1.6.2.4: NADPH-hemoprotein reductase

This is an abbreviated version!
For detailed information about NADPH-hemoprotein reductase, go to the full flat file.

Word Map on EC 1.6.2.4

Reaction

NADPH
+
H+
+ n oxidized hemoprotein =
NADP+
+ n reduced hemoprotein

Synonyms

aldehyde reductase (NADPH-dependent), ATR2, CPR, CPR I, CPR-X1, CPR-X2, CPR1, CPR2, CYPOR, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), cytochrome P450 NADPH reductase, cytochrome P450 oxidoreductase, cytochrome P450 reductase, cytochrome P450-diflavin reductase, dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, EC 1.6.99.2, FAD-cytochrome c reductase, ferrihemprotein P450 reductase, flavocytochrome P450 BM3, NAD(P)H cytochrome P450 reductase, NADP-cytochrome c reductase, NADP-cytochrome P-450 reductase, NADP-cytochrome reductase, NADPH cytochrome P450 reductase, NADPH dependent cytochrome P450 reductase, NADPH P450 oxidoreductase, NADPH P450 reductase, NADPH-CPR, NADPH-CYP reductase, NADPH-CYP450 reductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH-cytochrome p-450 reductase, NADPH-cytochrome P450 (CYP) oxidoreductase, NADPH-cytochrome P450 oxidoreductase, NADPH-cytochrome P450 reductase, NADPH-cytochrome P450 reductase 2, NADPH-dependent cytochrome c reductase, NADPH-dependent cytochrome P450 reductase, NADPH-dependent P450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, NADPH-P450 reductase, NADPH: cytochrome P450 oxidoreductase, NADPH: cytochrome P450 reductase, NADPH:CYP oxidoreductase, NADPH:cytochrome P450 oxidoreductase, NADPH:cytochrome P450 reductase, NADPH:ferrihemoprotein oxidoreductase, neotetrazolin reductase, NPR, P-450 reductase, P450 BM3, P450 oxidoreductase, P450 Red, P450 reductase, P450R, P450REd, POR, RedA, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate), SbCPR2, TcCPR-A, TcCPR-B, TcCPR-C, TPNH-cytochrome c reductase, TPNH2 cytochrome c reductase, WsCPR1, WsCPR2

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.2 With a heme protein as acceptor
                1.6.2.4 NADPH-hemoprotein reductase

