1.6.5.2: NAD(P)H dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about NAD(P)H dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.6.5.2

Reaction

NAD(P)H
+
H+
+
a quinone
=
NAD(P)+
+
a hydroquinone

Synonyms

1,4-benzoquinone reductase, azoreductase, chromate reductase, ChrR, dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone), diaphorase, DPND, DPNH-diaphorase, DT-diaphorase, DTD, DVU_2399, DVU_2400, DVU_2401, EC 1.6.99.2, FerB, ferric reductase B, flavoprotein NAD(P)H-quinone reductase, FlxABCD, FMN-dependent NAD(P)H:quinone oxidoreductase, Internal NADH dehydrogenase, MdaB, Menadione oxidoreductase, Menadione reductase, NAD(P)H dehydrogenase, NAD(P)H dehydrogenase complex, NAD(P)H menadione reductase, NAD(P)H quinone oxidoreductase, NAD(P)H quinone oxidoreductase-1, NAD(P)H quinone oxidoreductase1, NAD(P)H quinone reductase, NAD(P)H quinone-oxidoreductase 1, NAD(P)H-QR, NAD(P)H-quinone dehydrogenase, NAD(P)H-quinone oxidoreductase, NAD(P)H: (quinone acceptor) oxidoreductase, NAD(P)H: (quinone-acceptor)oxidoreductase, NAD(P)H: menadione oxidoreductase, NAD(P)H: Quinone oxidoreductase, NAD(P)H: quinone oxidoreductase 1, NAD(P)H: quinone oxidoreductase-1, NAD(P)H: quinone reductase, NAD(P)H:acceptor oxidoreductase, NAD(P)H:quinone acceptor oxidoreductase, NAD(P)H:quinone oxidoreducatase 1, NAD(P)H:quinone oxidoreductase, NAD(P)H:quinone oxidoreductase 1, NAD(P)H:quinone oxidoreductase I, NAD(P)H:quinone oxidoreductase-1, NAD(P)H:quinone reductase, NAD(P)H:quinoneoxidoreductase 1, NADH-menadione reductase, NADH:quinone oxidoreductase 1, NADPH quinone reductase, NADPH: quinone oxidoreductase-1, NADPH:quinone oxidoreductase, NADPH:quinone oxidoreductase 1, NAD[P]H:quinone acceptor oxidoreductase 1, Naphthoquinone reductase, Ndh complex, NDH2, nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1, NQO1, NQR, NRH:quinone reductase 1, p-Benzoquinone reductase, Pden_4071, PfNdh2, Phylloquinone reductase, QOR2, QR1, QR2, Quinone reductase, quinone reductase 1, quinone reductase type 1, Reduced NAD(P)H dehydrogenase, reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase, TcpB, TmQR2, type II NADH: quinone oxidoreductase, Viologen accepting pyridine nucleotide oxidoreductase, Vitamin K reductase, vitamin-K reductase, WrbA

ECTree

     1 Oxidoreductases
         1.6 Acting on NADH or NADPH
             1.6.5 With a quinone or similar compound as acceptor
                1.6.5.2 NAD(P)H dehydrogenase (quinone)

Specific Activity

Specific Activity on EC 1.6.5.2 - NAD(P)H dehydrogenase (quinone)

