.5, 22°C

724717

0.00037

myricetin

Bos taurus

-

pH 7.5, 24-25°C

726519

0.0015

myricetin

Bos taurus

-

pH 7.5, 22°C

724717