1.6.2.4: NADPH-hemoprotein reductase

This is an abbreviated version!
For detailed information about NADPH-hemoprotein reductase, go to the full flat file.

Word Map on EC 1.6.2.4

Reaction

NADPH
+
H+
+ n oxidized hemoprotein =
NADP+
+ n reduced hemoprotein

Synonyms

aldehyde reductase (NADPH-dependent), ATR2, CPR, CPR I, CPR-X1, CPR-X2, CPR1, CPR2, CYPOR, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), cytochrome P450 NADPH reductase, cytochrome P450 oxidoreductase, cytochrome P450 reductase, cytochrome P450-diflavin reductase, dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, EC 1.6.99.2, FAD-cytochrome c reductase, ferrihemprotein P450 reductase, flavocytochrome P450 BM3, NAD(P)H cytochrome P450 reductase, NADP-cytochrome c reductase, NADP-cytochrome P-450 reductase, NADP-cytochrome reductase, NADPH cytochrome P450 reductase, NADPH dependent cytochrome P450 reductase, NADPH P450 oxidoreductase, NADPH P450 reductase, NADPH-CPR, NADPH-CYP reductase, NADPH-CYP450 reductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH-cytochrome p-450 reductase, NADPH-cytochrome P450 (CYP) oxidoreductase, NADPH-cytochrome P450 oxidoreductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome P450 reductase 2, NADPH-dependent cytochrome c reductase, NADPH-dependent cytochrome P450 reductase, NADPH-dependent P450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, NADPH-P450 reductase, NADPH: cytochrome P450 oxidoreductase, NADPH: cytochrome P450 reductase, NADPH:CYP oxidoreductase, NADPH:cytochrome P450 oxidoreductase, NADPH:cytochrome P450 reductase, NADPH:ferrihemoprotein oxidoreductase, neotetrazolin reductase, NPR, P-450 reductase, P450 BM3, P450 oxidoreductase, P450 Red, P450 reductase, P450R, P450REd, POR, RedA, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate), SbCPR2, TcCPR-A, TcCPR-B, TcCPR-C, TPNH-cytochrome c reductase, TPNH2 cytochrome c reductase, WsCPR1, WsCPR2

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.2 With a heme protein as acceptor
                1.6.2.4 NADPH-hemoprotein reductase

Expression

Expression on EC 1.6.2.4 - NADPH-hemoprotein reductase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
all-trans-retinoic acid treatment upregulates the enzyme expression
-
at the red ripe stage, the expression level of isoform CPR1 is more than 6fold greater than that in leaves or flowers
enzyme expression is induced by low concentrations of isoprocarb and imidacloprid
enzyme expression is up-regulated and more inducible with fenpropathrin treatment in the fenpropathrin-resistant strain compared with the susceptible SS strain
enzyme xpression is inducible by UV-B and phytohormone elicitation
exposure of males to a plant odorant down-regulates the transcript level of CPR
-
expression of isozyme CPR2, but not CPR1, is inducible by mechanical wounding and elicitation. Isozyme CPR1 is expressed at a relatively constant level throughout the developmental stages investigated (0-40 days post anthesis), with a slight up-regulation at 15 days post anthesis
isozyme CPR2 shows a dramatic increase of transcript abundance around 15-20 days post anthesis
the enzyme expression level is enhanced by beta-cypermethrin at the concentration of 12 mg/l
-
the enzyme in acute myeloid leukemia cells is upregulated by all-trans-retinoic acid and by 1,25-dihydroxyvitamin D3 at the level of mRNA and protein
-
the expression level of mRNA is 1.84fold higher in midgut of 5th instars of the Handan susceptible strain than that in pupae, and the level in themidgut of handan fenvalerate resistant strain is 2.02fold higher than that of the Handan susceptible strain. The levels of mRNA are induced by phenobarbital at concentrations of 2 and 4 mg/g, which enhances 5.20 and 17.45fold, respectively, compared to that of the control after 48 h of phenobarbital treatment
the mRNA level decreases remarkably after exposure to quercetin and tannin
WsCPR1 is uninducible while WsCPR2 transcript level increase in a time-dependent manner after elicitor treatments, e.g. by methyljasmonate or salicylic acid