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000199
-
in total leucocytes
0.0000239
-
in lymphocytes
0.000072
-
in rectal biopsies of the C609T genotype
0.00011
-
in rectal biopsies of the C609C genotype
0.00022
-
48 h after after oral administration of vitamin E
0.00023
-
control, 24 h
0.00024
-
24 h after after oral administration of vitamin E; 48 h after oral administration of manganese; control, 24 h
0.00025
-
48 h after oral administration of cadmium and vitamin E
0.00026
-
48 h after after oral administration of cadmium
0.00055
-
24 h after oral administration of manganese
0.00056
-
24 h after oral administration of cadmium and vitamin E
0.00059
-
24 h after after oral administration of cadmium
0.001
-
below, recombinant enzyme NQO1, substrate 10a, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 10f, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 10g, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 10h, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 10o, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 11d, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 11e, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 11h, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 11i, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 11k, pH not specified in the publication, 37C; below, recombinant enzyme NQO1, substrate 11l, pH not specified in the publication, 37C
0.0014
-
recombinant enzyme NQO1, substrate 10k, pH not specified in the publication, 37C
0.0062
-
recombinant enzyme NQO1, substrate 5-(aziridin-1-yl)-2,4-dinitrobenzamide, i.e. CB-1954, pH not specified in the publication, 37C
0.011
-
recombinant enzyme NQO1, substrate 10c, pH not specified in the publication, 37C
0.013
-
recombinant enzyme NQO1, substrate 2-(3,5-dinitropyridin-2-yl)-1,2,3,4-tetrahydroisoquinoline, pH not specified in the publication, 37C
0.016
-
recombinant enzyme NQO1, substrate 11a, pH not specified in the publication, 37C
0.02
-
recombinant enzyme NQO1, substrate 10n, pH not specified in the publication, 37C
0.038
-
recombinant enzyme NQO1, substrate 10j, pH not specified in the publication, 37C
0.039
-
activity in liver microsomes, reduction of menadione, cofactor NADPH
0.041
-
activity in liver cytosol, reduction of menadione, cofactor NADH
0.042
-
recombinant enzyme NQO1, substrate 10e, pH not specified in the publication, 37C
0.05
-
in lung of control rats
0.051
-
activity in liver cytosol, reduction of menadione, cofactor NADPH
0.053
-
recombinant enzyme NQO1, substrate 10d, pH not specified in the publication, 37C
0.06
-
in lung of rats treated with 0.4 or 4 mg/kg of 3-nitrobenzanthrone
0.076
-
recombinant enzyme NQO1, substrate 10m, pH not specified in the publication, 37C
0.09
-
in kidney of control rats and in lung of rats treated with 40 mg/kg of 3-nitrobenzanthrone
0.11
-
recombinant enzyme NQO1, substrate 10b, pH not specified in the publication, 37C
0.121
-
activity in liver cytosol, reduction of 2,6-dichlorophenolindophenol, cofactor NADPH
0.128
-
activity in liver cytosol, reduction of 2,6-dichlorophenolindophenol, cofactor NADH
0.15
-
in kidney of rats treated with 0.4 or 4 mg/kg of 3-nitrobenzanthrone
0.153
-
activity in liver microsomes, reduction of menadione, cofactor NADH
0.157
-
activity in liver microsomes, reduction of 2,6-dichlorophenolindophenol, cofactor NADPH
0.17
-
recombinant enzyme NQO1, substrate 5,6-dihydro-10-nitropyrido[3'',2'':4',5']imidazo[2',1'-a]isoquinoline 12-oxide, pH not specified in the publication, 37C
0.23
-
in kidney of rats treated with 40 mg/kg of 3-nitrobenzanthrone
0.63
-
activity in liver microsomes, reduction of 2,6-dichlorophenolindophenol, cofactor NADH
3.5
-
with FMN as substrate
4
-
menadione-cytochrome c reduction assay
8.1
-
with ferricyanide and FAD as substrates
35.3
-
with menadione and FAD as substrates
38.1
-
substrate 3-(hydroxymethyl)-5-methoxy-1-methyl-1H-indazole-4,7-dione, pH 7.4, 22C
50
substrate [Fe(CN)6]3-, pH 7.2, 37C
53.9
-
substrate methyl 5-methoxy-4,7-dioxo-4,7-dihydro-1-benzothiophene-2-carboxylate, pH 7.4, 22C
63.8
-
substrate 5-methoxy-4,7-dioxo-4,7-dihydro-1-benzothiophene-2-carboxylic acid, pH 7.4, 22C
80.8
-
substrate 2-(1-hydroxyethyl)-5-methoxy-3-methyl-1-benzofuran-4,7-dione, pH 7.4, 22C
87.9
-
substrate 3-(1-hydroxyethyl)-5-methoxy-2-methyl-1-benzofuran-4,7-dione, pH 7.4, 22C
160
substrate 2,6-dichlorophenolindophenol, pH 7.2, 37C
179.1
-
with ferricyanide and FMN as substrates
217
pH 6.0, temperature not specified in the publication
280
-
pH not specified in the publication, temperature not specified in the publication
430
substrate menadione, pH 7.2, 37C
435.3
-
recombinant enzyme
505
-
isoform III, towards menadione
560
substrate 1,4-naphthoquinone, pH 7.2, 37C
634
-
isoform IV, towards menadione
710
-
cytosol
800
-
purified enzyme
830
-
microsomes
911.4
-
with menadione and FMN as substrates
930
substrate 2,3-dihydroxy-5-methyl-1,4-benzoquinone, pH 7.2, 37C
990
substrate 1,4-benzoquinone, pH 7.2, 37C
1129
-
isoform VII, towards menadione
1186
-
isoform V, towards menadione
1212
-
dichloroindophenol
1300
substrate menadione, pH 7.2, 37C
1400
substrate 2,6-dichlorophenolindophenol, pH 7.2, 37C; substrate [Fe(CN)6]3-, pH 7.2, 37C
1720
-
hydrophilic isoform
1770
-
hydrophobic isoform
2228
-
isoform II, towards menadione
2452
-
2-methyl-1,4-naphthoquinone
2459
-
isoform VIb, towards menadione
2469
-
-
5860
-
isoform VIa, towards menadione
6700
substrate 2,3-dihydroxy-5-methyl-1,4-benzoquinone, pH 7.2, 37C
8900
substrate 1,4-naphthoquinone, pH 7.2, 37C
25000
substrate 1,4-benzoquinone, pH 7.2, 37C
additional information