1.6.5.2: NAD(P)H dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about NAD(P)H dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.6.5.2

Reaction

NAD(P)H
+
H+
+
a quinone
=
NAD(P)+
+
a hydroquinone

Synonyms

1,4-benzoquinone reductase, azoreductase, chromate reductase, ChrR, dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone), diaphorase, DPND, DPNH-diaphorase, DT-diaphorase, DTD, DVU_2399, DVU_2400, DVU_2401, EC 1.6.99.2, FerB, ferric reductase B, flavoprotein NAD(P)H-quinone reductase, FlxABCD, FMN-dependent NAD(P)H:quinone oxidoreductase, Internal NADH dehydrogenase, MdaB, Menadione oxidoreductase, Menadione reductase, NAD(P)H dehydrogenase, NAD(P)H dehydrogenase complex, NAD(P)H menadione reductase, NAD(P)H quinone oxidoreductase, NAD(P)H quinone oxidoreductase-1, NAD(P)H quinone oxidoreductase1, NAD(P)H quinone reductase, NAD(P)H quinone-oxidoreductase 1, NAD(P)H-QR, NAD(P)H-quinone dehydrogenase, NAD(P)H-quinone oxidoreductase, NAD(P)H: (quinone acceptor) oxidoreductase, NAD(P)H: (quinone-acceptor)oxidoreductase, NAD(P)H: menadione oxidoreductase, NAD(P)H: Quinone oxidoreductase, NAD(P)H: quinone oxidoreductase 1, NAD(P)H: quinone oxidoreductase-1, NAD(P)H: quinone reductase, NAD(P)H:acceptor oxidoreductase, NAD(P)H:quinone acceptor oxidoreductase, NAD(P)H:quinone oxidoreducatase 1, NAD(P)H:quinone oxidoreductase, NAD(P)H:quinone oxidoreductase 1, NAD(P)H:quinone oxidoreductase I, NAD(P)H:quinone oxidoreductase-1, NAD(P)H:quinone reductase, NAD(P)H:quinoneoxidoreductase 1, NADH-menadione reductase, NADH:quinone oxidoreductase 1, NADPH quinone reductase, NADPH: quinone oxidoreductase-1, NADPH:quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NAD[P]H:quinone acceptor oxidoreductase 1, Naphthoquinone reductase, Ndh complex, NDH2, nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1, NQO1, NQR, NRH:quinone reductase 1, p-Benzoquinone reductase, Pden_4071, PfNdh2, Phylloquinone reductase, QOR2, QR1, QR2, Quinone reductase, quinone reductase 1, quinone reductase type 1, Reduced NAD(P)H dehydrogenase, reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase, TcpB, TmQR2, type II NADH: quinone oxidoreductase, Viologen accepting pyridine nucleotide oxidoreductase, Vitamin K reductase, vitamin-K reductase, WrbA

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.5 With a quinone or similar compound as acceptor
                1.6.5.2 NAD(P)H dehydrogenase (quinone)

Expression

Expression on EC 1.6.5.2 - NAD(P)H dehydrogenase (quinone)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after 48 h of exposure, 2,3-dehydrosilydianin at concentrations of 25 microM and higher significantly elevates the activity of NQO1 in murine hepatoma Hepa1c1c7 cells. 2,3-dehydrosilydianin causes the accumulation of Nrf2 and significantly induces the expression of the Nqo1 gene at both the mRNA and protein levels
-
basal expression of NQO1 and NADPH cytochrome P450 oxidoreductase is comparable in isolated islets and liver
-
docosahexaenoic acid, DHA, activates transcription factor Nrf2, possibly through modification of a critical Keap1 cysteine288 residue and protein kinase delta-mediated phosphorylation of Nrf2, leading to upregulation of heme oxygenase HO-1 and NQO1 expression
-
expressed in cultures grown under both nitrogen-sufficient and nitrogen-limiting conditions
expression increases during growth in ethanol-sulfate, and to a less extent during pyruvate fermentation
in sub-chronic studies upon oral exposure to sulphoraphane for 30 days a 2- to 3fold increase in GSTM1, Gclc and NQO1 transcript levels, and a 2fold increase in NQO1 activity in adult livers is observed
-
leflunomide elicits significant induction of pulmonary CYP1A1 and NQO1 expression in neonatal mice. The dose at which leflunomide increases NQO1 is significantly higher than that required to induce CYP1A1 enzyme. Leflunomide also enhances hepatic CYP1A1, 1A2 and NQO1 expression in wild-type mice and fails to induce these enzymes in aryl hydrocarbon receptor-null mice
-
NQO1 is inducible
-
NQO1, but not NADPH cytochrome P450 oxidoreductase , is strongly induced in pancreatic beta-cells exposed to menadione
-
palm oil tocotrienol treatment increases NQO1 gene and protein expression in mice liver dose-dependently, with the highest expression seen in mice treated with 1000 mg/kg palm tocotrienol
-
Sudan I induces NQO1 expression in rat liver, kidney, and lung, real-time polymerase chain reaction expression analysis
-
sulforaphane or curcumin significantly increase NQO1 protein expression and activity without triggering G2/M cell cycle arrest or mitotic catastrophe. Sulforaphane and curcumin each increase the NQO1 activity within 24 h, at concentrations as low as 0.1 microM. The minimal quercetin concentration inducing NQO1, is 100fold higher than that which disrupts mitosis. Resveratrol modestly stimulates NQO1, but the minimally effective resveratrol concentration concomitantly induces evidence of cellular apoptosis
-
upon acute treatment with sulforaphane, increased GSTM1, NQO1, HO-1, and Gclc mRNA transcript levels are observed in adult liver, but no change in NQO1 activity
-