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1.6.3.2: NAD(P)H oxidase (H2O-forming)

This is an abbreviated version!
For detailed information about NAD(P)H oxidase (H2O-forming), go to the full flat file.

Reaction

2 NADPH +

H+
+
O2
= 2 NADP+ + 2 H2O

Synonyms

KOD1, NAD(P)H oxidase, NOX, NOXtp, TK1299

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.3 With oxygen as acceptor
                1.6.3.2 NAD(P)H oxidase (H2O-forming)

Systematic Name

Systematic Name on EC 1.6.3.2 - NAD(P)H oxidase (H2O-forming)

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SYSTEMATIC NAME
IUBMB Comments
NAD(P)H:oxygen oxidoreductase (H2O-forming)
A flavoprotein (FAD). NADPH is a better substrate than NADH [1,3]. By removal of oxygen the enzyme is involved in aerobic tolerance in the thermophilic anaerobic archaeon Thermococcus profundus and in Giardia intestinalis, a microaerophilic single-celled parasite of the order Diplomonadida.