1.6.3.1: NAD(P)H oxidase (H2O2-forming)

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For detailed information about NAD(P)H oxidase (H2O2-forming), go to the full flat file.

Reaction

Synonyms

100787949, 100812342, 100820185, Atrbohc, AtrbohD NADPH oxidase, AtrbohF NADPH oxidase, BLI-3, cytochrome b-245 heavy chain, dual oxidase, Duox, Duox-DuoxA NADPH oxidase, Duox1, Duox2, Glyma.03G236300, Glyma.19G233900, Glyma.20G236200, GLYMA_10G152200, gp91phox, gp91phox/Nox2, KOD1, large NOX, LNOX, NAD(P)H oxidase, NAD(P)H oxidase 4, NADH oxidase, NADPH oxidase, NADPH oxidase 1, NADPH oxidase 2, NADPH oxidase 4, NADPH oxidase 5, NADPH oxidase type 4, NADPH-oxidase, NADPHox, NAPDH oxidase, NM_001184780, NOX, NOX1, Nox2, NOX3, Nox4, NOX4-art, NOX5, p138 thyroid-oxidase, p138tox, p47phox, p67phox, phagocyte NADPH oxidase, phox, RBOH, RBOHB, RbohF, RDH2, RdxA, renal oxidase, renox, Respiratory Burst Oxidase Homolog, respiratory burst oxidase homologue, rth5, SsNOX38, superoxide-generating NADPH oxidase, ThOX, ThOX2, thyroid NADPH oxidase, thyroid oxidase, thyroid oxidase 2, TK0304, TK0828, TK1186, TK1299, TK1481

ECTree

     1 Oxidoreductases

         1.6 Acting on NADH or NADPH

             1.6.3 With oxygen as acceptor

                1.6.3.1 NAD(P)H oxidase (H2O2-forming)

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104	Activating Compound
3053	AA Sequence
88	Application
1	CAS Registry Number
32	Cloned(Commentary)
105	Cofactor
3	Crystallization (Commentary)
4174	Disease/ Diagnostics
47	Expression
72	General Information
6	General Stability
58	IC50 Value
331	Inhibitors
1	kcat/KM [mM/s]
71	Ki Value [mM]
10	KM Value [mM]
100	Localization
50	Metals/Ions
24	Molecular Weight [Da]
110	Natural Substrates/ Products (Substrates)
627	Organism
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1	pH Range
27	Posttranslational Modification
63	Protein Variants
11	Purification (Commentary)
5	Reaction
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299	Reference
491	Source Tissue
8	Specific Activity [micromol/min/mg]
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183	Substrates and Products (Substrate)
31	Subunits
237	Synonyms
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6	Temperature Stability [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.6.3.1 - NAD(P)H oxidase (H2O2-forming)

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SYSTEMATIC NAME

IUBMB Comments

NAD(P)H:oxygen oxidoreductase (H2O2-forming)

Requires FAD, heme and calcium. When calcium is present, this transmembrane glycoprotein generates H2O2 by transfering electrons from intracellular NAD(P)H to extracellular molecular oxygen. The electron bridge within the enzyme contains one molecule of FAD and probably two heme groups. This flavoprotein is expressed at the apical membrane of thyrocytes, and provides H2O2 for the thyroid peroxidase-catalysed biosynthesis of thyroid hormones.