1.6.2.4: NADPH-hemoprotein reductase

This is an abbreviated version!
For detailed information about NADPH-hemoprotein reductase, go to the full flat file.

Word Map on EC 1.6.2.4

Reaction

NADPH
+
H+
+ n oxidized hemoprotein =
NADP+
+ n reduced hemoprotein

Synonyms

aldehyde reductase (NADPH-dependent), ATR2, CPR, CPR I, CPR-X1, CPR-X2, CPR1, CPR2, CYPOR, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), cytochrome P450 NADPH reductase, cytochrome P450 oxidoreductase, cytochrome P450 reductase, cytochrome P450-diflavin reductase, dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, EC 1.6.99.2, FAD-cytochrome c reductase, ferrihemprotein P450 reductase, flavocytochrome P450 BM3, NAD(P)H cytochrome P450 reductase, NADP-cytochrome c reductase, NADP-cytochrome P-450 reductase, NADP-cytochrome reductase, NADPH cytochrome P450 reductase, NADPH dependent cytochrome P450 reductase, NADPH P450 oxidoreductase, NADPH P450 reductase, NADPH-CPR, NADPH-CYP reductase, NADPH-CYP450 reductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH-cytochrome p-450 reductase, NADPH-cytochrome P450 (CYP) oxidoreductase, NADPH-cytochrome P450 oxidoreductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome P450 reductase 2, NADPH-dependent cytochrome c reductase, NADPH-dependent cytochrome P450 reductase, NADPH-dependent P450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, NADPH-P450 reductase, NADPH: cytochrome P450 oxidoreductase, NADPH: cytochrome P450 reductase, NADPH:CYP oxidoreductase, NADPH:cytochrome P450 oxidoreductase, NADPH:cytochrome P450 reductase, NADPH:ferrihemoprotein oxidoreductase, neotetrazolin reductase, NPR, P-450 reductase, P450 BM3, P450 oxidoreductase, P450 Red, P450 reductase, P450R, P450REd, POR, RedA, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate), SbCPR2, TcCPR-A, TcCPR-B, TcCPR-C, TPNH-cytochrome c reductase, TPNH2 cytochrome c reductase, WsCPR1, WsCPR2

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.2 With a heme protein as acceptor
                1.6.2.4 NADPH-hemoprotein reductase

Inhibitors

Inhibitors on EC 1.6.2.4 - NADPH-hemoprotein reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2',5'-ADP
2'-AMP
2,6-dichlorophenolindophenol
-
formation of superoxide anion, in the presence of menadione
2-chloroethyl ethyl sulfide
3-((3-cholamidopropyl)dimethylammonio)propanesulfonic acid
-
-
3-Aminonicotinamide adenine dinucleotide phosphate
-
-
4-phenylimidazole
inhibitory azole ligand that co-ordinates the haem iron in the sixth (axial) position
5,5'-dithiobis(2-nitrobenzoate)
-
in absence of FAD or NADPH
6-Propyl-2-thiouracil
-
-
Ag+
-
competitive inhibition
AlCl3
-
noncompetitive inhibitor, inhibitory effects of Al3+ and Tl3+ on purified cytochrome P450 reductase are partially recovered by 1 mM EDTA
alpha-lipoic acid
Cd2+
-
0.05 mM, 66% inhibition. IC50: 0.024 mM, noncompetitive inhibition; 0.05 mM, 66% inhibition, noncompetitive
cetyltrimethyl ammonium bromide
-
-
Cr3+
-
0.05 mM,65% inhibition. IC50: 0.033 mM, noncompetitive inhibition; 0.05 mM, 65% inhibition, noncompetitive
Cu2+
-
competitive inhibition
diphenylene iodonium sulfate
-
time-dependent and concentration-dependent inhibition of cDNA-expressed liver enzyme as well as aortic and hepatic microsomal enzyme activity
diphenyleneiodonium
EDTA
-
reduction of cytochrome c and formation of superoxide anion
Ethacrynic acid
-
64% inhibition at 1.0 mM
HgCl2
Lubrol WX
-
-
-
menadione
-
85% inhibition at 0.2 mM
Mersalyl
N-ethylmaleimide
-
reduction of cytochrome c and formation of superoxide anion
Ni2+
-
0.05 mM, 37% inhibition. IC50: 0.143 mM, noncompetitive inhibition; 0.05 mM, 37% inhibition, noncompetitive
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
presence of mercaptoethanol or NADPH provides slight protection against inhibition
phenolphthaleine
-
13% inhibition at 0.02 mM
-
quercetin
steapsin
-
brain
-
Tannic acid
TlCl3
-
noncompetitive inhibitor, inhibitory effects of Al3+ and Tl3+ on purified cytochrome P450 reductase are partially recovered by 1 mM EDTA
Triton N-101
-
-
-
additional information
-