Substrates Products

Substrates Products on EC 1.6.2.4 - NADPH-hemoprotein reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 ferricyanide + NADPH
2 ferrocyanide + NADP+ + H+
show the reaction diagram
2 ferricytochrome c + NADH
2 ferrocytochrome c + NAD+ + H+
show the reaction diagram
2 ferricytochrome c + NADPH
2 ferrocytochrome c + NADP+ + H+
show the reaction diagram
2 ferricytochrome P450 + NADPH
2 ferrocytochrome P450 + NADP+ + H+
show the reaction diagram
2 oxidized cytochrome c + NADPH + H+
2 reduced cytochrome c + NADP+
show the reaction diagram
2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone + NADPH
NADP+ + ?
show the reaction diagram
-
i.e. RH1, the enzyme reduces the antitumor drug RH1 to a semiquinone free radical. Following this reduction RH1 undergoes redox cycling under oxic conditions to produce potentially damaging hydroxyl radicals
-
-
?
4-nitroacetophenone + NADPH + H+
?
show the reaction diagram
benzphetamine
?
show the reaction diagram
cocaine
?
show the reaction diagram
ferricyanide + NADPH + H+
ferrocyanide + NADP+
show the reaction diagram
-
-
-
-
r
ferricytochrome c + azidonitrophenyl-gamma-aminobutyryl-NADPH + H+
ferrocytochrome c + azidonitrophenyl-gamma-aminobutyryl-NADP+
show the reaction diagram
-
-
-
-
r
ferricytochrome c + dithionite
ferrocytochrome c + ?
show the reaction diagram
ferricytochrome c + NADH + H+
ferrocytochrome c + NAD+
show the reaction diagram
ferricytochrome c + NADPH + H+
ferrocytochrome c + NADP+
show the reaction diagram
NADH + H+ + ferricytochrome c
NAD+ + ferricytochrome c
show the reaction diagram
-
very low activity with NADH
-
-
?
NADH + H+ + ferricytochrome c
NAD+ + ferrocytochrome c
show the reaction diagram
-
-
-
-
r
NADPH + 5-cyano-2,3-di-p-tolyltetrazolium chloride
NADP+ + (5-cyano-2,3-di-p-tolyltetrazolium chloride) formazan
show the reaction diagram
-
-
formazan is fluorescent
-
?
NADPH + ferricytochrome P450
ferrocytochrome P450 + NADP+
show the reaction diagram
NADPH + H+ + 1-[3-(4-phenoxyphenoxy)-2-oxopropyl]indole-5-carboxylic acid
NADP+ + 1-[2-hydroxy-3-(4-phenoxyphenoxy)propyl]indole-5-carboxylic acid
show the reaction diagram
-
-
-
-
?
NADPH + H+ + 2 oxidized cytochrome c
NADP+ + 2 reduced cytochrome c
show the reaction diagram
NADPH + H+ + 2 oxidized cytochrome P450 2B4
NADP+ + 2 reduced cytochrome P450 2B4
show the reaction diagram
-
-
-
?
NADPH + H+ + 2,4,6-trinitrotoluene
NADP+ + nitrite + ?
show the reaction diagram
-
-
-
-
?
NADPH + H+ + 4-nitroacetophenone
?
show the reaction diagram
-
-
-
-
r
NADPH + H+ + 4-nitrobenzaldehyde
?
show the reaction diagram
-
-
-
-
r
NADPH + H+ + 4-nitroso-2,6-dinitrotoluene
NADP+ + 4-hydroxyamino-2,6-dinitrotoluene
show the reaction diagram
-
-
-
-
?
NADPH + H+ + benzalacetone
?
show the reaction diagram
-
-
-
-
r
NADPH + H+ + cytochrome c
NADP+ + reduced cytochrome c
show the reaction diagram
NADPH + H+ + daunorubicin
NADP+ + ?
show the reaction diagram
-
-
-
-
?
NADPH + H+ + dichlorophenolindophenol
NADP+ + reduced dichlorophenolindophenol
show the reaction diagram
-
-
-
?
NADPH + H+ + doxorubicin
NADP+ + 7-deoxydoxorubicinone
show the reaction diagram
-
-
-
?
NADPH + H+ + ferricyanide
NADP+ + ferrocyanide
show the reaction diagram
NADPH + H+ + ferricytochrome b5
NADP+ + ferrocytochrome b5
show the reaction diagram
-
-
-
?
NADPH + H+ + ferricytochrome c
NADP+ + ferrocytochrome c
show the reaction diagram
NADPH + H+ + ferrocytochrome b5
NADP+ + ferricytochrome b5
show the reaction diagram
-
-
-
-
?
NADPH + H+ + haloperidol
NADP+ + ?
show the reaction diagram
-
-
-
-
?
NADPH + H+ + menadione
NADP+ + menadiol
show the reaction diagram
NADPH + H+ + n oxidized hemoprotein
NADP+ + n reduced hemoprotein
show the reaction diagram
NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
NADP+ + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
NADPH + H+ + oxidized 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
NADP+ + reduced 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
show the reaction diagram
NADPH + H+ + oxidized 5-cyano-2,3-ditolyl tetrazolium chloride
NADP+ + reduced 5-cyano-2,3-ditolyl tetrazolium chloride
show the reaction diagram
-
-
-
?
NADPH + H+ + oxidized CYP106A1
NADP+ + reduced CYP106A1
show the reaction diagram
NADPH + H+ + oxidized CYP21A2
NADP+ + reduced CYP21A2
show the reaction diagram
NADPH + H+ + oxidized cytochrome c
NADP+ + reduced cytochrome c
show the reaction diagram
NADPH + H+ + oxidized eburicol
NADP+ + reduced eburicol
show the reaction diagram
-
-
-
-
?
NADPH + H+ + oxidized lanosterol
NADP+ + reduced lanosterol
show the reaction diagram
-
-
-
-
?
NADPH + H+ + oxidized menadione
NADP+ + reduced menadione
show the reaction diagram
NADPH + H+ + oxidized tetrazolium
NADP+ + reduced tetrazolium
show the reaction diagram
-
-
-
?
NADPH + H+ + oxidized thiazolyl blue tetrazolium bromide
NADP+ + reduced thiazolyl blue tetrazolium bromide
show the reaction diagram
NADPH + H+ oxidized 2,6-dichlorophenolindophenol
ferrocytochrome c + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
NADPH + hexadecanal
NADP+ + hexadecanol
show the reaction diagram
-
brain, hexadecanal replaceable by p-nitroacetophenone, or p-pyridinecarboxaldehyde, benzalacetone or p-nitrobenzaldehyde
-
?
NADPH + mitoxanthrone
NADP+ + ?
show the reaction diagram
-
-
-
-
?
NADPH + O2
NADP+ + O2-
show the reaction diagram
NADPH + octanal
NADP+ + octanol
show the reaction diagram
-
-
-
?
paraquat + NADPH
?
show the reaction diagram
-
paraquat is a toxic herbicide
-
-
?
additional information
?
-