1.6.2.4: NADPH-hemoprotein reductase
This is an abbreviated version!
For detailed information about NADPH-hemoprotein reductase, go to the full flat file.
Word Map on EC 1.6.2.4
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1.6.2.4
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monooxygenase
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heme
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quinone
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xenobiotics
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fmn
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1.6.99.2
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flavoproteins
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dt-diaphorase
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phenobarbital
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cyp3a4
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benzoapyrene
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nadph:quinone
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one-electron
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drug-metabolizing
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bioreductive
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7-ethoxycoumarin
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semiquinone
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benzphetamine
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two-electron
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nadh-cytochrome
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aminopyrine
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cyp2c9
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21-hydroxylase
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n-demethylase
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o-deethylation
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phenobarbital-induced
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p-450-dependent
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3-methylcholanthrene
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androstenedione
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adrenodoxin
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dicoumarol
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7-ethoxyresorufin
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ethylmorphine
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phenobarbital-treated
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beta-naphthoflavone
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mixed-function
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p-nitroanisole
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p450-mediated
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nitroreduction
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p450-catalyzed
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7,8-benzoflavone
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omega-hydroxylation
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cyp21a2
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chlorzoxazone
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o-dealkylation
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virilization
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17alpha-hydroxylase
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6beta-hydroxylation
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biotechnology
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medicine
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bufuralol
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2-amino-3-methylimidazo4,5-fquinoline
- 1.6.2.4
- monooxygenase
- heme
- quinone
- xenobiotics
- fmn
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1.6.99.2
- flavoproteins
- dt-diaphorase
- phenobarbital
- cyp3a4
-
benzoapyrene
-
nadph:quinone
-
one-electron
-
drug-metabolizing
-
bioreductive
- 7-ethoxycoumarin
- semiquinone
- benzphetamine
-
two-electron
-
nadh-cytochrome
- aminopyrine
- cyp2c9
- 21-hydroxylase
- n-demethylase
-
o-deethylation
-
phenobarbital-induced
-
p-450-dependent
- 3-methylcholanthrene
- androstenedione
- adrenodoxin
- dicoumarol
- 7-ethoxyresorufin
- ethylmorphine
-
phenobarbital-treated
- beta-naphthoflavone
-
mixed-function
-
p-nitroanisole
-
p450-mediated
-
nitroreduction
-
p450-catalyzed
- 7,8-benzoflavone
-
omega-hydroxylation
- cyp21a2
- chlorzoxazone
-
o-dealkylation
-
virilization
- 17alpha-hydroxylase
-
6beta-hydroxylation
- biotechnology
- medicine
- bufuralol
-
2-amino-3-methylimidazo4,5-fquinoline
Reaction
Synonyms
107366505, aldehyde reductase (NADPH-dependent), ATR2, CPR, CPR I, CPR-X1, CPR-X2, CPR1, CPR2, CYPOR, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), cytochrome P450 NADPH reductase, cytochrome P450 oxidoreductase, cytochrome P450 reductase, cytochrome P450-diflavin reductase, dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, FAD-cytochrome c reductase, ferrihemprotein P450 reductase, flavocytochrome P450 BM3, NAD(P)H cytochrome P450 reductase, NADP-cytochrome c reductase, NADP-cytochrome P-450 reductase, NADP-cytochrome reductase, NADPH cytochrome P450 reductase, NADPH dependent cytochrome P450 reductase, NADPH P450 oxidoreductase, NADPH P450 reductase, NADPH-CPR, NADPH-CYP reductase, NADPH-CYP450 reductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH-cytochrome p-450 reductase, NADPH-cytochrome P450 (CYP) oxidoreductase, NADPH-cytochrome P450 oxidoreductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome P450 reductase 2, NADPH-dependent cytochrome c reductase, NADPH-dependent cytochrome P450 reductase, NADPH-dependent P450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, NADPH-P450 reductase, NADPH: cytochrome P450 oxidoreductase, NADPH: cytochrome P450 reductase, NADPH:CYP oxidoreductase, NADPH:cytochrome P450 oxidoreductase, NADPH:cytochrome P450 reductase, NADPH:ferrihemoprotein oxidoreductase, NCP1, neotetrazolin reductase, NPR, NP_000932, P-450 reductase, P450 BM3, P450 oxidoreductase, P450 Red, P450 reductase, P450R, P450REd, POR, RedA, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate), SbCPR2, TcCPR-A, TcCPR-B, TcCPR-C, TPNH-cytochrome c reductase, TPNH2 cytochrome c reductase, WsCPR1, WsCPR2
ECTree
1.6.2.4 NADPH-hemoprotein reductaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 1.6.2.4 - NADPH-hemoprotein reductase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity
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cement gland, lens placode, ear vesicle, mesencephalon, rhombencephalon, lymphatic vessel and heart anlage at stage 29
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the highest level of CPR expression is found in mature leaves followed by flowers, young leaves, rhizomes, and stems
additional information
overexpression of TcCPR-B in Trypanosoma cruzi epimastigotes increases its resistance to the typical chemotherapeutic agents Nifurtimox and Benznidazole
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the highest level of CPR expression is found in mature leaves followed by flowers, young leaves, rhizomes, and stems
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the highest level of CPR expression is found in mature leaves followed by flowers, young leaves, rhizomes, and stems
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hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase
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liver POR plays an important role regulating gene expression and lipid metabolism locally. The hepatic deficiency of this enzyme reverberates throughout the biological system and produces a coordinated response to the low levels of circulating cholesterol and bile
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288550, 288571, 288575, 288577, 288580, 288585, 288587, 288590, 288602, 288616, 288619, 438257, 671712, 674672, 686851, 713542, 742564
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phenobarbital-treated animals
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the numbers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumors are reduced in the lung-Cpr-null mice but are increased in the liver-Cpr-null mice, relative to wild-type control mice
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the highest level of CPR expression is found in mature leaves followed by flowers, young leaves, rhizomes, and stems
additional information
tissue- and developmental stage-dependent expression analysis of CsCPR mRNA by real-time quantitative PCR. The enzyme is exxpressed in the digestive, metabolic, and olfactory organs of the larvae and adults, overview
additional information
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CPR activity in 28-day-old male offspring in only the LM76 group (low protein diet based on the modified version of the AIN76A purified diet) but not in the L93 group (low protein diet based on the AIN93G purified diet) is significantly greater than its purified control. CPR activity in 28-day-old male offspring of the M76 group is lower than that in the NP group (nonpurified diet). CPR activities in 65- and 150-day-old male offspring in all five groups are similar. CPR activities in 28-day-old female offspring of the LPD groups are similar to those of their respective purified control groups. However, CPR activities in 28-day-old female offspring in both the purified control groups are lower than that in the NP group. These differences disappeare by day 65, and the lack of differences persisted on day 150. Gender differences (activity in males greater than that in females) are present in all five groups on day 150 but not on days 28 and 65 (the 28-day-old NP group being an exception)
additional information
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P450 enzyme expression patterns in adult and larval tissues, overview
additional information
protein is detected in all tested developmental stages and tissues, but highly expressed in third-, fourth-, and fifth-instar larvae, and in midgut and fat body
additional information
CPR is ubiquitously transcribed in different life stages of Tetranychus urticae, the highest transcription is observed in the nymph and adult stages
additional information
presence in every Trypanosoma cruzi developmental stage
additional information
presence in every Trypanosoma cruzi developmental stage
additional information
presence in every Trypanosoma cruzi developmental stage
additional information
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presence in every Trypanosoma cruzi developmental stage
additional information
higher expression level of WsCPR2 in comparison to WsCPR1
additional information
higher expression level of WsCPR2 in comparison to WsCPR1
additional information
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higher expression level of WsCPR2 in comparison to WsCPR1
